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Entry version 37 (31 Jul 2019)
Sequence version 1 (28 Nov 2012)
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Protein
Submitted name:

Translation initiation factor 4G

Gene

CNAG_00402

Organism
Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionInitiation factorImported
Biological processProtein biosynthesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Translation initiation factor 4GImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:CNAG_00402Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri235443 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesCryptococcaceaeCryptococcusCryptococcus neoformans species complex
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000010091 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:CNAG_00402

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
J9VLH4

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini899 – 1149MIF4GInterPro annotationAdd BLAST251

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 62DisorderedSequence analysisAdd BLAST62
Regioni127 – 154DisorderedSequence analysisAdd BLAST28
Regioni204 – 233DisorderedSequence analysisAdd BLAST30
Regioni320 – 431DisorderedSequence analysisAdd BLAST112
Regioni462 – 566DisorderedSequence analysisAdd BLAST105
Regioni585 – 646DisorderedSequence analysisAdd BLAST62
Regioni745 – 874DisorderedSequence analysisAdd BLAST130
Regioni1169 – 1337DisorderedSequence analysisAdd BLAST169

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 22PolarSequence analysisAdd BLAST22
Compositional biasi30 – 62PolarSequence analysisAdd BLAST33
Compositional biasi140 – 154PolarSequence analysisAdd BLAST15
Compositional biasi332 – 371PolarSequence analysisAdd BLAST40
Compositional biasi372 – 396Pro-richSequence analysisAdd BLAST25
Compositional biasi397 – 412PolarSequence analysisAdd BLAST16
Compositional biasi483 – 566PolyampholyteSequence analysisAdd BLAST84
Compositional biasi585 – 624PolyampholyteSequence analysisAdd BLAST40
Compositional biasi767 – 797PolarSequence analysisAdd BLAST31
Compositional biasi811 – 874PolarSequence analysisAdd BLAST64
Compositional biasi1202 – 1279PolarSequence analysisAdd BLAST78
Compositional biasi1305 – 1337PolyampholyteSequence analysisAdd BLAST33

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.970.30, 1 hit
1.25.40.180, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR022745 eIF4G1_eIF4E-bd
IPR036211 eIF4G_eIF4E-bd_sf
IPR016021 MIF4-like_sf
IPR003890 MIF4G-like_typ-3

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12152 eIF_4G1, 1 hit
PF02854 MIF4G, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00543 MIF4G, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF101489 SSF101489, 1 hit
SSF48371 SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

J9VLH4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSQNTNPTVN GDNKTSASGS IASVWARGPP SAVSSASASK NQSGANTPSQ
60 70 80 90 100
DGAGLSNLTS ASNSTAISIR NAHSRQNSLL VGPGGVDIKK GNIAFGTVDS
110 120 130 140 150
PNTALSSSPA APSTTGGHLA DAVKSFGSID ADGNSDPDVV KTRRTSSLSN
160 170 180 190 200
PIGPVQEKKL SVHSLFTSKA PAQVPLGSSP SRPAMSPPQL HQQPIPHIRR
210 220 230 240 250
QSMGQGGPGF QGQMPVGSPS FTSGPPMRPP IVMPNQPRSP VANPNIPHGQ
260 270 280 290 300
YSPMPPLHVQ QGFRPPQQGM GAQQPPVRPN GMGTQGMPRP MMGPGQYGMH
310 320 330 340 350
PGPQAPQYPV MGYPPQGGFY PGYGPYDQQP HYGSPQWASQ QQNQSFNGNF
360 370 380 390 400
GPGPMSPRTG PSQISSAPSQ SPLPPQGVPL GSGGPSPIPT PPSRPPNLMT
410 420 430 440 450
GHQHSASIPT TPVPSTPSRP MQANVPPPFL SGAASVFTPR GASKAVKIAR
460 470 480 490 500
EDGTAVNMKE VAEAASKAVS SGAHTPESAA QQSKDDAPRR KPGLPVIVRL
510 520 530 540 550
ESEEQKKKRV AEEEREAKLK SVEEKEEQER RERLEKKIKE DEERRAKEAA
560 570 580 590 600
EKAEAEKNAK EEEEKKKLDE AYAAEALAAK KLTEEKEATA KAAKEKTEAA
610 620 630 640 650
EREKLAAHAA TQEAREKAEE QRRELLSTPV TPVAVSPAGS PALGAGLPAK
660 670 680 690 700
PVAAISGAKR TLPAAPELAS TSVATVNETP SASASALSSA RPINDLSSIT
710 720 730 740 750
YPATLKSPDP RLNVDAEPGK FRYDREFLMQ FMAVCREKPD TLPPLEDIGL
760 770 780 790 800
EVDGGSGFGG RSSRGGSRAS MGPSNRSATG GAGLGISGSN RSAFPGQGMG
810 820 830 840 850
QFGSMGQFGS GAGPIRSTSE QRYRASLSNR TPSSLSGLPS LGISGSRTGA
860 870 880 890 900
NRGSQRGSKR APQSSQVQTS AATPIPISEN AWTRTRLGGD AQGTPAYIER
910 920 930 940 950
KVKALLNKLT EEKFDPISLQ ILEWANKSAN ETDGLTLKLV IKLIFEKATD
960 970 980 990 1000
EAHWSAMYAK LCKLLHDEIS PEVSDTIDGK PVAGRALFRR YLLGRCQVDF
1010 1020 1030 1040 1050
EAGWKAREDT AVAAAAKKEE DGAKQEEAKD DKDKEAVLMS DEYYAAQKAK
1060 1070 1080 1090 1100
RRGLGLVQLI GELFKREMIS NRVIKECLLK LLSNTTDPDE EDIESACKLL
1110 1120 1130 1140 1150
TTIGAAYDRV APENLSKAFD MLSKMMQVES LSSRIKFMIM DVFDLRKHGW
1160 1170 1180 1190 1200
KSKKNQTSVM TIAQIHEQNA KEKSAAATAV SKESISRGGS RSGRDRHEGS
1210 1220 1230 1240 1250
QPGEWQSVSA GPRSLNRPTD FSNMGRNISS GGTAPSFGPT SIFNTRKGKA
1260 1270 1280 1290 1300
GTPTNVTPPM SRQPSSANMF SALNDTQEND PVSAERRTST DNGESAPQRK
1310 1320 1330 1340 1350
RLNLAPRTKP IEGEGENKDE GADEELHGDR VDDHELSEEE AKAKIDLDMK
1360 1370 1380 1390 1400
ELWGEKDQGG SRNPEDIADY FSALPVSRRP LLAERLLNDI FRISRLKDAE
1410 1420 1430 1440 1450
VVAKGWKTAL LQQSVSADVL RQSLEHRMPT LDDESIDFPS AYEAVALLVR
1460 1470 1480 1490
NVSLSQEDIN AMVGRIEVEG TPRITPPQKM EKALRKVDEA GSLA
Length:1,494
Mass (Da):159,592
Last modified:November 28, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7285044974D8BA37
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP003820 Genomic DNA Translation: AFR92535.1

NCBI Reference Sequences

More...
RefSeqi
XP_012046695.1, XM_012191305.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
AFR92535; AFR92535; CNAG_00402

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
23884210

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003820 Genomic DNA Translation: AFR92535.1
RefSeqiXP_012046695.1, XM_012191305.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

PTM databases

SwissPalmiJ9VLH4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiAFR92535; AFR92535; CNAG_00402
GeneIDi23884210

Organism-specific databases

EuPathDBiFungiDB:CNAG_00402

Family and domain databases

Gene3Di1.20.970.30, 1 hit
1.25.40.180, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR022745 eIF4G1_eIF4E-bd
IPR036211 eIF4G_eIF4E-bd_sf
IPR016021 MIF4-like_sf
IPR003890 MIF4G-like_typ-3
PfamiView protein in Pfam
PF12152 eIF_4G1, 1 hit
PF02854 MIF4G, 1 hit
SMARTiView protein in SMART
SM00543 MIF4G, 1 hit
SUPFAMiSSF101489 SSF101489, 1 hit
SSF48371 SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiJ9VLH4_CRYNH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: J9VLH4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 28, 2012
Last sequence update: November 28, 2012
Last modified: July 31, 2019
This is version 37 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
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Main funding by: National Institutes of Health

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