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Entry version 46 (29 Sep 2021)
Sequence version 1 (28 Nov 2012)
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Protein

Mevalonate kinase

Gene

CNAG_02686

Organism
Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinaseARBA annotation, LyaseImported, Transferase
Biological processLipid biosynthesisARBA annotation, Lipid metabolism
LigandATP-bindingARBA annotation, Nucleotide-binding, Pyridoxal phosphateARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mevalonate kinaseARBA annotation (EC:2.7.1.36ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:CNAG_02686Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri235443 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesCryptococcaceaeCryptococcusCryptococcus neoformans species complex
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000010091 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:CNAG_02686

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
J9VKQ5

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini612 – 687GHMP_kinases_NInterPro annotationAdd BLAST76

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GHMP kinase family. Mevalonate kinase subfamily.ARBA annotation

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_009484_0_1_1

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00614, CGS_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.230.10, 1 hit
3.30.70.890, 1 hit
3.40.640.10, 1 hit
3.90.1150.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000277, Cys/Met-Metab_PyrdxlP-dep_enz
IPR006238, Cys_b_lyase_euk
IPR036554, GHMP_kinase_C_sf
IPR006204, GHMP_kinase_N_dom
IPR006203, GHMP_knse_ATP-bd_CS
IPR006205, Mev_gal_kin
IPR015424, PyrdxlP-dep_Trfase
IPR015421, PyrdxlP-dep_Trfase_major
IPR015422, PyrdxlP-dep_Trfase_small
IPR020568, Ribosomal_S5_D2-typ_fold
IPR014721, Ribosomal_S5_D2-typ_fold_subgr

The PANTHER Classification System

More...
PANTHERi
PTHR11808, PTHR11808, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01053, Cys_Met_Meta_PP, 1 hit
PF00288, GHMP_kinases_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53383, SSF53383, 1 hit
SSF54211, SSF54211, 1 hit
SSF55060, SSF55060, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01329, cysta_beta_ly_E, 1 hit
TIGR00549, mevalon_kin, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00868, CYS_MET_METAB_PP, 1 hit
PS00627, GHMP_KINASES_ATP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

J9VKQ5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTPSTPGES SLATSVYSLA PKSPVEVHKE RVANWRFSTI CANVDGKDQY
60 70 80 90 100
GASSTPIYQT ATFKGMDGQY DYTRSGNPTR GALENHLARL YGATQTFALS
110 120 130 140 150
TGMTCLDTIL RLVRPGETVL AGDDLYGGTN RLLTYLGTHG GVDVRHVDTT
160 170 180 190 200
DVDKVIPHLG PGNNVKMVLL ESPTNPLLKI ADLQAIADAV HSAAPNALIV
210 220 230 240 250
VDNTMMSPYL QRPLEIGADI VYDSATKYLS GHHDLMAGII AASRPDICKD
260 270 280 290 300
IAFIINSVGS GLAPFDSFLL LRGVKTMSLR MDRQMATAQL VALYLDSFGF
310 320 330 340 350
LVHYPGLKSH PKRDIHYKQA SGAGAVLSFV TGDKALSERI VGGTRLWGIS
360 370 380 390 400
VSFGAVNSLI SMPCLMSHAS ISAAVRAERG LPENLIRLCV GIEDPRDLVD
410 420 430 440 450
DLEHSLLQAG AIVPNLQYTP LSQAEAAELY AKDGEAWILE RAKGFKRPST
460 470 480 490 500
ESITVDKLVS SVKQSLGFST PSKEYKTIDE DIAVSAPGKV ILFGEHAVVH
510 520 530 540 550
GVTAVASSVD LRCFSVLSPR RDGKIGLEVP NIGVELEWEI SKLPWNLLPV
560 570 580 590 600
HANGDRHVAD QELDTALLQA VEGAVNTHVE VGKTGIGACV AFLYLYMMIS
610 620 630 640 650
GEETNALSVT FTASSNLPIS AGLGSSAAYS TCVAASFLLA RQHLTIPSAD
660 670 680 690 700
RLPKEDTDLV DGWAFLAEKV LHGNPSGIDN AVSVRGGAVA FTRSVGGKQG
710 720 730 740 750
GMDGLFGFSS VRLLLTNTLI PRDTKTLVAG VSAKRLAEPQ AVNSILDSIQ
760 770 780 790 800
AISDEARSLL GGGKPVERFI LVKRLEALIK ENHEYLVKLG VSHPSLEMIV
810 820 830 840 850
AATAQAPFEL ATKLTGAGGG GCALTLIPDA FPESSLNELI QTLEGHGFQP
860 870 880 890 900
HLTTLGGPGL GVLTIPSKLG QASDQLRDAV RTHDEGEGMV VPKRAGLREA
910
DKEGLHAWAE RLGRWVYA
Length:918
Mass (Da):97,825
Last modified:November 28, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF7BE28B7B3BF606A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
CP003822 Genomic DNA Translation: AFR94006.1

NCBI Reference Sequences

More...
RefSeqi
XP_012048067.1, XM_012192677.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
AFR94006; AFR94006; CNAG_02686

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
23886249

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003822 Genomic DNA Translation: AFR94006.1
RefSeqiXP_012048067.1, XM_012192677.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

PTM databases

SwissPalmiJ9VKQ5

Genome annotation databases

EnsemblFungiiAFR94006; AFR94006; CNAG_02686
GeneIDi23886249

Organism-specific databases

VEuPathDBiFungiDB:CNAG_02686

Phylogenomic databases

HOGENOMiCLU_009484_0_1_1

Family and domain databases

CDDicd00614, CGS_like, 1 hit
Gene3Di3.30.230.10, 1 hit
3.30.70.890, 1 hit
3.40.640.10, 1 hit
3.90.1150.10, 1 hit
InterProiView protein in InterPro
IPR000277, Cys/Met-Metab_PyrdxlP-dep_enz
IPR006238, Cys_b_lyase_euk
IPR036554, GHMP_kinase_C_sf
IPR006204, GHMP_kinase_N_dom
IPR006203, GHMP_knse_ATP-bd_CS
IPR006205, Mev_gal_kin
IPR015424, PyrdxlP-dep_Trfase
IPR015421, PyrdxlP-dep_Trfase_major
IPR015422, PyrdxlP-dep_Trfase_small
IPR020568, Ribosomal_S5_D2-typ_fold
IPR014721, Ribosomal_S5_D2-typ_fold_subgr
PANTHERiPTHR11808, PTHR11808, 1 hit
PfamiView protein in Pfam
PF01053, Cys_Met_Meta_PP, 1 hit
PF00288, GHMP_kinases_N, 1 hit
SUPFAMiSSF53383, SSF53383, 1 hit
SSF54211, SSF54211, 1 hit
SSF55060, SSF55060, 1 hit
TIGRFAMsiTIGR01329, cysta_beta_ly_E, 1 hit
TIGR00549, mevalon_kin, 1 hit
PROSITEiView protein in PROSITE
PS00868, CYS_MET_METAB_PP, 1 hit
PS00627, GHMP_KINASES_ATP, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiJ9VKQ5_CRYNH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: J9VKQ5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 28, 2012
Last sequence update: November 28, 2012
Last modified: September 29, 2021
This is version 46 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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