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Entry version 44 (29 Sep 2021)
Sequence version 2 (13 Nov 2013)
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Protein
Submitted name:

Paired amphipathic helix protein Sin3a

Gene

CNAG_02981

Organism
Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Paired amphipathic helix protein Sin3aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:CNAG_02981Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri235443 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesCryptococcaceaeCryptococcusCryptococcus neoformans species complex
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000010091 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:CNAG_02981

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

NucleusPROSITE-ProRule annotationARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
J9VJV1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini485 – 587HDAC_interactInterPro annotationAdd BLAST103

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni78 – 210DisorderedSequence analysisAdd BLAST133
Regioni305 – 356DisorderedSequence analysisAdd BLAST52
Regioni776 – 889DisorderedSequence analysisAdd BLAST114
Regioni1237 – 1332DisorderedSequence analysisAdd BLAST96

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi101 – 117Polar residuesSequence analysisAdd BLAST17
Compositional biasi120 – 134Pro residuesSequence analysisAdd BLAST15
Compositional biasi162 – 181Pro residuesSequence analysisAdd BLAST20
Compositional biasi311 – 328Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi789 – 805Acidic residuesSequence analysisAdd BLAST17
Compositional biasi821 – 841Basic and acidic residuesSequence analysisAdd BLAST21
Compositional biasi845 – 873Polar residuesSequence analysisAdd BLAST29
Compositional biasi1269 – 1285Pro residuesSequence analysisAdd BLAST17

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001360_2_2_1

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1160.11, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013194, HDAC_interact_dom
IPR003822, PAH
IPR036600, PAH_sf
IPR039774, Sin3-like
IPR031693, Sin3_C

The PANTHER Classification System

More...
PANTHERi
PTHR12346, PTHR12346, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02671, PAH, 2 hits
PF08295, Sin3_corepress, 1 hit
PF16879, Sin3a_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00761, HDAC_interact, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47762, SSF47762, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51477, PAH, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

J9VJV1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKEFKGQVID TPGVIDRVST LFRGHPSLIQ GFNTFLPPGY RIECFGGEGD
60 70 80 90 100
ASGLITVTTP AGTVSQIPGN FAAAIDQRER EAREGIQASA AEATARDSRA
110 120 130 140 150
GSSAPYPSAT SQGGAPAQPL PPLNALPSHI PSGPPPFQGT SHTGRQATAP
160 170 180 190 200
PPARQAPANQ GPGTLPLPPH AQHPLPPSGP STPSAAQFLA SGGLSHGAQP
210 220 230 240 250
APQPQQGGNR APILEFNHAI TFVNKIKTRF NNDPETYKQF LEILQTYQRD
260 270 280 290 300
TRDIAEVYEQ VTKLFTNAPD LLDEFKQFLP ENGTGGLGML SGSFMQAAGA
310 320 330 340 350
APAVPEKVAG QKRGVAKEGK EMGQKKRRTA ASGVEPATKA TQGKRARAGQ
360 370 380 390 400
RESPIEDVEP GLSVLTPQQQ TLASPDEVAF FDKVKKFIDD KVVYHEFLKL
410 420 430 440 450
INLFVQDMID TKTLLDRAQL FIGDAPEVWA TFQRVVGVDS EGRIPPNPAS
460 470 480 490 500
IQGGYGFGGM IGIDNLMVEN TPMLDRVKPD MNLASANQVG PSYRQLPRSE
510 520 530 540 550
INLQCTGRDA MCWEVLNDEW VAHPTWNAED VAPFVSHRKN QFEDNLHKSE
560 570 580 590 600
EERHEYDYHI EANLRTIALL EPLNNKIQTM EPEERANFNL KAGLGGQSKS
610 620 630 640 650
IYQRIIKKVY GKELGPDVIR ALHDNPVVAL PIVLERLKAK DEEWKRAQRE
660 670 680 690 700
WNRLWREQDA KNFYKALDYQ HSGTKATDKK KVAPAKTLIN EIEARKAEQL
710 720 730 740 750
NQRSALVDFR VWRAKPQMEF EFTDMDVLKD SMKLIISYLD RMQSNSLSSA
760 770 780 790 800
DQVKVEHFLR DFVPILFMLD KDEFDAEFGD GGEPNKTPEE ESEDSDGDEE
810 820 830 840 850
SGSVADDAEV SSNAGGGSAR GGKGEKRHAA DLRKRLLKQA AGDNVSRELS
860 870 880 890 900
VTTTGPTEDG QLQPSTEPLS GEVTPLTENG ERADTPLPVP ADPEEVAEAV
910 920 930 940 950
EKDKAGAEAS EQTWVKIDGV ATESQPLSGR SSVNGEKEKE QSVKAKRKGN
960 970 980 990 1000
FFANSHFYVL SRYIQMLYSR LMTCKTIASK LANENRRPVN PLALKLGLVD
1010 1020 1030 1040 1050
PVTQYFGILQ GDNPAEHYYS HLLSLLERYF DNEIEFGAFE DALRLMFTNE
1060 1070 1080 1090 1100
AYLMFNLDKV IGGIVRQIQT IVGDLKSQEL FALLQRDRAN ARTSTKNQIA
1110 1120 1130 1140 1150
YRMQAEGVLG GNENLYKIEW LPGKETLTIQ LLSEDDRSVD DAETTQERWA
1160 1170 1180 1190 1200
QYIESFALTH PTEGLLKRVD SPFLRRNITK IHSREEELSA SAGPSSSAKN
1210 1220 1230 1240 1250
NVEAKDGLEI KIALGNYRMF FTPGTEDYFH RAYKHEERVK PRSRKAVDAP
1260 1270 1280 1290 1300
APAPESAPAS APESAPASAP ESAPAPAPAP APAPAPAAEV QENGGESADA
1310 1320 1330
GAGAGADANT NADAGVESST VVPEPPVATT AE
Length:1,332
Mass (Da):145,653
Last modified:November 13, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBC0D1A1BC61E0141
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP003822 Genomic DNA Translation: AFR93711.2

NCBI Reference Sequences

More...
RefSeqi
XP_012047820.1, XM_012192430.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
AFR93711; AFR93711; CNAG_02981

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
23886522

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003822 Genomic DNA Translation: AFR93711.2
RefSeqiXP_012047820.1, XM_012192430.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

PTM databases

SwissPalmiJ9VJV1

Genome annotation databases

EnsemblFungiiAFR93711; AFR93711; CNAG_02981
GeneIDi23886522

Organism-specific databases

VEuPathDBiFungiDB:CNAG_02981

Phylogenomic databases

HOGENOMiCLU_001360_2_2_1

Family and domain databases

Gene3Di1.20.1160.11, 3 hits
InterProiView protein in InterPro
IPR013194, HDAC_interact_dom
IPR003822, PAH
IPR036600, PAH_sf
IPR039774, Sin3-like
IPR031693, Sin3_C
PANTHERiPTHR12346, PTHR12346, 1 hit
PfamiView protein in Pfam
PF02671, PAH, 2 hits
PF08295, Sin3_corepress, 1 hit
PF16879, Sin3a_C, 1 hit
SMARTiView protein in SMART
SM00761, HDAC_interact, 1 hit
SUPFAMiSSF47762, SSF47762, 3 hits
PROSITEiView protein in PROSITE
PS51477, PAH, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiJ9VJV1_CRYNH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: J9VJV1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 28, 2012
Last sequence update: November 13, 2013
Last modified: September 29, 2021
This is version 44 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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