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Entry version 43 (02 Jun 2021)
Sequence version 1 (28 Nov 2012)
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Protein
Submitted name:

Translation initiation factor 4G

Gene

CNAG_00386

Organism
Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionInitiation factorImported
Biological processProtein biosynthesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Translation initiation factor 4GImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:CNAG_00386Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri235443 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesCryptococcaceaeCryptococcusCryptococcus neoformans species complex
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000010091 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:CNAG_00386

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
J9VIW2

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini579 – 832MIF4GInterPro annotationAdd BLAST254

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 318DisorderedSequence analysisAdd BLAST318
Regioni426 – 570DisorderedSequence analysisAdd BLAST145
Regioni696 – 717DisorderedSequence analysisAdd BLAST22
Regioni853 – 1015DisorderedSequence analysisAdd BLAST163

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 45Pro residuesSequence analysisAdd BLAST45
Compositional biasi56 – 86Polar residuesSequence analysisAdd BLAST31
Compositional biasi121 – 162Polar residuesSequence analysisAdd BLAST42
Compositional biasi193 – 218Polar residuesSequence analysisAdd BLAST26
Compositional biasi236 – 296Basic and acidic residuesSequence analysisAdd BLAST61
Compositional biasi446 – 463Polar residuesSequence analysisAdd BLAST18
Compositional biasi471 – 511Polar residuesSequence analysisAdd BLAST41
Compositional biasi518 – 553Polar residuesSequence analysisAdd BLAST36
Compositional biasi869 – 949Polar residuesSequence analysisAdd BLAST81
Compositional biasi957 – 977Basic and acidic residuesSequence analysisAdd BLAST21
Compositional biasi996 – 1012Acidic residuesSequence analysisAdd BLAST17

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002459_2_1_1

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.970.30, 1 hit
1.25.40.180, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024, ARM-type_fold
IPR022745, eIF4G1_eIF4E-bd
IPR036211, eIF4G_eIF4E-bd_sf
IPR016021, MIF4-like_sf
IPR003890, MIF4G-like_typ-3

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12152, eIF_4G1, 1 hit
PF02854, MIF4G, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00543, MIF4G, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF101489, SSF101489, 1 hit
SSF48371, SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

J9VIW2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPPQPAPARQ NGVPQQPIPR PPVPQQGIPA HFPVPNQPPA QYPVMAYPPQ
60 70 80 90 100
SGFYPGYNPY EQQQNFGMPP QWAPQHHPQN QFPGGYNARP VSPPSGTAPF
110 120 130 140 150
QPAQQPFIHN SPFPGGSGPN APQTPLRSSG PALNGHQHTS SNASQASTPS
160 170 180 190 200
TPNFSLSGAS AAFTPRRSAA IKISRPDGTE LDLKKEVLKV SSATASPAPT
210 220 230 240 250
SPASTPHTPA TPNSELKNVK VDTPKKPVFG LPVTVKIERP EERAARLEEE
260 270 280 290 300
AKRERIRAQE EKEEKERKER LEKKAKEEEE KKAKDVAEKT EQADSASEPI
310 320 330 340 350
KAEVNGSVEE VISGAPSSVP SPALGAGLPP KPVSVVNGTN ALPTALNLAS
360 370 380 390 400
ASASVVSEPS SASISALSSA RPIEDIHAIS YPGSLKSPNP QLNVSAEPRK
410 420 430 440 450
FRYDREFLMQ FMNICKEKPE SLPPLEEIGL EADGGSGFGS RGPRGGRSSQ
460 470 480 490 500
GPSSRTGSTG LGIGGVNRAT MGSFSMGQFG SGSGSLRNST SEQRYRASLS
510 520 530 540 550
GRSSSQGGPG GLPSLSGLPS MGLSSSRSGE SRGSQRGSKR VPQSSQPSTP
560 570 580 590 600
AAAPIPISEN AWTRKRLGGD AEGTPAYIER KVKALLNKLT EEMFDPISKQ
610 620 630 640 650
ILEWANKSAN ETDGLTLKLV IKLIFEKATD EAHWSSMYAK LCRLLHDEIS
660 670 680 690 700
NDVSDTIDGQ VISGRSLFRR YLLGRCQVDF EAGWKAREDT AVAAAAKKDE
710 720 730 740 750
DEAKQEKAKA EDSGEEKEAD LMSDEYYAAQ KAKRRGLGLI QLIGELFKRE
760 770 780 790 800
IVANRVISQC LLKLLSNVND PDEEDIESAC KLLTTVGAAY DRAARENLNK
810 820 830 840 850
AFDVLNQMMK IDSLPSRIKF MIMDLNDLRR EGWKSRKNQS GVMTIAEIHE
860 870 880 890 900
QNAKEKNAAA AAARESLSRG GSRSGNRRDG TQPGEWQSVS SNPRSISRPT
910 920 930 940 950
DFSNIGRNIS SSSVTPSFGP SSVFANRKGK PATASNAPSP TSRPSSANMF
960 970 980 990 1000
SALHEAHESE SPAERRTSTD DGEAAPQRKK LNLAPRTKPL AAEDDSREEG
1010 1020 1030 1040 1050
EEAQFEEEAA GTELSEGDIK SKIDLDMKEL WGDKDQGGSR NPADVAEYFS
1060 1070 1080 1090 1100
SLPESRRSLL ATRLLDDLFR ISKLKDAEVV AKGWKVSLEQ QAVSSEVLKQ
1110 1120 1130 1140 1150
ALEARMPTLD DEAIDFPNAY DAVALLTRSL SLSDDDVSAL GDKIEVDGTP
1160
RITPKQKLEK ALAKLNEQA
Length:1,169
Mass (Da):125,951
Last modified:November 28, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i04B35B754CA5B513
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP003820 Genomic DNA Translation: AFR92519.1

NCBI Reference Sequences

More...
RefSeqi
XP_012046685.1, XM_012191295.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
AFR92519; AFR92519; CNAG_00386

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
23884194

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003820 Genomic DNA Translation: AFR92519.1
RefSeqiXP_012046685.1, XM_012191295.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

PTM databases

SwissPalmiJ9VIW2

Genome annotation databases

EnsemblFungiiAFR92519; AFR92519; CNAG_00386
GeneIDi23884194

Organism-specific databases

VEuPathDBiFungiDB:CNAG_00386

Phylogenomic databases

HOGENOMiCLU_002459_2_1_1

Family and domain databases

Gene3Di1.20.970.30, 1 hit
1.25.40.180, 1 hit
InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR022745, eIF4G1_eIF4E-bd
IPR036211, eIF4G_eIF4E-bd_sf
IPR016021, MIF4-like_sf
IPR003890, MIF4G-like_typ-3
PfamiView protein in Pfam
PF12152, eIF_4G1, 1 hit
PF02854, MIF4G, 1 hit
SMARTiView protein in SMART
SM00543, MIF4G, 1 hit
SUPFAMiSSF101489, SSF101489, 1 hit
SSF48371, SSF48371, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiJ9VIW2_CRYNH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: J9VIW2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 28, 2012
Last sequence update: November 28, 2012
Last modified: June 2, 2021
This is version 43 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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