Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 34 (31 Jul 2019)
Sequence version 1 (28 Nov 2012)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein
Submitted name:

THO complex subunit 2

Gene

CNAG_03942

Organism
Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
THO complex subunit 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:CNAG_03942Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri235443 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaTremellomycetesTremellalesCryptococcaceaeCryptococcusCryptococcus neoformans species complex
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000010091 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:CNAG_03942

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
J9VGE0

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini36 – 704THOC2_NInterPro annotationAdd BLAST669
Domaini719 – 794Thoc2InterPro annotationAdd BLAST76
Domaini1112 – 1429Tho2InterPro annotationAdd BLAST318

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 23DisorderedSequence analysisAdd BLAST23
Regioni124 – 143DisorderedSequence analysisAdd BLAST20
Regioni298 – 318DisorderedSequence analysisAdd BLAST21
Regioni1021 – 1056DisorderedSequence analysisAdd BLAST36
Regioni1457 – 2066DisorderedSequence analysisAdd BLAST610

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1164 – 1184Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi7 – 23PolarSequence analysisAdd BLAST17
Compositional biasi125 – 143PolyampholyteSequence analysisAdd BLAST19
Compositional biasi1036 – 1053PolarSequence analysisAdd BLAST18
Compositional biasi1467 – 1496PolarSequence analysisAdd BLAST30
Compositional biasi1549 – 1591PolarSequence analysisAdd BLAST43
Compositional biasi1625 – 1639PolarSequence analysisAdd BLAST15
Compositional biasi1670 – 1686PolarSequence analysisAdd BLAST17
Compositional biasi1687 – 1747PolyampholyteSequence analysisAdd BLAST61
Compositional biasi1756 – 1895PolyampholyteSequence analysisAdd BLAST140
Compositional biasi1903 – 1919PolarSequence analysisAdd BLAST17
Compositional biasi1937 – 1956PolarSequence analysisAdd BLAST20
Compositional biasi1977 – 2050PolyampholyteSequence analysisAdd BLAST74

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR040007 Tho2
IPR021418 THO_THOC2_C
IPR021726 THO_THOC2_N
IPR032302 THOC2_N

The PANTHER Classification System

More...
PANTHERi
PTHR21597 PTHR21597, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11262 Tho2, 1 hit
PF11732 Thoc2, 1 hit
PF16134 THOC2_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

J9VGE0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPPRRSTAKS KVQSATTSSL SPAEVITPSL NEQLSEFISQ WETTGTESLH
60 70 80 90 100
GLIISLLNTI ASAPTTLGVV PLLHVLVTLL KSNVDERELT GVFEGVLDEL
110 120 130 140 150
EDERRDIFGE ALVDAVEVLE EEQEDMGENK IKEEKEAKEA EDKSPKGVSI
160 170 180 190 200
LKLLLESNTL PSYIPNLLLN PERLIPLNLH PMPRNPRALQ SALVKKNTTL
210 220 230 240 250
FFKQRKFNLL RECSEGFSGL IVLLTSEDSL PSHPEEEDDE ERRDRAERVW
260 270 280 290 300
GKIMRLVGYF NLSPPRVLDI ILEVFSCHIT HHWPFFLELL RCSPWGPNSS
310 320 330 340 350
QDDGDGESST EKGWKEEEVE GIENALKRDG DRVLCQVLGF KFGFFRKSEA
360 370 380 390 400
GDTPIYLIYT AALLVKHGFV SLTDLLPCLS PDDNEMETVR KKWASSLSSR
410 420 430 440 450
SGPANALTNT ILDDDEPPSG VIGSITEQAQ NIPTKPPPEQ RIQLTQALLA
460 470 480 490 500
LGDKAASEYM LARWPWIAQK STGVADLILD IVEDAIKPVY EEVVANREED
510 520 530 540 550
EKFDLQAAAP IVQESESTEK QAVLTLFAPT PPETRTKKFK FFYPHRGGVC
560 570 580 590 600
ESWSSVEEIH EKGLRWLGLI GGLGGRRARL MVMLSRIGAA HFERLRKNKL
610 620 630 640 650
EQGLAVEHLQ PTEEELKPWL DIIRISLLPS LSCSTASGTF DVELWSLLKL
660 670 680 690 700
FPYTSRYSLY GEWRDSTCNA NGKKPCLMAA HAAAMTTKEV QKALRRVTST
710 720 730 740 750
NTSATSGATP TERHSARALA KQSHHNPVFV WTTAVTQVKA YPNIGEAIVD
760 770 780 790 800
AGRYMAQLSF DVATFVMLDT LSDDRALRLN EMGTGVALWL ERLSKFVGDF
810 820 830 840 850
NRRYSNMDLY PVLQYIINRL MRGHSGDLII LEKLMSSMSG IEPVPNDGVS
860 870 880 890 900
EAQLHAYAGG REMIREAFSA TRISVTAPPE PGASEQPARA PVEKVKNVKK
910 920 930 940 950
SLPRLVNALR EKGLAMPIWI ALAQTRQAVV DKMVNAPIKA MNLVQDTCHN
960 970 980 990 1000
TFVQFGDFLV DYLTSDEHIA LTPDLQQLVV DFGLEYGMAF QILRPRLNAE
1010 1020 1030 1040 1050
IERARVEEKA AVQARLEAAK KAMSEKERTG SPQKVESPAF PGSPTTPSLQ
1060 1070 1080 1090 1100
ITPGATPGPG EIEDVVMEEI EKGALSVPAP KTLSSKGKMW WPSALTATMQ
1110 1120 1130 1140 1150
QTRKLLPREA NEVMSAPFFV IFWHLTTPDI AFSPQSYDNA IKSINRHIST
1160 1170 1180 1190 1200
ISSWRVNPRD KPKMAEQRDE LARLKARVKV LQEEKETHGS LVNGPMKRRM
1210 1220 1230 1240 1250
RLESGKWFGK AIVEKNLQRP LAIQLHQYCF YPRAILSPCD AVFVAKFIRM
1260 1270 1280 1290 1300
AHDLGTAGFS TLFVYNNFFN DNLAACIFSC TDSEARNLGR CLALILADLD
1310 1320 1330 1340 1350
KWHQSENVYL KEALGISPNP IEGGEQKRLP GMLFRSKAGD DMREMSWQEF
1360 1370 1380 1390 1400
RNFYAKCHNV LTRALISCWS EAEFMHNKNA IIVALQVIKY FPLMETNGKA
1410 1420 1430 1440 1450
VEAAVKKLQA GEVGEIPNDL KMMCTSFLSG LKKRQGARPF VAPATFHGAA
1460 1470 1480 1490 1500
ARAAITRAPS APKVESPAPS GTISTPSRPQ PTNGVNGTAS PSPAGTPGPM
1510 1520 1530 1540 1550
TTDPRTLRQK VEESRARAAA SAAAKEQEAG AAPQSPLVHP IPTRPGVPTR
1560 1570 1580 1590 1600
LASSANSVPV TPTGPSAITR TSTPNATSVN SRAQTPVSSM GPPLDISVDE
1610 1620 1630 1640 1650
ARAAARARRL GGIHRPPPPP PSAAAQTTHT AVSTPSTNLD VERQEEKAGE
1660 1670 1680 1690 1700
EGKEPGTPPI PVAESTRGRS PPASVKTSPT TTVRTHRDGS VESRASERSK
1710 1720 1730 1740 1750
RREQDRDKTR RDRDHRDRDK EREREKERDR RDRSAAEDDK RRQEDNAPAS
1760 1770 1780 1790 1800
TQSDAGRESR RSRRDGERER DREEKKNRER ERDDRKERDR DRSHRGEDSD
1810 1820 1830 1840 1850
RKRKRDEESS SRKLEPDASS GSRKERERER RRYDERDRER ERDFRDRDRD
1860 1870 1880 1890 1900
RERDRNERDR DGHRDRRERE RDGRRRDREG RDIRENRERH RTPPAEDGSG
1910 1920 1930 1940 1950
LASAASKDST DTASNASGHG PARTPHALPA RPGNSEQAPR LPQNAAPVSQ
1960 1970 1980 1990 2000
NPQEPLSLAA RMGGIARPAS PHVRANEPVH RSTRDDLRRD NGWNNAPRRD
2010 2020 2030 2040 2050
EATKEESRKE PADRKRALEA ETGSEAREES PGASKRVKID RNKARGRRQE
2060
GGVKMFQQAM GSAKDK
Length:2,066
Mass (Da):230,429
Last modified:November 28, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i674AAA4AB60520BD
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP003821 Genomic DNA Translation: AFR93442.1

NCBI Reference Sequences

More...
RefSeqi
XP_012047565.1, XM_012192175.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
AFR93442; AFR93442; CNAG_03942

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
23887397

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003821 Genomic DNA Translation: AFR93442.1
RefSeqiXP_012047565.1, XM_012192175.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

PTM databases

SwissPalmiJ9VGE0

Genome annotation databases

EnsemblFungiiAFR93442; AFR93442; CNAG_03942
GeneIDi23887397

Organism-specific databases

EuPathDBiFungiDB:CNAG_03942

Family and domain databases

InterProiView protein in InterPro
IPR040007 Tho2
IPR021418 THO_THOC2_C
IPR021726 THO_THOC2_N
IPR032302 THOC2_N
PANTHERiPTHR21597 PTHR21597, 1 hit
PfamiView protein in Pfam
PF11262 Tho2, 1 hit
PF11732 Thoc2, 1 hit
PF16134 THOC2_N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiJ9VGE0_CRYNH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: J9VGE0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 28, 2012
Last sequence update: November 28, 2012
Last modified: July 31, 2019
This is version 34 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again