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Protein

Inner capsid protein VP2

Gene

VP2

Organism
Rotavirus A
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Inner capsid protein that self-assembles to form an icosahedral capsid with a T=2 symmetry, which consists of 120 copies of VP2, with channels at each of its five-fold vertices. This capsid constitutes the innermost concentric layer of the viral mature particle. It encapsidates the polymerase VP1, the capping enzyme VP3 and the genomic dsRNA, thereby defining the core. The innermost VP2 capsid and the intermediate VP6 capsid remain intact following cell entry to protect the dsRNA from degradation and to prevent unfavorable antiviral responses in the host cell during all the replication cycle of the virus. Nascent transcripts are transcribed within the structural confines of this double-layered particle (DLP) and are extruded through the channels formed by VP2 N-termini. VP2 is required for the replicase activity of VP1 polymerase. Probably recruits a copy of a VP1-VP3 complex, potentially along with a segment of plus-strand RNA, as a decamer of VP2 assembles. May activate the autoinhibited VP1/RNA complex to coordinate packaging and genome replication.UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionRNA-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Inner capsid protein VP2UniRule annotation
Gene namesi
Name:VP2Imported
ORF Names:CM18_42392gpVP2Imported, CM18_42393gpVP2Imported
OrganismiRotavirus AImported
Taxonomic identifieri28875 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirus
Proteomesi

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Capsid protein, Inner capsid proteinUniRule annotation, Virion

Interactioni

Subunit structurei

Homodecamer; each decamer is made up of two conformers of VP2, called VP2A and VP2B. Interacts with a VP1-VP3 complex. Interacts with the intermediate capsid protein VP6. Interacts with NSP5. Interacts (via N-terminus) with NSP2.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the rotavirus VP2 family.UniRule annotation

Family and domain databases

InterProiView protein in InterPro
IPR007779 Rotavirus_VP2
PfamiView protein in Pfam
PF05087 Rota_VP2, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD008866 Rota_VP2, 1 hit

Sequencei

Sequence statusi: Complete.

J9V6R1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAYRKRGAKR ENLPQQNERL QEKEIEKDVD VTMENKNNNR KQQLSDKVLS
60 70 80 90 100
QKEEIITDAQ DDIKIAGEIK KSSKEESKQL LEILKTKEDH QKEIQYEILQ
110 120 130 140 150
KTIPTFESKE SILKKLEDIR PEQAKKQMKL FRIFEPKQLP IYRANGEKEL
160 170 180 190 200
RNRWYWKLKK DTLPDGDYDV REYFLNLYDQ ILIEMPDYLL LKDMAVENKN
210 220 230 240 250
SRDAGKVVDS ETANICDAIF QDEETEGVVR RFIADMRQQV QADRNIVNYP
260 270 280 290 300
SILHPIDHAF NEYFLNHQLV EPLNNEIIFN YIPERIRNDV NYILNMDMNL
310 320 330 340 350
PSTARYIRPN LLQDRLNLHD NFESLWDTIT TSNYILARSV VPDLKEKELV
360 370 380 390 400
STEAQIQKMS QDLQLEALTI QSETQFLAGI NSQAANDCFK TLIAAMLSQR
410 420 430 440 450
TMSLDFVTTN YMSLISGMWL LTVIPNDMFL RESLVACELA IINTIVYPAF
460 470 480 490 500
GMQRMHYRNG DPQTPFQIAE QQIQNFQVAN WLHFINNNRF RQVVIDGVLN
510 520 530 540 550
QTLNDNIRNG QVINQLMEAL MQLSRQQFPT MPVDYKRSIQ RGILLLSNRL
560 570 580 590 600
GQLVDLTRLV SYNYETLMAC VTMNMQHVQT LTTEKLQLTS VTSLCMLIGN
610 620 630 640 650
TTVIPSPQTL FHYYNINVNF HSNYNERIND AVAIITAANR LNLYQKKMKS
660 670 680 690 700
IVEDFLKRLQ IFDVPRVPDD QMYRLRDRLR LLPVERRRLD IFNLILMNME
710 720 730 740 750
QIERASDKIA QGVIIAYRDM QLERDEMYGY VNIARNLDGY QQINLEELMR
760 770 780 790 800
TGDYGQITNM LLNNQPVALV GALPFVTDSS VISLIAKLDA TVFAQIVKLR
810 820 830 840 850
KVDTLKPILY KINSDSNDFY LVANYDWIPT STTKVYKQVP QPFDFRASMH
860 870 880 890
MLTSNLTFTV YSDLLSFVSA DTVEPINAVA FDNMRIMNEL
Length:890
Mass (Da):103,751
Last modified:November 28, 2012 - v1
Checksum:i0E0933ED56EB4295
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JX406748 Genomic RNA Translation: AFR77807.1
KC580446 Genomic RNA Translation: AGE98551.1
KC580380 Genomic RNA Translation: AGE98623.1
KC580369 Genomic RNA Translation: AGE98635.1
KC580298 Genomic RNA Translation: AGE98713.1
KC580266 Genomic RNA Translation: AGE98746.1
KC580200 Genomic RNA Translation: AGE98818.1
KC580132 Genomic RNA Translation: AGE98893.1
KC580098 Genomic RNA Translation: AGE98930.1
KC579984 Genomic RNA Translation: AGE99048.1
KC579881 Genomic RNA Translation: AGE99153.1
KC579826 Genomic RNA Translation: AGE99210.1
KC579725 Genomic RNA Translation: AGE99320.1
KC579543 Genomic RNA Translation: AGE99514.1
KJ659454 Genomic RNA Translation: AHW80465.1
KJ659465 Genomic RNA Translation: AHW80477.1

Similar proteinsi

Entry informationi

Entry nameiJ9V6R1_9REOV
AccessioniPrimary (citable) accession number: J9V6R1
Entry historyiIntegrated into UniProtKB/TrEMBL: November 28, 2012
Last sequence update: November 28, 2012
Last modified: June 20, 2018
This is version 15 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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