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Protein
Submitted name:

Adenylate cyclase 9

Gene

ADCY9

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotationSAAS annotation
LigandNucleotide-bindingSAAS annotation

Enzyme and pathway databases

ReactomeiR-CFA-163359 Glucagon signaling in metabolic regulation
R-CFA-163615 PKA activation
R-CFA-164378 PKA activation in glucagon signalling
R-CFA-170660 Adenylate cyclase activating pathway
R-CFA-170670 Adenylate cyclase inhibitory pathway
R-CFA-418555 G alpha (s) signalling events
R-CFA-418597 G alpha (z) signalling events
R-CFA-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-CFA-5610787 Hedgehog 'off' state

Names & Taxonomyi

Protein namesi
Submitted name:
Adenylate cyclase 9Imported
Gene namesi
Name:ADCY9Imported
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)Imported
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 6

Organism-specific databases

VGNCiVGNC:37626 ADCY9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei116 – 136HelicalSequence analysisAdd BLAST21
Transmembranei142 – 164HelicalSequence analysisAdd BLAST23
Transmembranei176 – 198HelicalSequence analysisAdd BLAST23
Transmembranei242 – 261HelicalSequence analysisAdd BLAST20
Transmembranei788 – 809HelicalSequence analysisAdd BLAST22
Transmembranei821 – 845HelicalSequence analysisAdd BLAST25
Transmembranei866 – 884HelicalSequence analysisAdd BLAST19
Transmembranei890 – 910HelicalSequence analysisAdd BLAST21
Transmembranei922 – 939HelicalSequence analysisAdd BLAST18
Transmembranei976 – 995HelicalSequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiJ9P935

Expressioni

Gene expression databases

BgeeiENSCAFG00000019237 Expressed in 3 organ(s), highest expression level in liver

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000042267

Structurei

3D structure databases

ProteinModelPortaliJ9P935
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini394 – 521Guanylate cyclaseInterPro annotationAdd BLAST128
Domaini1057 – 1197Guanylate cyclaseInterPro annotationAdd BLAST141

Sequence similaritiesi

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3618 Eukaryota
COG2114 LUCA
GeneTreeiENSGT00760000119042
KOiK08049
OMAiFETNIHF

Family and domain databases

Gene3Di3.30.70.1230, 2 hits
InterProiView protein in InterPro
IPR001054 A/G_cyclase
IPR018297 A/G_cyclase_CS
IPR029787 Nucleotide_cyclase
PfamiView protein in Pfam
PF00211 Guanylate_cyc, 2 hits
SMARTiView protein in SMART
SM00044 CYCc, 2 hits
SUPFAMiSSF55073 SSF55073, 2 hits
PROSITEiView protein in PROSITE
PS00452 GUANYLATE_CYCLASE_1, 2 hits
PS50125 GUANYLATE_CYCLASE_2, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

J9P935-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASPPHQQLL QHHSTEVSCD SSGDSNSVRV KINPRQLSSN SHPKHCKYSI
60 70 80 90 100
SSSCSSSGDS GGVPRRAGAG GRLRRQKKLP QLFERASSRW WDPKFDSVNL
110 120 130 140 150
EEACMERCFP QTQRRFRYAL FYVGFACLLW SIYFGVHMRS RLIVMVAPAL
160 170 180 190 200
CFLVVCVGFF LFTFTKLYAR HYVWTSLVLT LLVFALTLAA QFQVLTPLSG
210 220 230 240 250
RVDSSNHTLA AKRTDTCLSQ VGSFSMCIEV LFLLYTVMHL PLYLSLFLGV
260 270 280 290 300
VYSVLFETFG YHFRDKDCFP PPGAGAPHWE LLSRALLHVC IHAIGIHLFI
310 320 330 340 350
MSQVRSRSTF LKVGQSIMHG KDLEVEKALK ERMIHSVMPR IIADDLMKQG
360 370 380 390 400
DEESENSVKR HATSSPKNRK KKSSIQKAPI AFRPFKMQQI EEVSILFADI
410 420 430 440 450
VGFTKMSANK SAHALVGLLN DLFGRFDRLC EETKCEKIST LGDCYYCVAG
460 470 480 490 500
CPEPRADHAY CCIEMGLGMI RAIEQFCQEK KEMVNMRVGV HTGTVLCGIL
510 520 530 540 550
GMRRFKFDVW SNDVNLANLM EQLGVAGKVH ISEATAKYLD DRYEMEDGKV
560 570 580 590 600
TERLGQSVVA DQLKGLKTYL IAGQRAKESH CSCTEALLSG FEVIDGSRVS
610 620 630 640 650
SGPRGQGTAS PGSVSDLAQT VKTFDNLKTC PSCGITFAPK SEAGAEGGAV
660 670 680 690 700
QNGGQEEHKN STKAPGAPNS KTQNGLLSPP QEEKLTNSQT SLCEILQEKG
710 720 730 740 750
RWAGVSLDQS ALLPLRFKNI REKTDAHFVD VIKEDSLMKD YFFKPPINEF
760 770 780 790 800
SLNFLDQELE RSYRTSYQEE VIKNSPVKTF ASATFSSLLD VFLSTTVFLI
810 820 830 840 850
LSITCFLKYG AAGTPPPPAA LAVFSAALLL EVLSLVVSVR MVFFLEDVMA
860 870 880 890 900
CTKRLLEWIA GWLPRHFIGA ILVSLPALAV YSHVTSEFET NIHFTVFTGS
910 920 930 940 950
AVLITVVHYC NFCQLSSWMR SSLATVVGAG PLLLLYISLC PDSSIVISHL
960 970 980 990 1000
DAGQNFSSEG NPCNNSLPRD GRTASLIGQE VILVFFLLLL LVWFLNREFE
1010 1020 1030 1040 1050
VSYRLHYHGD VEADLHRTKI QSMRDQADWL LRNIIPYHVA EQLKVSQTYS
1060 1070 1080 1090 1100
KNHDSGGVIF ASIVNFSEFY EENYEGGKEC YRVLNELIGD FDELLSRPGY
1110 1120 1130 1140 1150
SSIEKIKTIG ATYMAASGLN GAQCQDGSHP QEHLQVLFEF AKEMMRVVDD
1160 1170 1180 1190 1200
FNSNMLWFNF KLRVGFNHGP LTAGVIGTTK LLYDIWGDTV NIASRMDSTG
1210 1220 1230 1240 1250
VECRIQVSEE SYRVLSKMGY DFDYRGTVNV KGKGQMKTYL YPKCMDSGAV
1260 1270 1280 1290 1300
PQHQLSISPD IRVQVDGSIG RSPTDEIANL VPSVQNVDKT SLGSENNVLA
1310 1320 1330 1340 1350
KDTHLSSKRP WKEPVKAEER CRFGKAIEKS DCEEAGMEEA SELTRLNISK

SV
Length:1,352
Mass (Da):150,620
Last modified:October 31, 2012 - v1
Checksum:i4A35943BEC2B5C35
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E2R4W4E2R4W4_CANLF
Adenylate cyclase 9
ADCY9
1,352Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03004587 Genomic DNA No translation available.
RefSeqiXP_005621671.1, XM_005621614.1
XP_547151.2, XM_547151.3

Genome annotation databases

EnsembliENSCAFT00000044604; ENSCAFP00000042267; ENSCAFG00000019237
GeneIDi490031
KEGGicfa:490031

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03004587 Genomic DNA No translation available.
RefSeqiXP_005621671.1, XM_005621614.1
XP_547151.2, XM_547151.3

3D structure databases

ProteinModelPortaliJ9P935
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000042267

Proteomic databases

PaxDbiJ9P935

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000044604; ENSCAFP00000042267; ENSCAFG00000019237
GeneIDi490031
KEGGicfa:490031

Organism-specific databases

CTDi115
VGNCiVGNC:37626 ADCY9

Phylogenomic databases

eggNOGiKOG3618 Eukaryota
COG2114 LUCA
GeneTreeiENSGT00760000119042
KOiK08049
OMAiFETNIHF

Enzyme and pathway databases

ReactomeiR-CFA-163359 Glucagon signaling in metabolic regulation
R-CFA-163615 PKA activation
R-CFA-164378 PKA activation in glucagon signalling
R-CFA-170660 Adenylate cyclase activating pathway
R-CFA-170670 Adenylate cyclase inhibitory pathway
R-CFA-418555 G alpha (s) signalling events
R-CFA-418597 G alpha (z) signalling events
R-CFA-432040 Vasopressin regulates renal water homeostasis via Aquaporins
R-CFA-5610787 Hedgehog 'off' state

Gene expression databases

BgeeiENSCAFG00000019237 Expressed in 3 organ(s), highest expression level in liver

Family and domain databases

Gene3Di3.30.70.1230, 2 hits
InterProiView protein in InterPro
IPR001054 A/G_cyclase
IPR018297 A/G_cyclase_CS
IPR029787 Nucleotide_cyclase
PfamiView protein in Pfam
PF00211 Guanylate_cyc, 2 hits
SMARTiView protein in SMART
SM00044 CYCc, 2 hits
SUPFAMiSSF55073 SSF55073, 2 hits
PROSITEiView protein in PROSITE
PS00452 GUANYLATE_CYCLASE_1, 2 hits
PS50125 GUANYLATE_CYCLASE_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiJ9P935_CANLF
AccessioniPrimary (citable) accession number: J9P935
Entry historyiIntegrated into UniProtKB/TrEMBL: October 31, 2012
Last sequence update: October 31, 2012
Last modified: November 7, 2018
This is version 44 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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