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Entry version 57 (19 Jan 2022)
Sequence version 2 (11 Dec 2019)
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Protein
Submitted name:

Spectrin repeat containing nuclear envelope protein 1

Gene

SYNE1

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-bindingARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Spectrin repeat containing nuclear envelope protein 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SYNE1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCanis lupus familiaris (Dog) (Canis familiaris)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9615 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002254 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:47027, SYNE1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 8698CytoplasmicPROSITE-ProRule annotationAdd BLAST8698
Topological domaini8720 – 8749Perinuclear spacePROSITE-ProRule annotationAdd BLAST30

Keywords - Cellular componenti

Membrane, NucleusARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSCAFG00000000445, Expressed in cerebellum and 52 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 141Calponin-homology (CH)InterPro annotationAdd BLAST115
Domaini185 – 290Calponin-homology (CH)InterPro annotationAdd BLAST106
Domaini8690 – 8749KASHInterPro annotationAdd BLAST60

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni5788 – 5815DisorderedSequence analysisAdd BLAST28
Regioni8174 – 8210DisorderedSequence analysisAdd BLAST37
Regioni8623 – 8685DisorderedSequence analysisAdd BLAST63

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili334 – 354Sequence analysisAdd BLAST21
Coiled coili442 – 462Sequence analysisAdd BLAST21
Coiled coili636 – 656Sequence analysisAdd BLAST21
Coiled coili936 – 956Sequence analysisAdd BLAST21
Coiled coili1321 – 1348Sequence analysisAdd BLAST28
Coiled coili1420 – 1454Sequence analysisAdd BLAST35
Coiled coili1561 – 1581Sequence analysisAdd BLAST21
Coiled coili1636 – 1670Sequence analysisAdd BLAST35
Coiled coili1987 – 2014Sequence analysisAdd BLAST28
Coiled coili2021 – 2041Sequence analysisAdd BLAST21
Coiled coili2091 – 2111Sequence analysisAdd BLAST21
Coiled coili2243 – 2270Sequence analysisAdd BLAST28
Coiled coili2280 – 2300Sequence analysisAdd BLAST21
Coiled coili2348 – 2375Sequence analysisAdd BLAST28
Coiled coili2968 – 2988Sequence analysisAdd BLAST21
Coiled coili3167 – 3187Sequence analysisAdd BLAST21
Coiled coili3411 – 3438Sequence analysisAdd BLAST28
Coiled coili3472 – 3492Sequence analysisAdd BLAST21
Coiled coili3578 – 3598Sequence analysisAdd BLAST21
Coiled coili3606 – 3626Sequence analysisAdd BLAST21
Coiled coili3632 – 3652Sequence analysisAdd BLAST21
Coiled coili3674 – 3694Sequence analysisAdd BLAST21
Coiled coili3767 – 3787Sequence analysisAdd BLAST21
Coiled coili4036 – 4056Sequence analysisAdd BLAST21
Coiled coili4074 – 4094Sequence analysisAdd BLAST21
Coiled coili4203 – 4233Sequence analysisAdd BLAST31
Coiled coili4271 – 4291Sequence analysisAdd BLAST21
Coiled coili4644 – 4664Sequence analysisAdd BLAST21
Coiled coili4691 – 4735Sequence analysisAdd BLAST45
Coiled coili4779 – 4799Sequence analysisAdd BLAST21
Coiled coili4996 – 5016Sequence analysisAdd BLAST21
Coiled coili5034 – 5054Sequence analysisAdd BLAST21
Coiled coili5285 – 5312Sequence analysisAdd BLAST28
Coiled coili5434 – 5461Sequence analysisAdd BLAST28
Coiled coili5528 – 5548Sequence analysisAdd BLAST21
Coiled coili5556 – 5583Sequence analysisAdd BLAST28
Coiled coili5662 – 5689Sequence analysisAdd BLAST28
Coiled coili5700 – 5737Sequence analysisAdd BLAST38
Coiled coili5932 – 5952Sequence analysisAdd BLAST21
Coiled coili5987 – 6014Sequence analysisAdd BLAST28
Coiled coili6156 – 6183Sequence analysisAdd BLAST28
Coiled coili6455 – 6475Sequence analysisAdd BLAST21
Coiled coili6513 – 6537Sequence analysisAdd BLAST25
Coiled coili6986 – 7013Sequence analysisAdd BLAST28
Coiled coili7092 – 7122Sequence analysisAdd BLAST31
Coiled coili7741 – 7768Sequence analysisAdd BLAST28
Coiled coili8420 – 8440Sequence analysisAdd BLAST21
Coiled coili8594 – 8618Sequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi5791 – 5815Polar residuesSequence analysisAdd BLAST25
Compositional biasi8174 – 8196Polar residuesSequence analysisAdd BLAST23
Compositional biasi8623 – 8683Polar residuesSequence analysisAdd BLAST61

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the nesprin family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysisARBA annotation, RepeatARBA annotation, Transmembrane, Transmembrane helixARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154481

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000025_1_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
LWTSFRQ

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00014, CH, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR012315, KASH
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00307, CH, 2 hits
PF10541, KASH, 1 hit
PF00435, Spectrin, 11 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00033, CH, 2 hits
SM01249, KASH, 1 hit
SM00150, SPEC, 43 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47576, SSF47576, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00019, ACTININ_1, 1 hit
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits
PS51049, KASH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

J9P7I2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATSRTTSRS PRDIANVMQR LQDEQEIVQK RTFTKWINSH LAKRKPPLVV
60 70 80 90 100
DDLFEDMKDG VKLLALLEVL SGQKLPCEQG RRMKRIHAVA NIGTALKFLE
110 120 130 140 150
GRKSMYRGSP IKLVNINSTD IADGRPSIVL GLMWTIILYF QIEELTSNLP
160 170 180 190 200
QLQSLSGSTS SVDSMVSAET ASPPSKRKVA TKIQGNAKKA LLKWVQYTVA
210 220 230 240 250
KQTGTEVKDF GRSWRSGVAF HSVIHAIRPE LVDLEKVKGR SNRENLEEAF
260 270 280 290 300
TIAETELGIP RLLDPEDVDV DKPDEKSIMT YVAQFLKHYP DIHNTGTDGQ
310 320 330 340 350
ENDEILPGFP SFANSIQNFK REDRLILKET KVWIEQFERD LTRAQMTESN
360 370 380 390 400
LQDKYQSFKH FRVQYEIKRK QIEHLIQPVH RDGKLSLDQA LVKQSWDRVS
410 420 430 440 450
SRLFDWHIQL DKSLPAPLGT IGAWLYRAEV ALREEITIQQ VHEETANTIQ
460 470 480 490 500
RKREQHKDLL QNTDAHKRAF HEIYRTRSVN GIPVPPDQLE DMAERFHFVS
510 520 530 540 550
STSELHLMKM EFLELKYRLL SLLVLAESKL KSWIIKYGRR ESVELLLQNY
560 570 580 590 600
ISFIENTKFF EQYEVTYQIL KQTAEMYIQA DGSVEEAENV MKFMNETTAQ
610 620 630 640 650
WRNLSVEVRS VRSMLEEVIA NWDRYGNTVA SLQAWLEDAE KMLNQTEHAK
660 670 680 690 700
KDFFRNLPHW IQQHAAMNDA GNFLIETCDE MVSRDLKQQL LLLNGRWREL
710 720 730 740 750
FMEVKQYARA DELDRMKKEY TDCVNALSDF AMGAHKKLSE PLEVSFLNVK
760 770 780 790 800
LLIQDLEDIE QRVPVMDAQY KMITKTAHLI TKESSQEEAN EMFATMSGLK
810 820 830 840 850
EQLTKVKDCY SPLLYESQQL LIPLEELEKQ MTFFYDSVGK INEILTVLEH
860 870 880 890 900
EAQSSAVFKQ KQQELSACQE SCKKTMTQIE KGSQNVQKFM TLSSVLKHFD
910 920 930 940 950
QTKLHRQIAD AHGAFQNMMK KIGDWKKHVE TNSRLMKKFE ESRAELEKVL
960 970 980 990 1000
RIAQEGLEEK GNPEDLLRRH TEFFSQLDQR VLNAFLKACD ELTDILPEQE
1010 1020 1030 1040 1050
QQGLQEAVRK LHKQWKDLQG EAPYHLLHLK IDVEKNRFLA SVEECRTELD
1060 1070 1080 1090 1100
RETKLVPQEG SEKIIKEHRI FFSDKGPHHV CEKRLQLIEE LCLKLPGRDP
1110 1120 1130 1140 1150
VRNTPETCHV TLKELRAAID TTYMKLVEDP DKWKDYTSRI SQFSSWISAK
1160 1170 1180 1190 1200
ETELKGFKNE PIDTANHGKV KHAVEEIRND VTTKGETLNW LKSRLKVLIE
1210 1220 1230 1240 1250
VSSENEAQKQ GDELAKLSGS FKALVALLSE VEKMLSNFGD CVQYKEIVKS
1260 1270 1280 1290 1300
SLEELISGSK EIQEQAEKIL DTENLFEAQQ LLLHHQQKTK RISAKKRDVQ
1310 1320 1330 1340 1350
QQIEQAQQGE GGLPGQVREE LRKLESTLDN MEHSREKQER RIQVTLRKWE
1360 1370 1380 1390 1400
RFETNKETVV RYLFQTGSSH ERFLSYSSLE SLSSELEQTK EFSKRTEGIA
1410 1420 1430 1440 1450
VQAENLVKEA SEIPLGPKNK QLLQQQAKSI KEQVKKLEDT LEEDIKTMEM
1460 1470 1480 1490 1500
VKNKWDHFGN NFETLSIWIT EKEKELNALE TSSSAMDMQI HQIKVIIQEI
1510 1520 1530 1540 1550
QSKLSSITEL EESAQSFAQF VTTGESARIK AKLTQIRRYW EELREHAQCL
1560 1570 1580 1590 1600
EGTILGHLSQ QQKFEENLRK IQKSVSEFED KLADPVKICS SATETYKVLQ
1610 1620 1630 1640 1650
EHMDLCQALE ALSSTVATTS ASAQKVANRG SCVQEAAALQ QRYQEMQSQA
1660 1670 1680 1690 1700
KEKQTALEKL LAHWQRLEKE LSTFLTWLER CEAITSSPEM DISSDRVKVE
1710 1720 1730 1740 1750
SELQSIQALQ NEVVSQASVY SNLLQLKESL FSVASKDDVK MMKLHLEQLD
1760 1770 1780 1790 1800
ERWRDLPQII SKRIAFLQSV VAEHQQFDEL LLSLSVWIKL FLSELQSTSE
1810 1820 1830 1840 1850
ISITDHQAAF TRHKDHAAEV ESKKGELQSL QDHLVKLGAL VRAESLPLLQ
1860 1870 1880 1890 1900
GKAEDCFQLF EEASQVVERR QLALAQLAEF LQSHVSLSGV LHRLRHTVEA
1910 1920 1930 1940 1950
TNSMNRKQTD LLEKDLNHAI QDAKSLESVA ISLDSVLAKA QYHLKSGSSE
1960 1970 1980 1990 2000
QRTSCRTTAD HLCSELERIQ NLLGIKQSEA DALAVLKKAF QDQKEELLKS
2010 2020 2030 2040 2050
IEDIEERTDK ERLKELTRQA LQQRLRVFNQ LEDELNSHEH ELCWLKDKAK
2060 2070 2080 2090 2100
QIAQKDVAFA SEVDREVNRL EVTWDDTKKL IHENQGQCCG LIDLIREYQN
2110 2120 2130 2140 2150
LKSAVSKVLE NASNVIATRT TIKDQEDLKW ALSKHETAKN EMCNEQKELD
2160 2170 2180 2190 2200
FTSKGKQLLF ELKKIHSSDF ILVKTDMDST VDRWLDISEK IEENMDRLRV
2210 2220 2230 2240 2250
SLTIWADVLS SKDEIDGWCN SSVPRLAESI SNLNNSLRAE EFLKEFESEV
2260 2270 2280 2290 2300
KNKALRLEEL HCKVNDLKEL TKNPETPPDL QFVEADLRQK LEHAKEITEE
2310 2320 2330 2340 2350
AKGTLKDFTA QSTQVEKFIN DITSWLTKVE ESLMNCAQTE TWEGLKKVKE
2360 2370 2380 2390 2400
IQKELQSQQS NISSTQENLN SLCRKYHSVE LESLGSALTG LIKNQEAVSQ
2410 2420 2430 2440 2450
LCSKTQASLQ DSLVKHFNES MQEFQEWFSG IKTAAKESSD RTGDSKVLEA
2460 2470 2480 2490 2500
KLHNLQNILD SISDGQSKLD AVTQEGQTLY AHVSKQIVGS IQEKITKANE
2510 2520 2530 2540 2550
EFQAFLKQCL KDKQTLQDCA LELGSFEDQH RKLNLWIHEM DERLSTENLG
2560 2570 2580 2590 2600
ESKQHIPEKK NEVHKVEMFL GELLAARESL DKLSQRGQLL SEEGHGAGKE
2610 2620 2630 2640 2650
GRLCSQLLTN YQNLLRMTKE KLRSCQVALQ EHEALEEALQ SMWSWVKAIQ
2660 2670 2680 2690 2700
DRLAGAESTI GSKDTLEKRL LQIQDILLMK GEGEVKLNMA IGKGEQALRS
2710 2720 2730 2740 2750
SNKQGQKVIQ TQLQTLKDVW ADIMSSSVHA QSTLESVISK WNDYLEWRNQ
2760 2770 2780 2790 2800
LEQWMESVDQ KIEHPLQLQP GLKEKFSLLD HFQSIVSEAE DHAGALQHLT
2810 2820 2830 2840 2850
SKSRELYQKT ENESFKETAQ EELKTQFNDI ITVSKEKMRK AEEIVKDHLM
2860 2870 2880 2890 2900
YLDAVQEFTD WLHSAKEELH RWSDMSGDSS ATQKKLSKIK ELMDSREIGA
2910 2920 2930 2940 2950
SRLSRVELLA PTVKQNTSAS GCELVDTEMQ ALRADWKQWE DSVVQTQTSL
2960 2970 2980 2990 3000
ENLVSQMALS EQEFSGQVAQ LEQALEQFSA LLTTWAQQLA LLEGKNTDKE
3010 3020 3030 3040 3050
IVECWQKGQE ILDALQKAEP KTEDLKSQLN ELCRFSRDLS TYSGKVSSLI
3060 3070 3080 3090 3100
KEYNCLCLQA SKGCQNREQI LQQRFRRAFK DFQQWLVNAK ITTAKCFDIP
3110 3120 3130 3140 3150
QNINEVSTNL QKIQEFLSES ENGQHKLNMM LSKGELLSTL LTKEKADGIQ
3160 3170 3180 3190 3200
AKVVTAKEDW KNFHSNLHQK ESALENLKIQ MKDFEVSAEP VQDWLSKTEK
3210 3220 3230 3240 3250
LVQESSNRLY DLPAKRREQQ KLQSVLEEIN CYEPQLNRLR EKAQQLWEGQ
3260 3270 3280 3290 3300
AASKSFMHRV SQLSSQYLAL SNLTKEKVSR LDRIVAEHNQ FSLGIKELQD
3310 3320 3330 3340 3350
WLTDAVHMLD SYCHPTSDKS VLDSRMLKLE ALLSVKQEKE IQMKMIVTRG
3360 3370 3380 3390 3400
ESVLQNTSPE GIPAIQQQLQ SVKDMWASLL SAAIRCKSQL EGALSKWTSY
3410 3420 3430 3440 3450
QDDVRQFSGW MDSMEASLNE SERQYAELRE KTSALGKAKL LSEEVLSYSS
3460 3470 3480 3490 3500
LLETIELKGA GMTEHYVTQL EFQDLQERYR TIKERAKEAV TKSEKLVRLH
3510 3520 3530 3540 3550
QEYQRDLKAF EVWLGQEQEN LDRHSVLEGD AHTHETTLRD LQELQVRCAE
3560 3570 3580 3590 3600
GQALLNSVLH TREEVIPSGI PQTEDRALES LRQDWQAYQQ RLTETRTQFN
3610 3620 3630 3640 3650
NVVNKLRLME QKYQQVDEWL KTLENKKWHE EVTAYKDEVE EVGARAQEML
3660 3670 3680 3690 3700
DENHVSSRMG CQATQLTSRY QALLLQVLEQ IKFLEEEIQS LEESELSLNS
3710 3720 3730 3740 3750
YSDWYTSTHK NFKNVATKID RVDKAMMGKK MKMLEGLLKD MEKGHSLLKS
3760 3770 3780 3790 3800
TREKGERALK YLEDSEAETL RNEIHEHMEQ LKELTSTVRK EHMTLEKGLL
3810 3820 3830 3840 3850
LAKEFSDKYK ALTQWISEYQ EILHTPEEPK MELYEKKAQL SKYKSLQQMV
3860 3870 3880 3890 3900
LSHEPSVKSV REKGEALLEL VQDVTLKDEI DKLQSDYKDL CDAGKAMMEE
3910 3920 3930 3940 3950
IAGFEDRLNN LKIKGDNLIS QCADHLQAKL KQNVHAHLQG TSDSYSAICS
3960 3970 3980 3990 4000
TAQRVYQSLE HELQKHVSRQ DTLQQCQAWL SAVQPDLKPS QLPPLSRAEA
4010 4020 4030 4040 4050
VKQVKHFRAL QEQARTYLDL LCSMCDLSNS SVKTTAKDIQ QTEQMIEQRL
4060 4070 4080 4090 4100
AQAQNLTQGW GEIKHMKAEL WIYLQDADQQ LQNMKRRHSE LELNIAQNMV
4110 4120 4130 4140 4150
SQVKDFVKKL QCKQASVTAI TERVNKLTKK QESPEHKEIS HLNDQWLDLC
4160 4170 4180 4190 4200
LQSNNLCLQR EEDLQRTRDY HDCMNVVEVF LEKFTTEWDN LARSDAESTA
4210 4220 4230 4240 4250
VHLEALKKLA LALQERKQAI EDLKDQKQKM IEHLNLDDKE LVKEQTSHLE
4260 4270 4280 4290 4300
QRWFQLEDLV KRKIQVSVTN LEELNVVRSR FQELMEWAEE QQPNISEALK
4310 4320 4330 4340 4350
QSPPPDVAQN LLMDHLAICS ELEAKQMLLK SLIKDADRVM ADLGLNERQI
4360 4370 4380 4390 4400
IQKALSDAQS HVNCLSDLVG QRRKYLNKAL SEKTQFLMAV FQATSQIQQH
4410 4420 4430 4440 4450
ERKIMFREHI CLLPDDVSKQ VKTCKSAQAS LKTYQNEVTG LWAQGRELMK
4460 4470 4480 4490 4500
GATEQEKSEI LGKLQELQSV YDTVLQKCSH RLQELEKNLV SRKHFKEDFD
4510 4520 4530 4540 4550
KACHWLKQAD IVTFPEINLM NESAELHTQL AKYQHILEQS PEYENLLLTL
4560 4570 4580 4590 4600
QRTGQAILPS LNEVDHSYLN EKLNALPLQF NVVVALAKDK FYKVQEAILA
4610 4620 4630 4640 4650
RKEYASLIEL TTQSLSELED QFLKMNKVPT DLIVEEALSL QDGCRALLRE
4660 4670 4680 4690 4700
VSGLGEAVDE LNQKKESFRS TGQPWQPDKM LHLVTLYHRL KRQAEQRVNL
4710 4720 4730 4740 4750
LEDTTSAYQE HEKMCHQLEK QLEAVKTEQS KVNEETLPAE EKLKMYHSLA
4760 4770 4780 4790 4800
GSLQDSEIIL KRVTVHLEDL VPHLDPLAYE KAKQQIQSWQ EELKLLTSAI
4810 4820 4830 4840 4850
GATVTECESR MVQSIDFQTE LSRSLDWLRS VKAELSGPVC LELSLQDIQE
4860 4870 4880 4890 4900
EIRKIQIHQE EVQSSLRIMN ALSNKEKEKF TKAKELISAD LQHTLAELSE
4910 4920 4930 4940 4950
LDGDIQEALR TRQAALTQIY SQCQRYYQVF QAANDWLEDA HEMLQLAGNG
4960 4970 4980 4990 5000
IDVESAEENL KSHMEFFSTE DQFHRNLEEL QGLVASLDPL IKPTGKEDLA
5010 5020 5030 5040 5050
QKMASLEDKS QRIIQDSHAQ LDLLQRCAAQ WQDYQKAREE VIELMNDAEK
5060 5070 5080 5090 5100
KLSEFSLSKT SSSHEAEEKL SEHKSLVSVV NSFHEKVVAL EDKTSQLEKT
5110 5120 5130 5140 5150
GNDASKAAIS RSMTTVWQRW TRLRAVAQDQ EKILEDAVDE WKSFNNKVKK
5160 5170 5180 5190 5200
ATEIIDQLQD KLPGSSAEKA SKAELLTLLD FHDTLILELE QQQLALGLLR
5210 5220 5230 5240 5250
QQALSMLQDG ATKSPGEEPS IVQEITTMQD RCLNMQEKVK SNGKVVKQEL
5260 5270 5280 5290 5300
KEREVVETQI NSVKSWVQET KEYLGNPTIE IDAQLEELQI LLTEATNRRQ
5310 5320 5330 5340 5350
NIEKMTEEQK NKYLGLYSIL PSEVSLQLAE VALDLGTIHD QIQDKVREVE
5360 5370 5380 5390 5400
QSKAMSQEFS RQIQKIAKDL TTILSKLRAK TDNLAQAKSD QKVLGEELDG
5410 5420 5430 5440 5450
CNLKLMELDA AVQKFSEQNG QLGKPLAKKI GKLTELHQQT IRQAENRLSK
5460 5470 5480 5490 5500
LSQAASHLEE YNEMLEFILK WIEKAKVLVH GKITWNSANQ LREQYVLHQT
5510 5520 5530 5540 5550
MLEESEEIHS NLEAMIVKLQ YLASVYSTEK MSQQVAELGR ESEELRQMIK
5560 5570 5580 5590 5600
IRMHNLQDAA KDMKKFETEL KNLQVALEQA QTTLTSPEVG RLSLKEQLSH
5610 5620 5630 5640 5650
RQHLLSEMES LKPKVHAVQI CQSALRIPED VVTSLPLCHA ALHLQEEASR
5660 5670 5680 5690 5700
LQHTAIQQCN IMQASVVQYE QYEQEMQHLR ELIEGAHREI EDTPVATSNI
5710 5720 5730 5740 5750
QELQAQISRH EELAQKIKGY QEQIASLNSK CKMLTMKAKH ATMLLTVTEV
5760 5770 5780 5790 5800
EGLAEGTEDL DRELLPATSA HPSVVMMTAG RCHTLLSPVT EESGEEGTNS
5810 5820 5830 5840 5850
EISSPPACRS PSPVANADAS VNQDIAYYQA LSAERLQTDA ARIHPSTLPS
5860 5870 5880 5890 5900
QEFYEPGLEP SATAKLDDLQ RSWETLKNVI SEKQRTLYEA LERQQKYQDS
5910 5920 5930 5940 5950
LQSISTKMEA IEMKLSESLE HGRSPESQMA EHQALMDEIL MLQDEISELQ
5960 5970 5980 5990 6000
SSLAEELVSE SPESDPAEQL ALQSTLTVLA ERMSTIKMKA SGKRQLLEEK
6010 6020 6030 6040 6050
LNDQLEEQRQ EQALQRYRCE ADELDHWLLS TKATLDTALG TAKEPMDMEA
6060 6070 6080 6090 6100
QLVDCQNMLL EIEQKVVALS ELSVHNDNLL LEGKAHTKEE AEQLAIKLRV
6110 6120 6130 6140 6150
LKGSLLELQR ALHDKQLNIQ GTAQEKEESH VDLTASQSPG VQEWLAQART
6160 6170 6180 6190 6200
TWTHQRQSSL QQQKELEQEL AEQKSLLRSV ASRGEEILTQ HSAAETSGGA
6210 6220 6230 6240 6250
GEKPDVLSQE LGMEGEKSAA EDQMRMKWES LHQEFSTKQK LLQNVLEQEQ
6260 6270 6280 6290 6300
EQLLYSRPNR LLSGVPLYKG DGQTQDKSAV TSLLDGLNQV FEEVSSQSGG
6310 6320 6330 6340 6350
KKRQNIHLEQ KLYDGVSATS TWLDDVEERL FVATALLPEE TEACLFNQET
6360 6370 6380 6390 6400
LAKDIKEMSE EMDKNRNLFS QAFPENGDNR DVIEDTLGCL LGRLSLLDSV
6410 6420 6430 6440 6450
VNQRCHQMKE RLQQILNFQN DLKVLCTSLA DNKYIILQKL ANVFEQPVAE
6460 6470 6480 6490 6500
QIEAIQQAED GLKELDAGII ELKRRGDKLQ IEQPSMQELS KLQDMYDELM
6510 6520 6530 6540 6550
MTIGSRRSGL NQNLALKSQY ERALQDLADL LETGQEKMAG DQKIIVSSKE
6560 6570 6580 6590 6600
EIQQLLDKHK EYFQGLESHM ILTETLFRKI ISFAVPQETQ FHTELMAQAS
6610 6620 6630 6640 6650
AVLKRAHKRG VELEYILETW SHLDEDYQEL SRQLEVVESS IPSVGLVEES
6660 6670 6680 6690 6700
EDRLIDRIAL YQHLKSSLNE YQPKLYQVLD DGKRLLISIS CSDLEGQLNQ
6710 6720 6730 6740 6750
LGEHWLNNTN KVSKELHRLE TVLKHWTRYQ SESAELIHWL QSAKDRLEFW
6760 6770 6780 6790 6800
TQQSVTVPQE LEMVRDHLNA FLEFSKEVDA KSSLKSSVLS TGNQLLRLKK
6810 6820 6830 6840 6850
VDTAALRSEL SHIDSQWTDL LTNIPTVQEK LHQLQMDKLP SRHAISEVMT
6860 6870 6880 6890 6900
WISLMENVIQ KDEENIQNSV GYKAIHEYLQ KYKGFKIDIN CKQLTVDFVN
6910 6920 6930 6940 6950
QSVLQISSQD VESKRSDKTD FAEQLGAMNK SWQILQGLVT EKIQLLEGLL
6960 6970 6980 6990 7000
ESWSEYENNV QSLKTWYETQ ENRLKQQHRI GDQASVQNAM KDCQDLEDLV
7010 7020 7030 7040 7050
KAKEKEVERI EQSGLALIQN KKEEVSGIVM STLRELNQTW ANLDHMVGQL
7060 7070 7080 7090 7100
KILLKSVFDQ WNNHKVAFDE INTYLMEARY SLSRFRLLTG SLEAVQVQVD
7110 7120 7130 7140 7150
NLQNLQDDLE KQEKNLQRFG SITNQLLKEC HPPVTETLTN TLKDVNMRWN
7160 7170 7180 7190 7200
NLLEEIAEQL HSSKALLQLW QRYKDYSQQC ASTVQQQEDR TNELLKAATN
7210 7220 7230 7240 7250
KDIADDEAAT WIQDCNDLLK GLGIVKDSLF VLHELGEQLK QQVDASAASA
7260 7270 7280 7290 7300
IQSDQLSLSQ HLCALEQALC KQQTTLQVGV LDYETFTKSL EALEAWIVEA
7310 7320 7330 7340 7350
EDILQGQDPS HSSDLSTIQE RMEELKGQML KFSSMVPDLD RLNELGYRLP
7360 7370 7380 7390 7400
LNDKEIKRMQ NLNRRWSLIS SQTTERFSKL QSFLLQHQTF LEKCETWMEF
7410 7420 7430 7440 7450
LVQTEQKLAV EISGNYQHLL EQQRAHELFQ AEMFSRQQIL HSIIIDGQRL
7460 7470 7480 7490 7500
LEQGQVDDRD EFNLKLTLLS NQWQGVIRRA QQRRGIIDSQ IRQWQRYREM
7510 7520 7530 7540 7550
AEKLRKWLVE VSYLPVSALG SVPIPLQQAR TLFDEVQFKE KVFLRQQGSY
7560 7570 7580 7590 7600
ILTVEAGKQL LLSADSGAEA ALQAELTEIQ EKWKSASVRL EEQKKKLAFL
7610 7620 7630 7640 7650
LKDWENCENG IADSLEKLRT FKKKLSQPLP DHHEELHAEQ MRCKELENVA
7660 7670 7680 7690 7700
GSWTDDMAQL TLLKDTLCAY ISADDISILN ERMELLQRQW EELCHQLSLR
7710 7720 7730 7740 7750
RQQVSERLNE WAVFSEKNKE LCEWLTQMES KVSQNGDILI EDMIEKLKKD
7760 7770 7780 7790 7800
YQEEIAVAQE NKIQLQQMGE RLARASHESK ASEIEYKLGK VNDRWQHLLD
7810 7820 7830 7840 7850
LMAARVKKLK ETLVAVQQLD KNMSSLRTWL AHIESELAKP IVYDSCDSDE
7860 7870 7880 7890 7900
IQKKLTEQQE LQRDIEKHST GVASVLNLCE VLLHDCDACA TDAECDSIQQ
7910 7920 7930 7940 7950
ATRNLDRRWR NICAMSMERR LKIEETWRLW QKFLDDYSRF EDWLKISERT
7960 7970 7980 7990 8000
AAFPSSSGVL YTVAKEELKK FEAFQRQVHE SLTQLELINK QYRRLARENR
8010 8020 8030 8040 8050
TDSACSLKQM VHEGNQRWDN LQKRVTSILR RLKHFIGQRE EFETARDSIL
8060 8070 8080 8090 8100
VWLTEMDLQL TNIEHFSECD VQAKIKQLKA FQQEISLNHN KIEHIIAQGE
8110 8120 8130 8140 8150
QLIEKSEPLD AAVIEEELDE LRRYCQEVFG RVERYHKKLI RLPLPDDDHD
8160 8170 8180 8190 8200
LSDRELELDD SAALSDLHWR DTSADSVLSP QPSSNPSLSL AQPLRSERSG
8210 8220 8230 8240 8250
RDTPASVDSI PLEWDHDYDL SRDLESAVSR TLPSEDEEGQ DDKDFYLRGA
8260 8270 8280 8290 8300
VGLSDVMIPE SPEAYVKLTE SAIRNTSGAP SALESQIRQL DKALDESRFQ
8310 8320 8330 8340 8350
MQQTENIIRS KTPTGPELDS SYRGYMKLLG ECSGSIDSVK RLEHKLREEE
8360 8370 8380 8390 8400
ENFPGFVNLN STETQTAGVI DRWELIQAQA LSKELRMKQN LQKWQQFNSD
8410 8420 8430 8440 8450
LNNIWTWLGE TEEELEQLQR LELSTDIQAI ELQIKKLKEL QKAVDHRKAL
8460 8470 8480 8490 8500
ILSINLCSSE FTQTDSEKSQ DLQDRLSQMN GRWDHVCSLL EEWRGLLQDA
8510 8520 8530 8540 8550
LMQCQDFHEM SHGLLLMLEN IDRRKNEIVP IDSNQDAETL QDHHKQLMQI
8560 8570 8580 8590 8600
RHELLESQLK VASLQDMSCQ LLVNAEGTDC LEAKEKVHVI GNRLKLLLKE
8610 8620 8630 8640 8650
VSRHIKELEK LLDMSSSQQD LSSWSSADEL DTSGSVSPTS GRSTPNRQRT
8660 8670 8680 8690 8700
PRGKCSLSQP GPSVNSPHSR SIKGGSDSSL SEPRPARSGR AFLFRVLRAA
8710 8720 8730 8740
LPLQLLLLLL IGLACLVPMS EEDYSCALSN NFARSFHPML RYTNGPPPL
Length:8,749
Mass (Da):1,005,474
Last modified:December 11, 2019 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA35AC46809F23DB8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1PER7F1PER7_CANLF
Spectrin repeat containing nuclear ...
SYNE1
8,797Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F4D7I1A0A5F4D7I1_CANLF
Spectrin repeat containing nuclear ...
SYNE1
975Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F1PE19F1PE19_CANLF
Spectrin repeat containing nuclear ...
SYNE1
1,433Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAEX03000277 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSCAFT00000043078; ENSCAFP00000041619; ENSCAFG00000000445

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03000277 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSCAFT00000043078; ENSCAFP00000041619; ENSCAFG00000000445

Organism-specific databases

VGNCiVGNC:47027, SYNE1

Phylogenomic databases

GeneTreeiENSGT00940000154481
HOGENOMiCLU_000025_1_0_1
OMAiLWTSFRQ

Gene expression databases

BgeeiENSCAFG00000000445, Expressed in cerebellum and 52 other tissues

Family and domain databases

CDDicd00014, CH, 2 hits
Gene3Di1.10.418.10, 2 hits
InterProiView protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR012315, KASH
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat
PfamiView protein in Pfam
PF00307, CH, 2 hits
PF10541, KASH, 1 hit
PF00435, Spectrin, 11 hits
SMARTiView protein in SMART
SM00033, CH, 2 hits
SM01249, KASH, 1 hit
SM00150, SPEC, 43 hits
SUPFAMiSSF47576, SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS00019, ACTININ_1, 1 hit
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits
PS51049, KASH, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiJ9P7I2_CANLF
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: J9P7I2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 31, 2012
Last sequence update: December 11, 2019
Last modified: January 19, 2022
This is version 57 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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