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Entry version 37 (05 Jun 2019)
Sequence version 1 (31 Oct 2012)
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Protein
Submitted name:

Pre-mRNA processing factor 40 homolog A

Gene

PRPF40A

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Pre-mRNA processing factor 40 homolog AImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PRPF40AImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCanis lupus familiaris (Dog) (Canis familiaris)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9615 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002254 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:45026 PRPF40A

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSCAFG00000005827 Expressed in 3 organ(s), highest expression level in liver

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
J9P4S4

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini113 – 146WWInterPro annotationAdd BLAST34
Domaini159 – 187WWInterPro annotationAdd BLAST29
Domaini366 – 420FFInterPro annotationAdd BLAST55
Domaini433 – 487FFInterPro annotationAdd BLAST55
Domaini500 – 560FFInterPro annotationAdd BLAST61
Domaini580 – 640FFInterPro annotationAdd BLAST61
Domaini645 – 700FFInterPro annotationAdd BLAST56
Domaini715 – 772FFInterPro annotationAdd BLAST58

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 31DisorderedSequence analysisAdd BLAST31
Regioni216 – 236DisorderedSequence analysisAdd BLAST21
Regioni311 – 359DisorderedSequence analysisAdd BLAST49
Regioni705 – 724DisorderedSequence analysisAdd BLAST20
Regioni776 – 930DisorderedSequence analysisAdd BLAST155

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili419 – 446Sequence analysisAdd BLAST28
Coiled coili551 – 583Sequence analysisAdd BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 17PolarSequence analysisAdd BLAST17
Compositional biasi222 – 236PolarSequence analysisAdd BLAST15
Compositional biasi311 – 339PolarSequence analysisAdd BLAST29
Compositional biasi341 – 359PolyampholyteSequence analysisAdd BLAST19
Compositional biasi780 – 800BasicSequence analysisAdd BLAST21
Compositional biasi801 – 839PolyampholyteSequence analysisAdd BLAST39
Compositional biasi840 – 854BasicSequence analysisAdd BLAST15
Compositional biasi855 – 900PolyampholyteSequence analysisAdd BLAST46
Compositional biasi910 – 930PolyampholyteSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00930000150980

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00201 WW, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.440, 5 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002713 FF_domain
IPR036517 FF_domain_sf
IPR039726 Prp40-like
IPR001202 WW_dom
IPR036020 WW_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11864 PTHR11864, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01846 FF, 5 hits
PF00397 WW, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00441 FF, 5 hits
SM00456 WW, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51045 SSF51045, 2 hits
SSF81698 SSF81698, 5 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51676 FF, 6 hits
PS01159 WW_DOMAIN_1, 2 hits
PS50020 WW_DOMAIN_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

J9P4S4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCSGSGRRRS SLSPTMRPGT GAERGGLMMG HPGMHYAPMG MHPMGQRANM
60 70 80 90 100
PPVPHGMMPQ MMPPMGGPPM GQMPGMMSSV MPGMMMSHMS QASMQPALPP
110 120 130 140 150
GVNNMDVAAG TASGAKSMWT EHKSPDGRTY YYNTETKQST WEKPDDLKTP
160 170 180 190 200
AEQLLSKCPW KEYKSDSGKP YYYNSQTKES RWAKPKELED LEGYQNTIVA
210 220 230 240 250
GSLITKSNLH AMIKAEESSK QEECTTTSTA PVPTTEIPTT MSTMAAAEAA
260 270 280 290 300
AAVVAAAAAA AAAAAAANAS ASTSASNTVG GTGPVVPEPE VTSIVATVVD
310 320 330 340 350
NENTMTISTE EQAQLTSTPA VQDQSMEVSS NTGEEAAKQE TVSDFTPKKE
360 370 380 390 400
EEESQPAKKT YTWNTKEEAK QAFKELLKEK RVPSNASWEQ AMKMIINDPR
410 420 430 440 450
YSALAKLSEK KQAFNAYKVQ TEKEEKEEAR SKYKEAKESF QRFLENHEKM
460 470 480 490 500
TSTTRYKKAE QMFGEMEVWN AISERDRLEI YEDVLFFLSK KEKEQAKQLR
510 520 530 540 550
KRNWEALKNI LDNMANVTYS TTWSEAQQYL MDNPTFAEDE ELQNMDKEDA
560 570 580 590 600
LICFEEHIRA LEKEEEEEKQ KSLLRERRRQ RKNRESFQIF LDELHEHGQL
610 620 630 640 650
HSMSSWMELY PTISSDIRFT NMLGQPGSTA LDLFKFYVED LKARYHDEKK
660 670 680 690 700
IIKDILKDKG FVVEVNTTFE DFVAIISSTK RSTTLDAGNI KLAFNSLLEK
710 720 730 740 750
AEAREREREK EEARKMKRKE SAFKSMLKQA TPPIELDAVW EDIRERFVKE
760 770 780 790 800
PAFEDITLES ERKRIFKDFM HVLEHECQHH HSKNKKHSKK SKKHHRKRSR
810 820 830 840 850
SRSGSDSDDD DSHSKKKRQR SESRSASEHS SSAESERSYK KSKKHKKKSK
860 870 880 890 900
KRRHKSDSPE SDAEREKDKK EKDRESEKDR TRQRSESKHK SPKKKTGKDS
910 920 930
GNWDTSGSEL SEGELEKRRR TLLEQLDDDQ
Length:930
Mass (Da):105,905
Last modified:October 31, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i62E0944C955466F8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E2R5V6E2R5V6_CANLF
Pre-mRNA processing factor 40 homol...
PRPF40A
959Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J9P1Z6J9P1Z6_CANLF
Pre-mRNA processing factor 40 homol...
PRPF40A
860Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAEX03011986 Genomic DNA No translation available.
AAEX03011987 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSCAFT00000043383; ENSCAFP00000040597; ENSCAFG00000005827

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03011986 Genomic DNA No translation available.
AAEX03011987 Genomic DNA No translation available.

3D structure databases

SMRiJ9P4S4
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000043383; ENSCAFP00000040597; ENSCAFG00000005827

Organism-specific databases

VGNCiVGNC:45026 PRPF40A

Phylogenomic databases

GeneTreeiENSGT00930000150980

Gene expression databases

BgeeiENSCAFG00000005827 Expressed in 3 organ(s), highest expression level in liver

Family and domain databases

CDDicd00201 WW, 2 hits
Gene3Di1.10.10.440, 5 hits
InterProiView protein in InterPro
IPR002713 FF_domain
IPR036517 FF_domain_sf
IPR039726 Prp40-like
IPR001202 WW_dom
IPR036020 WW_dom_sf
PANTHERiPTHR11864 PTHR11864, 1 hit
PfamiView protein in Pfam
PF01846 FF, 5 hits
PF00397 WW, 2 hits
SMARTiView protein in SMART
SM00441 FF, 5 hits
SM00456 WW, 2 hits
SUPFAMiSSF51045 SSF51045, 2 hits
SSF81698 SSF81698, 5 hits
PROSITEiView protein in PROSITE
PS51676 FF, 6 hits
PS01159 WW_DOMAIN_1, 2 hits
PS50020 WW_DOMAIN_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiJ9P4S4_CANLF
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: J9P4S4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 31, 2012
Last sequence update: October 31, 2012
Last modified: June 5, 2019
This is version 37 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health

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