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Entry version 34 (05 Jun 2019)
Sequence version 1 (31 Oct 2012)
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Protein
Submitted name:

Zinc finger protein 541

Gene

ZNF541

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Zinc finger protein 541Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF541Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCanis lupus familiaris (Dog) (Canis familiaris)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9615 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002254 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:48757 ZNF541

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusSAAS annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSCAFG00000004103 Expressed in 1 organ(s), highest expression level in prefrontal cortex

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
J9NY16

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini141 – 168C2H2-typeInterPro annotationAdd BLAST28
Domaini169 – 196C2H2-typeInterPro annotationAdd BLAST28
Domaini833 – 860C2H2-typeInterPro annotationAdd BLAST28
Domaini1075 – 1167ELM2InterPro annotationAdd BLAST93
Domaini1182 – 1233SANTInterPro annotationAdd BLAST52
Domaini1313 – 1340C2H2-typeInterPro annotationAdd BLAST28

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 35DisorderedSequence analysisAdd BLAST35
Regioni115 – 137DisorderedSequence analysisAdd BLAST23
Regioni236 – 269DisorderedSequence analysisAdd BLAST34
Regioni289 – 310DisorderedSequence analysisAdd BLAST22
Regioni435 – 533DisorderedSequence analysisAdd BLAST99
Regioni571 – 661DisorderedSequence analysisAdd BLAST91
Regioni680 – 725DisorderedSequence analysisAdd BLAST46
Regioni947 – 979DisorderedSequence analysisAdd BLAST33
Regioni1246 – 1311DisorderedSequence analysisAdd BLAST66

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi21 – 35PolarSequence analysisAdd BLAST15
Compositional biasi447 – 461PolarSequence analysisAdd BLAST15
Compositional biasi495 – 509PolyampholyteSequence analysisAdd BLAST15
Compositional biasi585 – 600Pro-richSequence analysisAdd BLAST16
Compositional biasi1246 – 1284PolyampholyteSequence analysisAdd BLAST39

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
KOG4167 Eukaryota
ENOG4110BKZ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160330

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000949 ELM2_dom
IPR009057 Homeobox-like_sf
IPR001005 SANT/Myb
IPR017884 SANT_dom
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01448 ELM2, 1 hit
PF00096 zf-C2H2, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01189 ELM2, 1 hit
SM00717 SANT, 1 hit
SM00355 ZnF_C2H2, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689 SSF46689, 1 hit
SSF57667 SSF57667, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51156 ELM2, 1 hit
PS51293 SANT, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

J9NY16-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDQYSLGDEG ALPPEMHLPS FSESQGLNCS DTLNRDLGPS TRDLLYAGLS
60 70 80 90 100
GLDLDSSLPT PDMPSEALED NLDTLSLYSG KDSDSMKLLE EYADPESQAS
110 120 130 140 150
LQDLGLGVLK MPKEADEGGR ATCGSTRKGK RQHTSPQNPL LDCSLCGKVF
160 170 180 190 200
SSASSLSKHY LTHSQERKHV CKICSKAFKR QDHLTGHMLT HQKTKPFVCI
210 220 230 240 250
EQGCSKSYCD YRSLRRHYEV QHGLCILKEA PPEEEACGDS PHAHEGASQP
260 270 280 290 300
APAGLRSLVP PEARSPSSLL PNRDLLRCIV SSIVHQKIPS PGPAAAGPSD
310 320 330 340 350
GSEGRNTACP CAPSSGPSSC TPGGIPVAPG NLGIDVPEEP RPPRKEPAAA
360 370 380 390 400
MFTAVHSRAV ENGGTDLAES EPPLLPVPPT LEGWPEGGPL PACLPLFRAQ
410 420 430 440 450
TVPTSSQPAS HNFQWLRNLP GCPKNKGNNV FMVHKPPSVP SREGCESAPG
460 470 480 490 500
PSSTSPVGEP LPNSGPSLED ALPFPATLLK APGEASGDPR YVGGEDDSWV
510 520 530 540 550
SKKSKFDCDS FLRQNPGEPS LPDAQKPSGL PSDATPLFRQ LFLKSQESLV
560 570 580 590 600
SHEQMQVFQM IAKSQRIFSQ LPGPEGKQAA LKPLPGPWPQ QPPPPATPVD
610 620 630 640 650
SLHAGPGYPE PEGSPGRRKK TTPGFPREAS PGGTRRDTKG GPKVATAPLP
660 670 680 690 700
LTAASLDPPG NPDISSLAKQ LRSTKGTLDL GDIFSPGGPR QTQLGGEETL
710 720 730 740 750
GAPLPGKQAQ AENGPALGAG KGEKSQACTR GGGYRLFSGN PRSQRFSGFR
760 770 780 790 800
KEKVKMDMCC TASPSQVAMA SFSSAGPPAE PPQDSKSKLT IFNRIQGGNI
810 820 830 840 850
YRLPHPLKEE NVAGGCNQQN GGPADWAEPR STYVCKNCSQ MFYTEKGLSS
860 870 880 890 900
HMCFHSDQWP SPRGKQEQQV FGTEFCKPLR QVLRPEGDGQ SPPGAKKSLD
910 920 930 940 950
NTAAAPLAIP VSAPVAPATR PIGSAAKVGA GQYSHAILNS LLLLQGQEKD
960 970 980 990 1000
GEERDSKESS QHRKRKKRPQ PKSLSIPPAP SSLGELGLGG CHQSCLRSPV
1010 1020 1030 1040 1050
FLVDRLLKGL FQCSPYTPPP MLSPIREGSG LYFNTLCSTS VHAGPDKLIS
1060 1070 1080 1090 1100
NMLDQVDGSF GICMVKDDTK ISIEPHINIG SRFQAEIPEL QERSLAGMDE
1110 1120 1130 1140 1150
HVASLVWKPW GDVTTNPETQ DRVTELCNVA CSSVMPGGGT NLELALHCLH
1160 1170 1180 1190 1200
EAQGDVQIAL ETLLLRGPQK PQTHPLADYR YTGSDIWTPM EKRLFKKAFC
1210 1220 1230 1240 1250
AHKKDFYLIH KTIQTKTVAQ CVEYYYIWKK MIKFDCGRAP GLEKRVKREP
1260 1270 1280 1290 1300
DEADKTEAKV TCSPRERPSH RPTPEFKIKT KSYRRESILN SSPNAGPKRT
1310 1320 1330 1340 1350
PEPPGSVEGQ GVFPCRECER VFDKIKSRNA HMKRHRLQDH VEPIVRVKWP
1360 1370
VKPFQLKEEE EEEEEIGADI GPLQW
Length:1,375
Mass (Da):148,750
Last modified:October 31, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEED795022D87D740
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J9NYD8J9NYD8_CANLF
Zinc finger protein 541
ZNF541
1,378Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F1PNN3F1PNN3_CANLF
Zinc finger protein 541
ZNF541
1,360Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J9NXE8J9NXE8_CANLF
Zinc finger protein 541
ZNF541
1,045Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAEX03000832 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSCAFT00000044786; ENSCAFP00000038183; ENSCAFG00000004103

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03000832 Genomic DNA No translation available.

3D structure databases

SMRiJ9NY16
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000044786; ENSCAFP00000038183; ENSCAFG00000004103

Organism-specific databases

VGNCiVGNC:48757 ZNF541

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
KOG4167 Eukaryota
ENOG4110BKZ LUCA
GeneTreeiENSGT00940000160330

Gene expression databases

BgeeiENSCAFG00000004103 Expressed in 1 organ(s), highest expression level in prefrontal cortex

Family and domain databases

InterProiView protein in InterPro
IPR000949 ELM2_dom
IPR009057 Homeobox-like_sf
IPR001005 SANT/Myb
IPR017884 SANT_dom
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01448 ELM2, 1 hit
PF00096 zf-C2H2, 2 hits
SMARTiView protein in SMART
SM01189 ELM2, 1 hit
SM00717 SANT, 1 hit
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF46689 SSF46689, 1 hit
SSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS51156 ELM2, 1 hit
PS51293 SANT, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiJ9NY16_CANLF
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: J9NY16
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 31, 2012
Last sequence update: October 31, 2012
Last modified: June 5, 2019
This is version 34 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
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