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Protein

BMP and activin membrane-bound inhibitor homolog

Gene

BAMBI

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Negatively regulates TGF-beta signaling.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-CFA-2173788 Downregulation of TGF-beta receptor signaling

Names & Taxonomyi

Protein namesi
Recommended name:
BMP and activin membrane-bound inhibitor homologUniRule annotation
Gene namesi
Name:BAMBIImported
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)Imported
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 2

Organism-specific databases

VGNCiVGNC:38376 BAMBI

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei148 – 173HelicalSequence analysisAdd BLAST26

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_500382576921 – 260BMP and activin membrane-bound inhibitor homologSequence analysisAdd BLAST240

Proteomic databases

PaxDbiJ9NW61

Expressioni

Gene expression databases

BgeeiENSCAFG00000030262 Expressed in 3 organ(s), highest expression level in adult mammalian kidney

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000037405

Structurei

3D structure databases

ProteinModelPortaliJ9NW61
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili173 – 193Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the BAMBI family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IIU1 Eukaryota
ENOG4110R2C LUCA
GeneTreeiENSGT00390000014168
InParanoidiJ9NW61
KOiK10162
OMAiVTGHENC
OrthoDBiEOG091G0PAE
TreeFamiTF333466

Family and domain databases

InterProiView protein in InterPro
IPR009345 BAMBI
PANTHERiPTHR15505:SF1 PTHR15505:SF1, 1 hit
PfamiView protein in Pfam
PF06211 BAMBI, 1 hit
PIRSFiPIRSF037456 BAMBI, 1 hit

Sequencei

Sequence statusi: Complete.

J9NW61-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDRHSSYIFI WLQLELCAMA VLLSRGEIRC YCDAAHCVAT GYMCKSELSA
60 70 80 90 100
CFSRLLDPQN TNSPLTHGCL DSLANTADIC QAKQARNHSG TTMPTLECCH
110 120 130 140 150
EDMCNYRGLH DVLAPPKGEA SGQGNRYQHD GSRNLITKVQ ELTSSKELWF
160 170 180 190 200
RAAVIAVPIA GGLILVLLIM LALRMLRSEN KRLQDQRQQM LSRLHYSFHG
210 220 230 240 250
HHSKKGQVAK LDLECMVPVS GHENCCLTCD KMRQADLSNE KILSLVHWGM
260
YSGHGKLEFV
Length:260
Mass (Da):29,121
Last modified:October 31, 2012 - v1
Checksum:i429228FB1806B796
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03001230 Genomic DNA No translation available.
RefSeqiXP_544209.1, XM_544209.4

Genome annotation databases

EnsembliENSCAFT00000049991; ENSCAFP00000037405; ENSCAFG00000030262
GeneIDi487081
KEGGicfa:487081

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03001230 Genomic DNA No translation available.
RefSeqiXP_544209.1, XM_544209.4

3D structure databases

ProteinModelPortaliJ9NW61
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000037405

Proteomic databases

PaxDbiJ9NW61

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000049991; ENSCAFP00000037405; ENSCAFG00000030262
GeneIDi487081
KEGGicfa:487081

Organism-specific databases

CTDi25805
VGNCiVGNC:38376 BAMBI

Phylogenomic databases

eggNOGiENOG410IIU1 Eukaryota
ENOG4110R2C LUCA
GeneTreeiENSGT00390000014168
InParanoidiJ9NW61
KOiK10162
OMAiVTGHENC
OrthoDBiEOG091G0PAE
TreeFamiTF333466

Enzyme and pathway databases

ReactomeiR-CFA-2173788 Downregulation of TGF-beta receptor signaling

Gene expression databases

BgeeiENSCAFG00000030262 Expressed in 3 organ(s), highest expression level in adult mammalian kidney

Family and domain databases

InterProiView protein in InterPro
IPR009345 BAMBI
PANTHERiPTHR15505:SF1 PTHR15505:SF1, 1 hit
PfamiView protein in Pfam
PF06211 BAMBI, 1 hit
PIRSFiPIRSF037456 BAMBI, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiJ9NW61_CANLF
AccessioniPrimary (citable) accession number: J9NW61
Entry historyiIntegrated into UniProtKB/TrEMBL: October 31, 2012
Last sequence update: October 31, 2012
Last modified: September 12, 2018
This is version 31 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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