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Entry version 40 (05 Jun 2019)
Sequence version 1 (31 Oct 2012)
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Protein
Submitted name:

Bromodomain and PHD finger containing 3

Gene

BRPF3

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CFA-114608 Platelet degranulation
R-CFA-3214847 HATs acetylate histones
R-CFA-6804758 Regulation of TP53 Activity through Acetylation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Bromodomain and PHD finger containing 3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BRPF3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCanis lupus familiaris (Dog) (Canis familiaris)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9615 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002254 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:38534 BRPF3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
J9NVN9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSCAFG00000001386 Expressed in 3 organ(s), highest expression level in prefrontal cortex

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9612.ENSCAFP00000037231

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
J9NVN9

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini212 – 262PHD-typeInterPro annotationAdd BLAST51
Domaini266 – 387PHD-typeInterPro annotationAdd BLAST122
Domaini609 – 679BromoInterPro annotationAdd BLAST71
Domaini1080 – 1163PWWPInterPro annotationAdd BLAST84

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 27DisorderedSequence analysisAdd BLAST27
Regioni75 – 128DisorderedSequence analysisAdd BLAST54
Regioni386 – 451DisorderedSequence analysisAdd BLAST66
Regioni456 – 475DisorderedSequence analysisAdd BLAST20
Regioni782 – 804DisorderedSequence analysisAdd BLAST23
Regioni820 – 899DisorderedSequence analysisAdd BLAST80
Regioni913 – 1019DisorderedSequence analysisAdd BLAST107

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili568 – 595Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi75 – 90PolarSequence analysisAdd BLAST16
Compositional biasi107 – 123PolarSequence analysisAdd BLAST17
Compositional biasi413 – 435AcidicSequence analysisAdd BLAST23
Compositional biasi838 – 867Pro-richSequence analysisAdd BLAST30
Compositional biasi873 – 890PolyampholyteSequence analysisAdd BLAST18
Compositional biasi942 – 956PolyampholyteSequence analysisAdd BLAST15
Compositional biasi971 – 1004PolyampholyteSequence analysisAdd BLAST34
Compositional biasi1005 – 1019PolarSequence analysisAdd BLAST15

Keywords - Domaini

BromodomainPROSITE-ProRule annotation, Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0955 Eukaryota
COG5076 LUCA
COG5141 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155056

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
J9NVN9

Identification of Orthologs from Complete Genome Data

More...
OMAi
CMDDECH

TreeFam database of animal gene trees

More...
TreeFami
TF316118

Family and domain databases

Conserved Domains Database

More...
CDDi
cd05839 BR140_related, 1 hit
cd15703 ePHD_BRPF3, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.920.10, 1 hit
3.30.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035502 BR140-rel_PWWD
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR018359 Bromodomain_CS
IPR042005 BRPF3_ePHD
IPR019542 Enhancer_polycomb-like_N
IPR034732 EPHD
IPR000313 PWWP_dom
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00439 Bromodomain, 1 hit
PF10513 EPL1, 1 hit
PF00855 PWWP, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00503 BROMODOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00297 BROMO, 1 hit
SM00249 PHD, 2 hits
SM00293 PWWP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47370 SSF47370, 1 hit
SSF57903 SSF57903, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00633 BROMODOMAIN_1, 1 hit
PS50014 BROMODOMAIN_2, 1 hit
PS51805 EPHD, 1 hit
PS50812 PWWP, 1 hit
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

J9NVN9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRKPRRKSRQ NAEGRRSPSP YSLKCSPTRE TLTYAQAQRI VEVDIDGRLH
60 70 80 90 100
RISIYDPLKI ITEDELTAQD ITECNSNKEN SEQPQFPGKS KKPSSKGKKK
110 120 130 140 150
ESCSKHGSGT SFHLPQPSFR MVDSGSQPEA PPLPAAYYRY IEKPPEDLDA
160 170 180 190 200
EVEYDMDEED LAWLDMVNEK RRVDGHSVVS ADTFELLVDR LEKESYLESR
210 220 230 240 250
SSGAQQSLID EDAFCCVCLD DECHNSNVIL FCDICNLAVH QECYGVPYIP
260 270 280 290 300
EGQWLCRCCL QSPSRPVDCV LCPNKGGAFK QTSDGHWAHV VCAIWIPEVC
310 320 330 340 350
FANTVFLEPI EGIDNIPPAR WKLTCYICKQ KGLGAAIQCH KVNCYTAFHV
360 370 380 390 400
TCAQRAGLFM KIEPMRETSL NGTIFTVRKT AYCEAHSPPG AATTRRKGDS
410 420 430 440 450
PGSLSEAGDE EGLKEGCGEE EEKEEVEEEE EDEGQGGVGG PLKGLPKKNK
460 470 480 490 500
MALKQKIKKE PEEVSRDTPS TVPMVTVPQI PSYSQLEMTC SHRAVSVNNQ
510 520 530 540 550
FDVRFRNEYW LLKRQARNGV PLIRRLHSHL QSQRNAEQRE QDEKTSAVKE
560 570 580 590 600
ELKYWQKLRH DLERARLLIE LIRKREKLKR EQVKIQQAAM ELELMPFNVL
610 620 630 640 650
LRTTLDLLQE KDPAHIFAEP VNLSEVPDYL EFISKPMDFS TMRRKLESHL
660 670 680 690 700
YRTLEEFEED FNLIVTNCMK YNAKDTIFHR AAVRLRDLGG AILRHARRQA
710 720 730 740 750
ENIGYDPERG THLPESPKLE DFYRFSWEDV DNILIPENRA HLSPEVQLKE
760 770 780 790 800
LLEKLDLVSA MRSSGARTRR VRLLRREINA LRQKLAQPPP PPQPPSLNKT
810 820 830 840 850
VSNGELPAEA QGDVTVLEQA PQEEPEDDGD RDDSKLPPPP TLEPTGPAPS
860 870 880 890 900
LSEQDSPPDP PTLKPINDSK PPSRFLKPRK VEEDELLEKS PLQIGSEPLQ
910 920 930 940 950
RLLSDNGINR VSLMAPDVPA GTPLSGVGRR TSVLFKKAKN GVKLQRSPDR
960 970 980 990 1000
ALENGEDHGA VGSPASPASI EDEQHSRKRP RSRSCSESEG ERSPRQEEET
1010 1020 1030 1040 1050
GVTNGFGKHT ESGSDSECSL GLSGGLAFEA CSGLTPPKRS RGKPALSRVP
1060 1070 1080 1090 1100
FLEGVNGDSD YSSSGRSLLM PFEDRGDLEP LELVWAKCRG YPSYPALIID
1110 1120 1130 1140 1150
PKMPREGLLH NGVPIPVPPL DVLKLGEQKQ AEAGEKLFLV LFFDNKRTWQ
1160 1170 1180 1190 1200
WLPRDKVLPL GVEDTVDKLK MLEGRKTSIR KSVQVAYDRA MIHLSRVRGP

HSFVTSSYL
Length:1,209
Mass (Da):135,984
Last modified:October 31, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i401E23A87F89CB42
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E2RK73E2RK73_CANLF
Bromodomain and PHD finger containi...
BRPF3
1,207Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAEX03008281 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSCAFT00000047147; ENSCAFP00000037231; ENSCAFG00000001386

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03008281 Genomic DNA No translation available.

3D structure databases

SMRiJ9NVN9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9612.ENSCAFP00000037231

Proteomic databases

PaxDbiJ9NVN9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000047147; ENSCAFP00000037231; ENSCAFG00000001386

Organism-specific databases

VGNCiVGNC:38534 BRPF3

Phylogenomic databases

eggNOGiKOG0955 Eukaryota
COG5076 LUCA
COG5141 LUCA
GeneTreeiENSGT00940000155056
InParanoidiJ9NVN9
OMAiCMDDECH
TreeFamiTF316118

Enzyme and pathway databases

ReactomeiR-CFA-114608 Platelet degranulation
R-CFA-3214847 HATs acetylate histones
R-CFA-6804758 Regulation of TP53 Activity through Acetylation

Gene expression databases

BgeeiENSCAFG00000001386 Expressed in 3 organ(s), highest expression level in prefrontal cortex

Family and domain databases

CDDicd05839 BR140_related, 1 hit
cd15703 ePHD_BRPF3, 1 hit
Gene3Di1.20.920.10, 1 hit
3.30.40.10, 2 hits
InterProiView protein in InterPro
IPR035502 BR140-rel_PWWD
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR018359 Bromodomain_CS
IPR042005 BRPF3_ePHD
IPR019542 Enhancer_polycomb-like_N
IPR034732 EPHD
IPR000313 PWWP_dom
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF00439 Bromodomain, 1 hit
PF10513 EPL1, 1 hit
PF00855 PWWP, 1 hit
PRINTSiPR00503 BROMODOMAIN
SMARTiView protein in SMART
SM00297 BROMO, 1 hit
SM00249 PHD, 2 hits
SM00293 PWWP, 1 hit
SUPFAMiSSF47370 SSF47370, 1 hit
SSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS00633 BROMODOMAIN_1, 1 hit
PS50014 BROMODOMAIN_2, 1 hit
PS51805 EPHD, 1 hit
PS50812 PWWP, 1 hit
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiJ9NVN9_CANLF
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: J9NVN9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 31, 2012
Last sequence update: October 31, 2012
Last modified: June 5, 2019
This is version 40 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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