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Protein
Submitted name:

Dynein axonemal heavy chain 3

Gene

DNAH3

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Dynein axonemal heavy chain 3Imported
Gene namesi
Name:DNAH3Imported
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)Imported
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 6

Organism-specific databases

VGNCiVGNC:40015 DNAH3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSCAFG00000017844 Expressed in 1 organ(s), highest expression level in prefrontal cortex

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1377 – 1516AAAInterPro annotationAdd BLAST140
Domaini2021 – 2168AAAInterPro annotationAdd BLAST148

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili771 – 808Sequence analysisAdd BLAST38
Coiled coili1102 – 1122Sequence analysisAdd BLAST21
Coiled coili2676 – 2696Sequence analysisAdd BLAST21
Coiled coili2860 – 2925Sequence analysisAdd BLAST66
Coiled coili3176 – 3196Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3595 Eukaryota
COG5245 LUCA
GeneTreeiENSGT00910000144015
KOiK10408

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR035699 AAA_6
IPR011704 ATPase_dyneun-rel_AAA
IPR035706 DHC_D5
IPR026983 DHC_fam
IPR024743 Dynein_HC_stalk
IPR024317 Dynein_heavy_chain_D4_dom
IPR004273 Dynein_heavy_dom
IPR013602 Dynein_heavy_dom-2
IPR027417 P-loop_NTPase
PANTHERiPTHR10676 PTHR10676, 1 hit
PfamiView protein in Pfam
PF07728 AAA_5, 1 hit
PF12774 AAA_6, 1 hit
PF12780 AAA_8, 1 hit
PF12781 AAA_9, 1 hit
PF08393 DHC_N2, 1 hit
PF03028 Dynein_heavy, 1 hit
PF12777 MT, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 5 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

J9NT00-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDNMSDMGCS SQKITKSDSI HHMSHSQRQP ELPPFPASVN EQPSELYQTI
60 70 80 90 100
MSHSFYPPLM QRTSWTLAAP FKEQHHYRGP SDSIANNYSL MAQDLKLKDL
110 120 130 140 150
LKVYQPVTIN IPREKIFQGL PLANNCSSGP NKKKRKFSPR DKEDLTRTKL
160 170 180 190 200
ACSISVSSPI KKEVVISSTF PGSRPMSPEE QIDVMLQQEM EIEGKETQPS
210 220 230 240 250
ESDLERYYYY LTNGIRKDMI APEEEEVMHR ISKLISNTLL TSPLLEPLVI
260 270 280 290 300
LLVKEKENDY YSSLMKSIVD YILMDPTERE RLFIKNIPHV FPQRVIRAPV
310 320 330 340 350
PWHCVYRNAK KWNEEHLHTV NPMMLSLKEL WFAEFQDLRF VRTAELLGGK
360 370 380 390 400
LPLQPHEYWD VIQKHCMEAR QILLNKWIPT CAQLFVSKKE QWVHFAPKSD
410 420 430 440 450
YDSSRNIEEY FASIAAFMSL QLRDLVIKSL EDLMSFFMIH KDGNDFEEPY
460 470 480 490 500
QEMEFFLPQL ITIKLEVIEP IIVFNPSFDD CWELIHNSFL EIIKNSREIP
510 520 530 540 550
KVESVLFPEL KGYNLILGTV NTEEKLVSDF VDQTFEVFQK NQVGPRKYLN
560 570 580 590 600
VYKKYDDLLD NMAEQNITAF LKENHEIEDF VTRISSIKKR RNEIASMHIT
610 620 630 640 650
VPLAMFCLDT MTLNYDLCER AQNLKDRLIQ FQVEVNRDTN TSICNQYNII
660 670 680 690 700
ADKVSEIPAN TEELVFLIEF LKKSSNVTVF KLRRQLRDAI ERLEFLMDYA
710 720 730 740 750
DLPQEDIKLN STLFLWPDQI EDIFENSRNL LLSKRDQAEM DLIKRCSEFG
760 770 780 790 800
SKLEGYNKEL EGFRKREVMT TEEMKNNVEK LHELSKNLDQ ALVEFELINK
810 820 830 840 850
EEELLEKEKS TFPLLQALMI NKVPYEQLWL TAYEFSIKSE EWMNGPLFLL
860 870 880 890 900
NAEEIAEEIG NMWRTIYKLT KTLADVPAPR RLAENVKVKI DKFKQHIPIL
910 920 930 940 950
SISCNPGMKD RHWQQISEIA GYEIKPTETT CLSNMLEYGF SKFIDKLEPI
960 970 980 990 1000
GAAASKEYSL EKNLEKMKSD WVNMTFNFVK YRDTDTNILC AVDDIQLLLD
1010 1020 1030 1040 1050
DHVIKTQTMC GSPFIKPIEA ECRKWEEKLV RVQEILDAWL KCQATWLYLE
1060 1070 1080 1090 1100
PIFSSEDIIA QMAEEGRKFA TVDSYWKSLM SQAVKDTRVL VAADQPRMAE
1110 1120 1130 1140 1150
RLQEANLLLE DIQKGLNDYL EKKRLFFPRF FFLSNDELLE ILSETKDPLR
1160 1170 1180 1190 1200
VQPHLKKCFE GIAKLEFTDN LEITGMISSE KETVPFKQII YPTQAKGMVE
1210 1220 1230 1240 1250
KWLQQVEQMM LASMREVIRL GIEAYVQVPR NQWVLQWPGQ VVICVSSIFW
1260 1270 1280 1290 1300
TKEVSQALVE KTLPDFLKKS NDQIAQIVQL VRGKLSSGAR LTLGALTVID
1310 1320 1330 1340 1350
VHARDVVAKL SEDNICDLND FQWISQLRYY WNSENVHVQM ITTEALYGYE
1360 1370 1380 1390 1400
YLGNSPRLVI TPLTDRCYRT LMGALKLNLG GAPEGPAGTG KTETTKDLAK
1410 1420 1430 1440 1450
ALAKQCVVFN CSDGLDYKAM GKFFKGLAQA GAWACFDEFN RIEVEVLSVV
1460 1470 1480 1490 1500
AQQILSIQQA IIRKLKTFIF EGTELSLNPT CAVFITMNPG YAGRAELPDN
1510 1520 1530 1540 1550
LKALFRTVAM MVPDYALIGE ISLYSMGFLD SRSLAQKIVA TYRLCSEQLS
1560 1570 1580 1590 1600
SQHHYDYGMR AVKSVLTAAG NLKLKYPEEN ESVLLLRALL DVNLAKFLAQ
1610 1620 1630 1640 1650
DVPLFQGIIS DLFPGVVLPK PDYEVFMEVL NENIKKMKLQ PVPWFIAKII
1660 1670 1680 1690 1700
QIYEMMLVRH GYMIVGDPMG GKTCAYKVLA AALGDLYEAN QMDEFAVEYR
1710 1720 1730 1740 1750
IINPKAITMG QLYGCFDPVS HEWTDGILAN AFREQASSMS DERKWIIFDG
1760 1770 1780 1790 1800
PVDAVWIENM NTVLDDNKKL CLMSGEIIQM SPKMSLIFEP ADLEQASPAT
1810 1820 1830 1840 1850
VSRCGMIYME PHQLGWKPLK DSYMDTLPTS LTEEHKELVN DMFMWLVQPC
1860 1870 1880 1890 1900
LEFIRLQCKF VVQTSPVHLA FSMMRLYSSL LDEIREIDEE SELYEGLTSQ
1910 1920 1930 1940 1950
QIFLWLQGLF LFALVWTVAG TINAESRKKF DLFFRNLIMG MDDKNPRPKS
1960 1970 1980 1990 2000
VKLTKNNIFP DRGSIYDFYF LKQGGGHWYT WTEYITKEEE NIPANAKVSE
2010 2020 2030 2040 2050
LIIPTMETAR QSFFLKTYLD HEIPVLFVGP TGTGKSVITN NFLLRLPKNT
2060 2070 2080 2090 2100
YLPNFINFSA RTSANQTQDI IMSKLDRRRK GLFGPPIGKK AVVFVDDLNM
2110 2120 2130 2140 2150
PAKEVYGAQP PIELLRQWID HGCWFDKKDT NKLDIVDVLL VTAMGPPGGG
2160 2170 2180 2190 2200
RNDITGRFTR HLNIVSINAF EDDILTKIFS SIADWHFGKG FDVIFLRYGK
2210 2220 2230 2240 2250
MLVQATMTIY KAAVENFLPT PSKSHYVFNL RDFSRVIQGV LLCPHTHLQD
2260 2270 2280 2290 2300
VEKFIRLWIH EVYRVFYDRL IDHEDRQVFF NMVKETTSSC FKQTMEKVLI
2310 2320 2330 2340 2350
HLSPTGKIVD DNIRSLFFGD FFKPESDPKI YDEITDLKQL TVVMEYYLEE
2360 2370 2380 2390 2400
FNNISKAPMS LVMFRFAIEH ISRICRVLKQ DKGHLLLVGI GGSGRQSASK
2410 2420 2430 2440 2450
LSTFMNSYEL YQIEITKNYS SYDWREDLKK IMLQVGVATK RTVFLFTDNQ
2460 2470 2480 2490 2500
IKDESFVEDI NMLLNTGDVP NIFPADEKAD LVEKMQMAVR TEGEKIEVTP
2510 2520 2530 2540 2550
LSMYNFFIDR VKKNLHIVLA MSPIGDAFRN RLRMFPSLIN CCTIDWFQSW
2560 2570 2580 2590 2600
PTDALELVAN KFLEDVELDD NIRIEVISMC KYFQESVKDM SLDYYNTLRR
2610 2620 2630 2640 2650
HNYVTPTSYL ELILTFKTLL NTKRQEVDMM RNRYLTGLQK LEFASSQVAV
2660 2670 2680 2690 2700
MQVELTALQP QLIQTSEETA RMMVKIEEET READAKKLLV QADEKESNAA
2710 2720 2730 2740 2750
AAIAQGIKTE CEGDLAEAMP ALEAALAALD TLNPADISLV KSMQNPPGPV
2760 2770 2780 2790 2800
KLVMESICVM KGLKPERKPD PSGSGKMIED YWGVSRKILG DLKFLESLKT
2810 2820 2830 2840 2850
YDKDNIAPVI MKRIRERFID HPDFQPAVIK NVSSACEGLC KWVRAMEVYD
2860 2870 2880 2890 2900
RVAKVVAPKR ERLREAEGKL DIQMQKLNQK RAELKLVEDR LQALNDDFEE
2910 2920 2930 2940 2950
MNTKKKTLEE NIEICSQKLI RAEKLISGLG GEKDRWTEAA RQLGIRYTNL
2960 2970 2980 2990 3000
TGDVLLSSGT VAYLGAFTVD YRARCQKQWL AQCKDKVIPS SSDFSLSNTL
3010 3020 3030 3040 3050
GDPVKIRAWQ IAGLPIDSFS IDNGIIVTNS RRWALMIDPQ GQANKWIKNM
3060 3070 3080 3090 3100
EKANKLSIIK FSDANYVRTL ENALQFGTPV LLENVGEELD AFIEPILLKS
3110 3120 3130 3140 3150
TFRQQGVEYM RLGENIIEYS RDFKLYITTR LRNPHYLPEV AVKVCLLNFM
3160 3170 3180 3190 3200
ITPFGLQDQL LGIVAAKEKP ELEEKKNELI VESARNKKQL KEIEDKILEV
3210 3220 3230 3240 3250
LSLSEGNILE DETAIKVLSS SKILSEEISE KQEIASVTET QIDETRMGYK
3260 3270 3280 3290 3300
PVAVHSATIF FCISDLANIE PMYQYSLTWF INLYVHSLAH SSKSEELDLR
3310 3320 3330 3340 3350
IEYIIEHFTL SIYNNVCRSL FEKDKLLFSL LLTIGIMKEK KQINEEVWYF
3360 3370 3380 3390 3400
LLTGGVALDN PFPNPAPEWL SEKAWAEVVR ASALPKLKGL MEHLEQNSEE
3410 3420 3430 3440 3450
WKLIYDSTWP HEEKFPGSWK FLKGLERMVV LRCLRPDKII PAIRDFIAEH
3460 3470 3480 3490 3500
MGDVFIEAPT FDLQGSYNDS SCCVPLIFVL SPGADPMAGL LKFADDLGMG
3510 3520 3530 3540 3550
GAKTQTISLG QGQGSIAAKM INAAITDGTW VVLQNCHLAT SWMPTLEKIC
3560 3570 3580 3590 3600
EEVIIPESTN ISFRLWLTSY PSEKFPVSIL QNGIKMTNEP PKGLRANLLR
3610 3620 3630 3640 3650
SFLNDPISDP VFFQSCTKAV MWQKLLFGLC FFHAIVQERR NFGPLGWNIP
3660 3670 3680 3690 3700
YEFNESDLRI SMQQVQMFLN DYKEVPFDAL TYLTGECNYG GRVTDDKDRR
3710 3720 3730 3740 3750
LLLSLLSTVY CKEIEQDHYY IAPGDTYYIP PHGSYQSYID YLRNLPITAH
3760 3770 3780 3790 3800
PEVFGLHENA DITKDNQETN QLFQGVLLTL PRQSGGSGKS PQEVVQELAQ
3810 3820 3830 3840 3850
DILSKLPNDF DLEMVVNLYP VVYEESMNTV LRQELIRFNR LTKVVRGSLI
3860 3870 3880 3890 3900
NLGRAIKGQV LMSSELEDVF SSMIVGKVPA MWMAKSYPSL KPLGGYVADL
3910 3920 3930 3940 3950
LARLAFFQEW IDNGPPVVFW ISGFYFTQSF LTGISQNYAR KHTIPIDHIG
3960 3970 3980 3990 4000
FEFEVTTQET VMESSPEDGA YIKGLFLEGA RWDRKTMQIG ESFPKILYDP
4010 4020 4030 4040 4050
LPIIWLKPGE SAMFLHQNIY VCPVYKTSAR RGILSTTGHS TNYVLSIELP
4060 4070
TDRPQKHWIN RGVASLCQLD N
Length:4,071
Mass (Da):467,314
Last modified:October 31, 2012 - v1
Checksum:i5FE4147AFA7020EB
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J9NWH9J9NWH9_CANLF
Dynein axonemal heavy chain 3
DNAH3
4,081Annotation score:
F1PBB5F1PBB5_CANLF
Dynein axonemal heavy chain 3
DNAH3
4,075Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03004469 Genomic DNA No translation available.
AAEX03004470 Genomic DNA No translation available.
AAEX03004471 Genomic DNA No translation available.
RefSeqiXP_005621521.2, XM_005621464.2

Genome annotation databases

EnsembliENSCAFT00000043892; ENSCAFP00000041852; ENSCAFG00000017844
GeneIDi489981
KEGGicfa:489981

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03004469 Genomic DNA No translation available.
AAEX03004470 Genomic DNA No translation available.
AAEX03004471 Genomic DNA No translation available.
RefSeqiXP_005621521.2, XM_005621464.2

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSCAFT00000043892; ENSCAFP00000041852; ENSCAFG00000017844
GeneIDi489981
KEGGicfa:489981

Organism-specific databases

CTDi55567
VGNCiVGNC:40015 DNAH3

Phylogenomic databases

eggNOGiKOG3595 Eukaryota
COG5245 LUCA
GeneTreeiENSGT00910000144015
KOiK10408

Gene expression databases

BgeeiENSCAFG00000017844 Expressed in 1 organ(s), highest expression level in prefrontal cortex

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR035699 AAA_6
IPR011704 ATPase_dyneun-rel_AAA
IPR035706 DHC_D5
IPR026983 DHC_fam
IPR024743 Dynein_HC_stalk
IPR024317 Dynein_heavy_chain_D4_dom
IPR004273 Dynein_heavy_dom
IPR013602 Dynein_heavy_dom-2
IPR027417 P-loop_NTPase
PANTHERiPTHR10676 PTHR10676, 1 hit
PfamiView protein in Pfam
PF07728 AAA_5, 1 hit
PF12774 AAA_6, 1 hit
PF12780 AAA_8, 1 hit
PF12781 AAA_9, 1 hit
PF08393 DHC_N2, 1 hit
PF03028 Dynein_heavy, 1 hit
PF12777 MT, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 5 hits
ProtoNetiSearch...

Entry informationi

Entry nameiJ9NT00_CANLF
AccessioniPrimary (citable) accession number: J9NT00
Entry historyiIntegrated into UniProtKB/TrEMBL: October 31, 2012
Last sequence update: October 31, 2012
Last modified: September 12, 2018
This is version 34 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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