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UniProtKB - J9NSF9 (J9NSF9_CANLF)

Entry version 70 (07 Apr 2021)
Sequence version 2 (11 Dec 2019)
Previous versions | rss
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Protein

Activation peptide fragment 1

Gene

F2

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.ARBA annotation EC:3.4.21.5

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Serine proteaseUniRule annotation
Biological processAcute phaseARBA annotation, Blood coagulationARBA annotation, Hemostasis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-CFA-140837, Intrinsic Pathway of Fibrin Clot Formation
R-CFA-140875, Common Pathway of Fibrin Clot Formation
R-CFA-159740, Gamma-carboxylation of protein precursors
R-CFA-159763, Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
R-CFA-159782, Removal of aminoterminal propeptides from gamma-carboxylated proteins
R-CFA-375276, Peptide ligand-binding receptors
R-CFA-416476, G alpha (q) signalling events
R-CFA-456926, Thrombin signalling through proteinase activated receptors (PARs)
R-CFA-977606, Regulation of Complement cascade

Protein family/group databases

MEROPS protease database

More...MEROPSi		S01.217

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Activation peptide fragment 1ARBA annotation (EC:3.4.21.5ARBA annotation)
Alternative name(s):
Activation peptide fragment 2ARBA annotation
Coagulation factor IIARBA annotation
ProthrombinARBA annotation
Thrombin heavy chainARBA annotation
Thrombin light chainARBA annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:F2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCanis lupus familiaris (Dog) (Canis familiaris)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9615 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002254 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...VGNCi		VGNC:40547, F2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_502385139223 – 670Activation peptide fragment 1Sequence analysisAdd BLAST648

Keywords - PTMi

Disulfide bondARBA annotation, ZymogenARBA annotation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		J9NSF9

PRoteomics IDEntifications database

More...PRIDEi		J9NSF9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSCAFG00000009122, Expressed in liver and 33 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		9612.ENSCAFP00000013434

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini42 – 88GlaInterPro annotationAdd BLAST47
Domaini106 – 185KringleInterPro annotationAdd BLAST80
Domaini212 – 291KringleInterPro annotationAdd BLAST80
Domaini363 – 666Peptidase S1InterPro annotationAdd BLAST304

Keywords - Domaini

KringlePROSITE-ProRule annotationARBA annotation, SignalSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QTSX, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154234

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_006842_19_4_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		J9NSF9

Identification of Orthologs from Complete Genome Data

More...OMAi		VMIFRKS

Database of Orthologous Groups

More...OrthoDBi		1314811at2759

Family and domain databases

Conserved Domains Database

More...CDDi		cd00108, KR, 2 hits
cd00190, Tryp_SPc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.40.10.10, 3 hits
2.40.20.10, 2 hits
4.10.140.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR035972, GLA-like_dom_SF
IPR000294, GLA_domain
IPR000001, Kringle
IPR013806, Kringle-like
IPR018056, Kringle_CS
IPR038178, Kringle_sf
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR001314, Peptidase_S1A
IPR003966, Prothrombin/thrombin
IPR018992, Thrombin_light_chain
IPR037111, Thrombin_light_chain_sf
IPR001254, Trypsin_dom
IPR018114, TRYPSIN_HIS
IPR033116, TRYPSIN_SER

The PANTHER Classification System

More...PANTHERi		PTHR24254:SF10, PTHR24254:SF10, 2 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00594, Gla, 1 hit
PF00051, Kringle, 2 hits
PF09396, Thrombin_light, 1 hit
PF00089, Trypsin, 2 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00722, CHYMOTRYPSIN
PR00001, GLABLOOD
PR01505, PROTHROMBIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00069, GLA, 1 hit
SM00130, KR, 2 hits
SM00020, Tryp_SPc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50494, SSF50494, 1 hit
SSF57440, SSF57440, 2 hits
SSF57630, SSF57630, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00011, GLA_1, 1 hit
PS50998, GLA_2, 1 hit
PS00021, KRINGLE_1, 2 hits
PS50070, KRINGLE_2, 2 hits
PS50240, TRYPSIN_DOM, 1 hit
PS00134, TRYPSIN_HIS, 1 hit
PS00135, TRYPSIN_SER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

J9NSF9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAHIRGLWLP GCLVILFSLA HSQHVFLDPQ QALSLLHRVR RANSGFLEEL 
        60         70         80         90        100
RKGNLERECV EEQCNYEEAF EALESSTATD VFWSKYTACE PVRKPREKLV 
       110        120        130        140        150
ECLEGSCAEG LGMNYRGNVS FTRSGIECQL WRSRYPHKPE INSTTHPGAD 
       160        170        180        190        200
LQENFCRNPD GSTTGPWCYT IDPTVRREEC SISLCGQQGG VTVPLTPRSG 
       210        220        230        240        250
GPTVNLSPPS EHCIPERGRY YQGRLAVTTH GSPCLAWASR QAKALSKDQD 
       260        270        280        290        300
FNPAVPLVEN FCRNPDGDEE GAWCYVSEEP GGFEYCDLDY CEEPVEEVGD 
       310        320        330        340        350
GLAEDQDTAI EGRTTAEEFQ PFFNEKTFGA GEADCGLRPL FEKRSVKDKT 
       360        370        380        390        400
EGELLESYID GRIVEGWDAE IGLAPWQVML FRKSPQELLC GASLISDRWV 
       410        420        430        440        450
LTAAHCLLYP PWDKNFTEND LLVRIGKHSR TSGKLSSLCC QGHLAMSQLR 
       460        470        480        490        500
LGAWDRETQT LQRVKSWPTP SFSPAPRTWY RYERSIEKIS MLEKIYIHPR 
       510        520        530        540        550
YNWRENLDRD IALLKLKKPV NFSNYIHPVC LPDRDTATRL LQAGYKGRVT 
       560        570        580        590        600
GWGNLRETWT SSIGEVQPRV LQVVNLPIVD RQVCKASTRI RITDNMFCAG 
       610        620        630        640        650
YKPNEGKRGD ACEGDSGGPF VMKSPFNNRW YQMGIVSWGE GCDRDGKYGF 
       660        670
YTHVFRLKKW IQKVIEKSGG
Length:670
Mass (Da):75,850
Last modified:December 11, 2019 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC87963A44CAD8CA8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E2RRM2E2RRM2_CANLF
Prothrombin
F2
621Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AAEX03011494 Genomic DNA No translation available.
AAEX03011495 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSCAFT00000045274; ENSCAFP00000037638; ENSCAFG00000009122

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03011494 Genomic DNA No translation available.
AAEX03011495 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi9612.ENSCAFP00000013434

Protein family/group databases

MEROPSiS01.217

Proteomic databases

PaxDbiJ9NSF9
PRIDEiJ9NSF9

Genome annotation databases

EnsembliENSCAFT00000045274; ENSCAFP00000037638; ENSCAFG00000009122

Organism-specific databases

VGNCiVGNC:40547, F2

Phylogenomic databases

eggNOGiENOG502QTSX, Eukaryota
GeneTreeiENSGT00940000154234
HOGENOMiCLU_006842_19_4_1
InParanoidiJ9NSF9
OMAiVMIFRKS
OrthoDBi1314811at2759

Enzyme and pathway databases

ReactomeiR-CFA-140837, Intrinsic Pathway of Fibrin Clot Formation
R-CFA-140875, Common Pathway of Fibrin Clot Formation
R-CFA-159740, Gamma-carboxylation of protein precursors
R-CFA-159763, Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
R-CFA-159782, Removal of aminoterminal propeptides from gamma-carboxylated proteins
R-CFA-375276, Peptide ligand-binding receptors
R-CFA-416476, G alpha (q) signalling events
R-CFA-456926, Thrombin signalling through proteinase activated receptors (PARs)
R-CFA-977606, Regulation of Complement cascade

Gene expression databases

BgeeiENSCAFG00000009122, Expressed in liver and 33 other tissues

Family and domain databases

CDDicd00108, KR, 2 hits
cd00190, Tryp_SPc, 1 hit
Gene3Di2.40.10.10, 3 hits
2.40.20.10, 2 hits
4.10.140.10, 1 hit
InterProiView protein in InterPro
IPR035972, GLA-like_dom_SF
IPR000294, GLA_domain
IPR000001, Kringle
IPR013806, Kringle-like
IPR018056, Kringle_CS
IPR038178, Kringle_sf
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR001314, Peptidase_S1A
IPR003966, Prothrombin/thrombin
IPR018992, Thrombin_light_chain
IPR037111, Thrombin_light_chain_sf
IPR001254, Trypsin_dom
IPR018114, TRYPSIN_HIS
IPR033116, TRYPSIN_SER
PANTHERiPTHR24254:SF10, PTHR24254:SF10, 2 hits
PfamiView protein in Pfam
PF00594, Gla, 1 hit
PF00051, Kringle, 2 hits
PF09396, Thrombin_light, 1 hit
PF00089, Trypsin, 2 hits
PRINTSiPR00722, CHYMOTRYPSIN
PR00001, GLABLOOD
PR01505, PROTHROMBIN
SMARTiView protein in SMART
SM00069, GLA, 1 hit
SM00130, KR, 2 hits
SM00020, Tryp_SPc, 1 hit
SUPFAMiSSF50494, SSF50494, 1 hit
SSF57440, SSF57440, 2 hits
SSF57630, SSF57630, 1 hit
PROSITEiView protein in PROSITE
PS00011, GLA_1, 1 hit
PS50998, GLA_2, 1 hit
PS00021, KRINGLE_1, 2 hits
PS50070, KRINGLE_2, 2 hits
PS50240, TRYPSIN_DOM, 1 hit
PS00134, TRYPSIN_HIS, 1 hit
PS00135, TRYPSIN_SER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiJ9NSF9_CANLF
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: J9NSF9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 31, 2012
Last sequence update: December 11, 2019
Last modified: April 7, 2021
This is version 70 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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