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Entry version 35 (12 Aug 2020)
Sequence version 2 (14 May 2014)
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Protein

Reverse transcriptase domain-containing protein

Gene
N/A
Organism
Acyrthosiphon pisum (Pea aphid)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Reverse transcriptase domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAcyrthosiphon pisum (Pea aphid)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7029 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraParaneopteraHemipteraSternorrhynchaAphidomorphaAphidoideaAphididaeMacrosiphiniAcyrthosiphon
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007819 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini458 – 731Reverse transcriptaseInterPro annotationAdd BLAST274

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili323 – 343Sequence analysisAdd BLAST21
Coiled coili1014 – 1034Sequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1075, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_242900_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
J9LM37

Database of Orthologous Groups

More...
OrthoDBi
1233632at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.60.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR043502, DNA/RNA_pol_sf
IPR036691, Endo/exonu/phosph_ase_sf
IPR005135, Endo/exonuclease/phosphatase
IPR000477, RT_dom
IPR021896, Transposase_37

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14529, Exo_endo_phos_2, 1 hit
PF00078, RVT_1, 1 hit
PF12017, Tnp_P_element, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56219, SSF56219, 1 hit
SSF56672, SSF56672, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50878, RT_POL, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

J9LM37-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MISFLQINLH RSSTAQSLLQ QTAAATGAQV LLVSEQNWSP ARDDRWAVSD
60 70 80 90 100
DRSCAVALTA TADFAPESSG SGRGFAWIQT RGLRMYSCYT SRNDTEANFQ
110 120 130 140 150
SFLLDIQHSI RSADTQLAIV IGGDFNSWSQ EWGSARNDER GDRLSDLAAS
160 170 180 190 200
LDLLVANAGT TPTYCRANAE SVIDVTFHRL TAPGAIRDWR VLEDVYSASD
210 220 230 240 250
HRYVAFTLDR SIEGEDIGGP VSRGWSYRQL NPDALAAYLA STAEPIVRGE
260 270 280 290 300
TTATEAANSL IEYLEGACDS CMPPRTPHRT GRKEVHWWST DLTTLRNTTI
310 320 330 340 350
KLRRAHHRSS RRRDPQGTVD AHREAYTTKR KELRNAIRDA QSKSWAELCR
360 370 380 390 400
AVDDDPWGLP YKVVTKKIGR SRPGVEARGR EAAIADHLFP DPPPTVWAHE
410 420 430 440 450
PLLTDDQQQG HEFTMVEILT ACRRLPAGKA TGPDGIPNEV LLHVARLRPW
460 470 480 490 500
VLQKTFNACL VRREFPARWK TARLVLLHKG SGKPIDEPSS FRPLCMLDSA
510 520 530 540 550
GKLLERLVLG RLNQHLDDSG QRSENQYGFR NGRSTVDAIE RVLQAAHGAA
560 570 580 590 600
TGAVQHRDIC VAVSLDVKNA FNTAPWRRID AALRASQTPS YLNNIIRSYL
610 620 630 640 650
DGRKLLVGQS LLSRNVTCGV PQGSVLGPAL WNAFYDRLLD TEMPSGVQLV
660 670 680 690 700
AFADDLCVLG IARKGEAAST LLNPVLEKVS DWMTSNGLKL APAKTEAVVL
710 720 730 740 750
TRKNVYDEPE LFVEGHAIPI KPSMRYLGVE LDTRLSFTKH VQQASLKASQ
760 770 780 790 800
SALAIGRLMP NIGGPSQSKR ALLGSVANSK MLYASPVWAA RGTKTAKNRL
810 820 830 840 850
AMARAQRTVA LRTIRAYCTV SAETSSILAS MLPADLLATE RARIRTRLDD
860 870 880 890 900
QADETPTNTL KNQERAISIA AWQARWDRSK NARWTRRLIP NVSRWLAKPP
910 920 930 940 950
LNLTYRLTQA LSGHGCFKSS LYRFTRSEDS YCVYCVDPDD TAEHTLFVCP
960 970 980 990 1000
RWEDDRTRLS EILRRPPTAA DVEEILCGPS TDAMPDDPAA RLRLMEQVKI
1010 1020 1030 1040 1050
NRQELITMIE SIMSTKEQDE REDQADDLAR LNRKMLIYYI KMLLKYKVFT
1060 1070 1080 1090 1100
IMLASSNRKN PKGNRYTEDW IMLCMLLHIR SPAGYAFLKN NQLLPLPCVR
1110 1120 1130 1140 1150
TIRKYLAQIP TTCGFDKCFF ELFKKHLSAK NNFQKHGLLI FDEISLRESI
1160 1170 1180 1190 1200
SVNAKTLSYT GLIDFGKDNE ELDNLPKAID INSKATHGLV FMFQPLADSY
1210 1220 1230 1240 1250
TQPIGVFASR GPVNGLTLVK LIIKAVLLLG AYVHGFVSDG AQTNRRVWTE
1260 1270 1280 1290 1300
LGISGKLNST SFYTEHFVDE NRKFFAFSDT PHLIKCVRNR LYNNKKLKIN
1310 1320 1330 1340 1350
PNENYVKWEH FVTLHEQDKQ NCSSQLRVCP KITTNHISLN NSCLKIRVSL
1360 1370 1380 1390 1400
ATQILTKSVA DGLSFYSKHK IPEMQNCDAT INFCLVFNDM FDALNAKIPC
1410 1420 1430 1440 1450
QGVHLNSKNY EILQRSLKWL DSWESNVISG NISESEFLTK STAEGLRVTI
1460 1470 1480 1490 1500
SSCIELVNYM KEKYDFDYIL TGKINQDALE DGFWSKRPSL HTYSFASVQV
1510 1520 1530 1540 1550
AYSICHFKNH PNIQNIYTSS EPSALEKLQK KLDGFVNQGE WEFSDIVEHD
1560 1570 1580 1590 1600
YSIVPIVDCL KYYVAGYLSH QITKRSSCLQ CKSAFTVISN FKPEADLTNI
1610 1620 1630
KSRGWLKHPN PYLYSLISAI EDEFMKHVNS NSSKSKGKC
Length:1,639
Mass (Da):184,247
Last modified:May 14, 2014 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i995491857797C220
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
ABLF02014650 Genomic DNA No translation available.

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
ACYPI44044-RA; ACYPI44044-PA; ACYPI44044

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABLF02014650 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblMetazoaiACYPI44044-RA; ACYPI44044-PA; ACYPI44044

Phylogenomic databases

eggNOGiKOG1075, Eukaryota
HOGENOMiCLU_242900_0_0_1
InParanoidiJ9LM37
OrthoDBi1233632at2759

Family and domain databases

Gene3Di3.60.10.10, 1 hit
InterProiView protein in InterPro
IPR043502, DNA/RNA_pol_sf
IPR036691, Endo/exonu/phosph_ase_sf
IPR005135, Endo/exonuclease/phosphatase
IPR000477, RT_dom
IPR021896, Transposase_37
PfamiView protein in Pfam
PF14529, Exo_endo_phos_2, 1 hit
PF00078, RVT_1, 1 hit
PF12017, Tnp_P_element, 1 hit
SUPFAMiSSF56219, SSF56219, 1 hit
SSF56672, SSF56672, 1 hit
PROSITEiView protein in PROSITE
PS50878, RT_POL, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiJ9LM37_ACYPI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: J9LM37
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 31, 2012
Last sequence update: May 14, 2014
Last modified: August 12, 2020
This is version 35 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported, Transposable elementARBA annotation
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