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Entry version 36 (12 Aug 2020)
Sequence version 2 (14 May 2014)
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Protein

Reverse transcriptase domain-containing protein

Gene
N/A
Organism
Acyrthosiphon pisum (Pea aphid)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Reverse transcriptase domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAcyrthosiphon pisum (Pea aphid)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7029 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraParaneopteraHemipteraSternorrhynchaAphidomorphaAphidoideaAphididaeMacrosiphiniAcyrthosiphon
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007819 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 17Sequence analysisAdd BLAST17
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500382661718 – 1310Reverse transcriptase domain-containing proteinSequence analysisAdd BLAST1293

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini892 – 1158Reverse transcriptaseInterPro annotationAdd BLAST267

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni25 – 45DisorderedSequence analysisAdd BLAST21
Regioni87 – 181DisorderedSequence analysisAdd BLAST95
Regioni414 – 448DisorderedSequence analysisAdd BLAST35
Regioni1288 – 1310DisorderedSequence analysisAdd BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi30 – 45PolarSequence analysisAdd BLAST16
Compositional biasi135 – 162PolarSequence analysisAdd BLAST28

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1075, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000680_38_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
J9LC21

Database of Orthologous Groups

More...
OrthoDBi
1587309at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.60.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR043502, DNA/RNA_pol_sf
IPR036691, Endo/exonu/phosph_ase_sf
IPR005135, Endo/exonuclease/phosphatase
IPR000477, RT_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14529, Exo_endo_phos_2, 1 hit
PF00078, RVT_1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56219, SSF56219, 1 hit
SSF56672, SSF56672, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50878, RT_POL, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

J9LC21-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPIPFCVIFL VTDWVLHLDK PKCRNSAAPS DDVLPSTTTS PDSGESIPMA
60 70 80 90 100
TTMLLCFALQ WEPRKNPSCV CKYVGYNIAV NYSEQRNTMG GRRAKRKRTP
110 120 130 140 150
PASSSKKTRG DTYSPPPLHA ARRQRAAPPS PESIDEQLSG ESYFSDSDST
160 170 180 190 200
IASSTLSHHS PSPPPTSNHP NQNNSSGLQK DDANPIVAKT TIRIPPIFVA
210 220 230 240 250
KSFDWRKVAP IIFRNAIVSP VNISAQATSD GSIIIKTRAI EHFRLIQKTL
260 270 280 290 300
LDQNIQFKTS KLPEERTLKV VLRGIPTDIS TDELKSELEL LKFDVKLIKR
310 320 330 340 350
FGPVNKPMPI CLVILGNTQN SKLIYEVSDL FFIKVTVESY KKTGPSQCFA
360 370 380 390 400
CQRIGHGSSN CTHPLRCVKC SGEHKASLCP KTTDQEPRCC NCDGNHTANY
410 420 430 440 450
RGCPYLAQAA CTKPIKIPQP NPPSPATQPD QPQKADTTKK DYASATKPKN
460 470 480 490 500
TFNSEQVIEL LTDLLSVLST PDDPKSMNDL PLIRGSPAHG GTAILVHRKI
510 520 530 540 550
VHQSININTK FQSTSILIKI SNKSTLISSV YKPPSSTLIT SDIDLLINSA
560 570 580 590 600
DNFIIAGDLN SKHPLWNSRR TNAAGLILYN HLLQNDYSII APDTPTHFPS
610 620 630 640 650
SKKYRPDVLD IAIVRTHLLV HITNLNELSS DHNPILLEFS DSPITVSPPT
660 670 680 690 700
PNTQINWDKF YHTLSAEKPN MALLTNTKQN IENSIQAFTN SIHSALDNSS
710 720 730 740 750
YLRNKNSRRP VIPAEIQQEI NAKNRIRRDW QQTRDPLIKT SLNAKIKFIR
760 770 780 790 800
LMLQTHREDE WDKYLNSLNH SENSIYKLNR GLLKKRPATH PLLGPNGLSY
810 820 830 840 850
SAVEKTEIIA DSLERQFSTF QGQDIPEVTE STTTIRGSVI KKPYLFTTPG
860 870 880 890 900
SIQKIISKLE KNKAPGRDQI TNTALKFLPK NQLLNLTKII NGCFNLCYFP
910 920 930 940 950
SIWKLSSIIS IPKPGKNHQL PENYRPIALL SSLSKIYERL ILQYLQKSLN
960 970 980 990 1000
GKIRDEQFAF RQNHSTVLQL TKLIDKISEN LNQGIQTAAI FLDVEKAFDT
1010 1020 1030 1040 1050
VWHDGLLHKM MSMNIPLQLI KITESFLSDR TFSVKIENQN SAVRKANAGV
1060 1070 1080 1090 1100
PQGSCLSPTL FNIYTNDLPT NINSRVSLFA DDTMFYCSNH NARFASLQLQ
1110 1120 1130 1140 1150
KQVNLASDWF KKWRLRINES KTIAILFGRT KTTNIKNIQL NNIQIPWSRC
1160 1170 1180 1190 1200
VKYLGVTIDH KLNFSTHASN IVKKATQIRG LLYSILNKKS PIPTRTKLNL
1210 1220 1230 1240 1250
FKMYIIPILT YAGEAWAPFI STSTWRKIEA VQTIGIRIIL GQPSIVKNSI
1260 1270 1280 1290 1300
LLHTTGFIPI KHLIKKYALA TFHRISTSQY IHIKNIGQTP HQSQASRHKQ
1310
RPRVKLWAIN
Length:1,310
Mass (Da):147,264
Last modified:May 14, 2014 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iED9384F4BF20A9C0
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
ABLF02036316 Genomic DNA No translation available.
ABLF02036319 Genomic DNA No translation available.
ABLF02048663 Genomic DNA No translation available.
ABLF02066977 Genomic DNA No translation available.

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
ACYPI38920-RA; ACYPI38920-PA; ACYPI38920

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABLF02036316 Genomic DNA No translation available.
ABLF02036319 Genomic DNA No translation available.
ABLF02048663 Genomic DNA No translation available.
ABLF02066977 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblMetazoaiACYPI38920-RA; ACYPI38920-PA; ACYPI38920

Phylogenomic databases

eggNOGiKOG1075, Eukaryota
HOGENOMiCLU_000680_38_0_1
InParanoidiJ9LC21
OrthoDBi1587309at2759

Family and domain databases

Gene3Di3.60.10.10, 1 hit
InterProiView protein in InterPro
IPR043502, DNA/RNA_pol_sf
IPR036691, Endo/exonu/phosph_ase_sf
IPR005135, Endo/exonuclease/phosphatase
IPR000477, RT_dom
PfamiView protein in Pfam
PF14529, Exo_endo_phos_2, 1 hit
PF00078, RVT_1, 1 hit
SUPFAMiSSF56219, SSF56219, 1 hit
SSF56672, SSF56672, 1 hit
PROSITEiView protein in PROSITE
PS50878, RT_POL, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiJ9LC21_ACYPI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: J9LC21
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 31, 2012
Last sequence update: May 14, 2014
Last modified: August 12, 2020
This is version 36 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported, Transposable elementARBA annotation
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