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Protein

General transcription factor IIH subunit 4

Gene

LOC100160821

Organism
Acyrthosiphon pisum (Pea aphid)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDNA damage, DNA repairUniRule annotation, Transcription, Transcription regulationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
General transcription factor IIH subunit 4UniRule annotation
Gene namesi
Name:LOC100160821Imported
OrganismiAcyrthosiphon pisum (Pea aphid)Imported
Taxonomic identifieri7029 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraParaneopteraHemipteraSternorrhynchaAphidomorphaAphidoideaAphididaeMacrosiphiniAcyrthosiphon
Proteomesi
  • UP000007819 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi7029.ACYPI002092-PA

Family & Domainsi

Sequence similaritiesi

Belongs to the TFB2 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3471 Eukaryota
COG5144 LUCA
InParanoidiJ9JPA9
KOiK03144
OMAiYLEQYAH
PhylomeDBiJ9JPA9

Family and domain databases

InterProiView protein in InterPro
IPR004598 TFIIH_p52/Tfb2
PANTHERiPTHR13152 PTHR13152, 1 hit
PfamiView protein in Pfam
PF03849 Tfb2, 1 hit
TIGRFAMsiTIGR00625 tfb2, 1 hit

Sequencei

Sequence statusi: Complete.

J9JPA9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKEPSTSKE KRKNLRKDDG SKILKVLTLY EYLIKLPEAV QDRLYSHPPT
60 70 80 90 100
CLTVFRVLPD ITQQFTLRIL FIEQPVPQSV LSSWVPANYS RELDESIEVA
110 120 130 140 150
TNLHIWKLTS VSGGLKGWIL NSTFKKKLKV ALMGGGRSTV PNSDMTADPK
160 170 180 190 200
ARDIDFLDSY AYERWECILH YMVGSKHEGI SSDAVRVLLN AGLMVRDTDD
210 220 230 240 250
SPVITSTGFQ FLLLDMATQV WYFMLRYMET VESRGLDLAQ CLTFLFQIHL
260 270 280 290 300
GTLGWDYITD EMSENLQAFL QHLREFGLVY QRKRKAGRFY PTRLVIEMGQ
310 320 330 340 350
GNSRTSERMK NKERYIVVET NFRIYAMTDS DLKVALVALF THMLYRFPNM
360 370 380 390 400
SAGILTRDSV RTALRSGITA AQIVRFLTVH THPQMQECGM PQTVIDQIYL
410 420 430 440 450
WENERNRLTY TDGVLYSNIN TPNDYETIKN YAADIGALVW CDERRRNIVV
460 470
STDGHDDVRK FWKKQPKSDP F
Length:471
Mass (Da):54,344
Last modified:October 31, 2012 - v1
Checksum:i663F76EEB74D6661
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABLF02030671 Genomic DNA No translation available.
RefSeqiXP_001945987.1, XM_001945952.3
UniGeneiAps.35152
Aps.74610

Genome annotation databases

EnsemblMetazoaiACYPI002092-RA; ACYPI002092-PA; ACYPI002092
GeneIDi100160821
KEGGiapi:100160821

Similar proteinsi

Entry informationi

Entry nameiJ9JPA9_ACYPI
AccessioniPrimary (citable) accession number: J9JPA9
Entry historyiIntegrated into UniProtKB/TrEMBL: October 31, 2012
Last sequence update: October 31, 2012
Last modified: February 28, 2018
This is version 32 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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