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Entry version 42 (16 Jan 2019)
Sequence version 2 (14 May 2014)
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Protein
Submitted name:

Uncharacterized protein

Gene
N/A
Organism
Acyrthosiphon pisum (Pea aphid)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-bindingPROSITE-ProRule annotation
Biological processRNA-mediated gene silencingSAAS annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAcyrthosiphon pisum (Pea aphid)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7029 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraParaneopteraHemipteraSternorrhynchaAphidomorphaAphidoideaAphididaeMacrosiphiniAcyrthosiphon
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007819 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7029.ACYPI000864-PA

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini23 – 164Helicase ATP-bindingInterPro annotationAdd BLAST142
Domaini410 – 578Helicase C-terminalInterPro annotationAdd BLAST169
Domaini609 – 704Dicer dsRNA-binding foldInterPro annotationAdd BLAST96
Domaini912 – 1031PAZInterPro annotationAdd BLAST120
Domaini1337 – 1483RNase IIIInterPro annotationAdd BLAST147
Domaini1560 – 1717RNase IIIInterPro annotationAdd BLAST158

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the helicase family. Dicer subfamily.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0701 Eukaryota
COG0571 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
J9JL06

Database of Orthologous Groups

More...
OrthoDBi
1337630at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
J9JL06

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00048 DSRM, 1 hit
cd00079 HELICc, 1 hit
cd00593 RIBOc, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1520.10, 2 hits
3.30.160.380, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038248 Dicer_dimer_sf
IPR005034 Dicer_dimerisation_dom
IPR014720 dsRBD_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR003100 PAZ_dom
IPR036085 PAZ_dom_sf
IPR000999 RNase_III_dom
IPR036389 RNase_III_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03368 Dicer_dimer, 1 hit
PF00271 Helicase_C, 1 hit
PF02170 PAZ, 1 hit
PF00636 Ribonuclease_3, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00949 PAZ, 1 hit
SM00535 RIBOc, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF101690 SSF101690, 1 hit
SSF52540 SSF52540, 1 hit
SSF69065 SSF69065, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51327 DICER_DSRBF, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS50821 PAZ, 1 hit
PS00517 RNASE_3_1, 1 hit
PS50142 RNASE_3_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

J9JL06-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALTFDDYVN TKTFTPQEYQ VEILSSAKNK NVIISLEGIT NKVFVILKLI
60 70 80 90 100
QELAFKMHRK SEKRKWTLLV LEEAEVDQYM FSIRHLTDLK PLEIRSVDHS
110 120 130 140 150
DFINYDVIVT TENLCLEIFE KNCLHFDQLS LAIFNNCQKI IVENSTYFKI
160 170 180 190 200
CNFIKSNSQC RILGIVHPLF ELDSDPLFIE NQLKFISHKL FSSIETASDI
210 220 230 240 250
VSLLRSCCKP KEVLIECAVQ SEDFPNIGIK SIVQSLTDFL NDHNYNPENI
260 270 280 290 300
YGDDEELREE LKKIPCPKNV PLQMISEFSD VLKTMGPYCA DKVALTLLYR
310 320 330 340 350
IENLKVKTPY ERHYALLCIV STLLIQIRAK FDNIFYNYSN IDKVLKFSSP
360 370 380 390 400
RVLRIINTLK QFKPKSFNSN NNLAEVCKDQ EGNKDKIIKS KSAKRNCKLT
410 420 430 440 450
RRYYNKTHRK QRQSRDPCEE NVCAIILVNS KMTASVLYHL FLDLKNSNEE
460 470 480 490 500
DFGWIEPQYM VDNNADPITE PEEFEIERKT QENILKRFRQ RNCNVLIGTK
510 520 530 540 550
ELETGINLPR CNLVINYNLP LSYKSYLMSK SKARTLDAYY VLMFDEHATS
560 570 580 590 600
KILSCCQLYK DINQMLLSHC TLKDIDMEKE IYADRFNWFV SPFKPGKKED
610 620 630 640 650
SAFVDMATAI GLVNRYCAKL PSDTFTKLSP IWKIQSIVYE NQPMFVCSIR
660 670 680 690 700
LPINSPIKHE IHGHPMPCEI LAKRIAALEV CRQIYSQGQL DDTLQPITKE
710 720 730 740 750
SFHALFNTDE IIPDTEDSLI TCKTKDSMPG TYKRRQHYYK RTAEALNDCR
760 770 780 790 800
PVEGKPCHLY AILLNITCPI PEQENTKSRR IHPPEESIHG FGILTTKHIP
810 820 830 840 850
SIPAFPIYPR CGEVYVRLKR IKTDMFLTQH QLDNIATFLN YTFSNVLCFK
860 870 880 890 900
KCRVEFNPTT THNCYYIVPT LRDASGSIDV DWKILDNVQT FRDNKLSIIT
910 920 930 940 950
NEDRIHFQPD IEVLKDAVVT PWYRNQEQPE YFYVEEICTH LNPKSPFPDP
960 970 980 990 1000
TEKYKTFEDF YYHKYSLKIQ NLEQPLLDVD PTSARLNFLT PRYMNCKGEY
1010 1020 1030 1040 1050
LPTSSDATKR AKRYDLSHKQ ILVPELCNIH LFPASMWRDA VSLPSILYRI
1060 1070 1080 1090 1100
NALLLADEIR TIVAKDTSLG LVNLSFDHIW KPLDFGWPIK DVLIRRKEQK
1110 1120 1130 1140 1150
EISTIKVIEP VETVKRFIDE VEKEEKIDEL NDPNWMEIGT WSNDMADFAM
1160 1170 1180 1190 1200
NNIDNTTKER YSYPNSLMIQ SNSESSTFSD VESDDGIQVN GLCVEFKNTY
1210 1220 1230 1240 1250
LAEAVNKNDS KTNKLFFFKN NETSHSWTWN DHFHSVTEYN SNQQDEQIIN
1260 1270 1280 1290 1300
LIYKKNDEII INREVKSSSN IDSSSLLKLP WELNSNTGYG LSDINILLNN
1310 1320 1330 1340 1350
TSFMPEDDKC IKNEIYKNNK TIDSINEVND LQTETFSFDF QPDLNYHPGP
1360 1370 1380 1390 1400
SPSILLQALT TANAIDGYDL ERLETIGDSF LKYAVTAYLY CTHNNVHEGI
1410 1420 1430 1440 1450
LSDLRSNHVS NLNLYRLGKL KMFGERMIST KFEPRSNWLP PCYIGPHKLE
1460 1470 1480 1490 1500
KAVINSNISI TQHITNDKSI ADCVEALIGI VYIIIIPYNH QLFLKMFSFI
1510 1520 1530 1540 1550
GAYLISCGTR GALLFMSWLG ITVLNTLDDS KLGYLKLPPS PLLRNVNDPE
1560 1570 1580 1590 1600
GELTKLMDGF ESFEQHLGYY FQDRSYLLQA MTHASYYPNC LTDCYQRLEF
1610 1620 1630 1640 1650
LGDAVLDYLI TRHLYEDKRR HPPGALTDLR SALVNNTIFA SLAVKNGFHK
1660 1670 1680 1690 1700
YLKHLSPGLS EVVYRFVAIQ EENGHTIDEE FCFSGEDDFE DAEDVEAPKV
1710 1720 1730 1740 1750
LGDIFESVAG AIYLDSNMSL DAVWKVYHKI MENEIKQFSK NVPISPVREL
1760 1770 1780 1790 1800
LELEPNTAKF SKPEKLVDGR RVRVIVEILG KGVFKGIGRN YRIAKCTAAK
1810
CALNHLKEKI KK
Length:1,812
Mass (Da):209,433
Last modified:May 14, 2014 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8CB77E12BCAD40B2
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
ABLF02011712 Genomic DNA No translation available.

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
ACYPI000864-RA; ACYPI000864-PA; ACYPI000864

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABLF02011712 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protein-protein interaction databases

STRINGi7029.ACYPI000864-PA

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiACYPI000864-RA; ACYPI000864-PA; ACYPI000864

Phylogenomic databases

eggNOGiKOG0701 Eukaryota
COG0571 LUCA
InParanoidiJ9JL06
OrthoDBi1337630at2759
PhylomeDBiJ9JL06

Family and domain databases

CDDicd00048 DSRM, 1 hit
cd00079 HELICc, 1 hit
cd00593 RIBOc, 2 hits
Gene3Di1.10.1520.10, 2 hits
3.30.160.380, 1 hit
InterProiView protein in InterPro
IPR038248 Dicer_dimer_sf
IPR005034 Dicer_dimerisation_dom
IPR014720 dsRBD_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR003100 PAZ_dom
IPR036085 PAZ_dom_sf
IPR000999 RNase_III_dom
IPR036389 RNase_III_sf
PfamiView protein in Pfam
PF03368 Dicer_dimer, 1 hit
PF00271 Helicase_C, 1 hit
PF02170 PAZ, 1 hit
PF00636 Ribonuclease_3, 2 hits
SMARTiView protein in SMART
SM00949 PAZ, 1 hit
SM00535 RIBOc, 2 hits
SUPFAMiSSF101690 SSF101690, 1 hit
SSF52540 SSF52540, 1 hit
SSF69065 SSF69065, 2 hits
PROSITEiView protein in PROSITE
PS51327 DICER_DSRBF, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS50821 PAZ, 1 hit
PS00517 RNASE_3_1, 1 hit
PS50142 RNASE_3_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiJ9JL06_ACYPI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: J9JL06
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 31, 2012
Last sequence update: May 14, 2014
Last modified: January 16, 2019
This is version 42 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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