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Protein
Submitted name:

Centromere protein E

Gene

CENPE

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi86 – 93ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMotor proteinPROSITE-ProRule annotation
LigandATP-bindingPROSITE-ProRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CFA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-CFA-2132295 MHC class II antigen presentation
R-CFA-2467813 Separation of Sister Chromatids
R-CFA-2500257 Resolution of Sister Chromatid Cohesion
R-CFA-5663220 RHO GTPases Activate Formins
R-CFA-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-CFA-68877 Mitotic Prometaphase
R-CFA-983189 Kinesins

Names & Taxonomyi

Protein namesi
Submitted name:
Centromere protein EImported
Gene namesi
Name:CENPEImported
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)Imported
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Chromosome 32

Organism-specific databases

VGNCiVGNC:39103 CENPE

PTM / Processingi

Proteomic databases

PRIDEiJ9JHU7

Expressioni

Gene expression databases

BgeeiENSCAFG00000010836

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 329Kinesin motorInterPro annotationAdd BLAST324

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili338 – 365Sequence analysisAdd BLAST28
Coiled coili491 – 532Sequence analysisAdd BLAST42
Coiled coili554 – 602Sequence analysisAdd BLAST49
Coiled coili618 – 687Sequence analysisAdd BLAST70
Coiled coili713 – 740Sequence analysisAdd BLAST28
Coiled coili775 – 809Sequence analysisAdd BLAST35
Coiled coili824 – 851Sequence analysisAdd BLAST28
Coiled coili871 – 908Sequence analysisAdd BLAST38
Coiled coili916 – 953Sequence analysisAdd BLAST38
Coiled coili958 – 1006Sequence analysisAdd BLAST49
Coiled coili1037 – 1078Sequence analysisAdd BLAST42
Coiled coili1111 – 1179Sequence analysisAdd BLAST69
Coiled coili1187 – 1224Sequence analysisAdd BLAST38
Coiled coili1343 – 1370Sequence analysisAdd BLAST28
Coiled coili1379 – 1473Sequence analysisAdd BLAST95
Coiled coili1475 – 1554Sequence analysisAdd BLAST80
Coiled coili1579 – 1599Sequence analysisAdd BLAST21
Coiled coili1616 – 1685Sequence analysisAdd BLAST70
Coiled coili1700 – 1797Sequence analysisAdd BLAST98
Coiled coili1801 – 1828Sequence analysisAdd BLAST28
Coiled coili1847 – 1909Sequence analysisAdd BLAST63
Coiled coili1913 – 1975Sequence analysisAdd BLAST63
Coiled coili1990 – 2042Sequence analysisAdd BLAST53
Coiled coili2287 – 2314Sequence analysisAdd BLAST28
Coiled coili2338 – 2407Sequence analysisAdd BLAST70
Coiled coili2511 – 2552Sequence analysisAdd BLAST42

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

GeneTreeiENSGT00910000143992

Family and domain databases

Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR027640 Kinesin-like_fam
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
PANTHERiPTHR24115 PTHR24115, 1 hit
PfamiView protein in Pfam
PF00225 Kinesin, 1 hit
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM00129 KISc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit

Sequencei

Sequence statusi: Complete.

J9JHU7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEEGAVAVC VRVRPLNDRE EALGGDTQIY WKTDNNAIYQ VDGSKSFNFD
60 70 80 90 100
RVFHSNETTK HVYEEIAVPI IDSAIQGYNG TIFAYGQTAS GKTYTMMGSQ
110 120 130 140 150
DYLGVIPRAI HDIFQKIKKF PDREFLLRVS YMEIYNETIT DLLCDTQKMK
160 170 180 190 200
PLIIREDFNR NVYVADLTEE VVYTSDMALK WITKGEKNRH YGITKMNQRS
210 220 230 240 250
SRSHTIFRMI LESREKGEPS NCDGSVKVSH LNLVDLAGSE RAAQTGAEGV
260 270 280 290 300
RLKEGCNINR SLFILGQVIK KLSDGQVGGF INYRDSKLTR ILQNSLGGNA
310 320 330 340 350
KTRIICTVTP VSFDETLTTL QFASTAKYMK NTPYVNEVSS DEALLKRYRK
360 370 380 390 400
EIMDLKKQLE EVSLETRAQA MEKDQLAQLL EEKDLLQKVQ TEKIQNLTRM
410 420 430 440 450
LVTSSSLTSH QELKAKRKRR VTWCLGKINK MKDSNYINEF NMSTNITTRK
460 470 480 490 500
AALTVVGEID ESLCSESDVF SNTFDTLNET EWNPATKLLS QENLESELNS
510 520 530 540 550
LRANYDNLVL DYEQLRQEHE EMELKLKEKN DLDEFEALER KAEKDQEMQL
560 570 580 590 600
IHEISNLKNL VKHAEVYNQD LENELSSKVE LLREKEDQIK KLQKYIDSQK
610 620 630 640 650
SEDIKTDLSY SSESTEDLKQ MKQTLLDAET VVLDAKRESA FLRSENLELK
660 670 680 690 700
EKMKELRSRY KQMENDIQLY QRQLEAKKKM QVDLEKELQS SFNEITKLTS
710 720 730 740 750
LIDGKVPKGL LCNLELERKI TDFQRELNEK VEENEALHKE VKLLSALKSL
760 770 780 790 800
PSEIEMLRKE IHDKSEELYI ITSEREKLNS EVVQKESRIQ DLLEEIGKTK
810 820 830 840 850
NDLATIRLNY ESTDQEFQDF KNHHIELEQK YKMVLEENAR MNQELGNLSE
860 870 880 890 900
QAQKLGLSLD ALSNTELSPK SEELLQKTTE SQKRLNEVEE LKEQLESTGS
910 920 930 940 950
RLQTIEKEKT LIAEQLQQTL VEVRTLTQEK DDLKQLQESL QIERDQLKSD
960 970 980 990 1000
IQDTVNMNID TQEQLRNALE ALKQHQEVIN TLRLKIAEKT SRHLETEENL
1010 1020 1030 1040 1050
GEAKDEFQEE MVDTDKKQNL KAKNTQALVV NVEDNELTEQ QRNIFSLIQE
1060 1070 1080 1090 1100
KNELQRMLES VTAEKEQLKT DLRENIEMTI ENQEELRILG DELKKQQEIL
1110 1120 1130 1140 1150
VQEKNHTIKK EEELSRTYKK LAEVEEKLKE KNQQLQEKQL QLLSVQEEMS
1160 1170 1180 1190 1200
EMQKKMNEME NVNNEFRNRE LTLERIEMER LEVAQKLHEN DEEMKSLTKE
1210 1220 1230 1240 1250
RNDLKELQES FELEREQLEG FIREIEVTIP VLHEEQELLP NVKEVSATQG
1260 1270 1280 1290 1300
TMNEGEILKK QSKTKDSMTP ARIEIERLGL TAKLPESHEE IKSLTEERDN
1310 1320 1330 1340 1350
LKTIKEAVQV GQEQLKEDSR EMLAEDSLNI SEPQNKQEQS FDMKEREDEA
1360 1370 1380 1390 1400
EEIVSELEQL QEQLKAKEAP QPRVGMERLE MSEKLQEVLQ SETNQLKENM
1410 1420 1430 1440 1450
REIIAKHLET EEELKVARCH LKEQEETIDK LRVNLSERET ELSSLQKELE
1460 1470 1480 1490 1500
ITNNELQKKI QELHEKQQFM STKEITETQE KMSELEQLKE QLRVKDSSLQ
1510 1520 1530 1540 1550
NIESEKLKLT EKLQESQDKI KIVIKERDEL KRVQELLQME RDQLKANIKE
1560 1570 1580 1590 1600
IVAEEYQQTI STRNISKKTD QEANIERVIE SSDAESQEKI QELQEKEHQL
1610 1620 1630 1640 1650
LKMKTVSETQ EKICEMEHLK NQFEAQKSTL ENIEMENARL TQRLHENLEE
1660 1670 1680 1690 1700
MRSVTKERDD LRSIEETLKV ERDQLKENLR ETVIRDLEKQ EELRIARMHV
1710 1720 1730 1740 1750
KEHQETIDKL RGLVSEKTDE LSNMQIDLEN TNDALKTQIQ ELQEKEHQLL
1760 1770 1780 1790 1800
KVKNDLRENM YQTEQLKEQL QAQHSTLESV ETERLRLSQK LHENLEEIKC
1810 1820 1830 1840 1850
VTEERDTLKR AERTLRMEQC QLRESLREKE AQDLEKQEEL RIVCMHVKEH
1860 1870 1880 1890 1900
QETIDKLRGL VSEKTDEIAN MQMDLENSNA KLQEKIQQLK ANEHQLFKLK
1910 1920 1930 1940 1950
EDVSETQKKT SEIERLKKQL KGQSLTLDKI EMENLNLAQK LHENLEEMKS
1960 1970 1980 1990 2000
VMQERDNLKL ERDQLKTNLQ ETIARDLETQ QELKIALLHL KEHQETIDKF
2010 2020 2030 2040 2050
RERVSEKTTQ ISNIQKDLNK SKDELQKKDQ QNQKEIVKYE KRLQCNEKHH
2060 2070 2080 2090 2100
LTESLREKCS RIKELLKRYS EMYNHYECLT RLSLDLEKEI ETQKELSVTI
2110 2120 2130 2140 2150
KANLSLPHSQ IKQIEKLLAV NQRCSMEFHR IIKRFQYVLS QITKIKEEQH
2160 2170 2180 2190 2200
ESINKLEVVF IDEVEKHNEL VIKIQHLQQD FNVPSGELTD LKLSQKMDLR
2210 2220 2230 2240 2250
IEEILKDLSE NDFHLLKTEF QQVLSNRREI TQFLEEWLNT HFDIEKLKNG
2260 2270 2280 2290 2300
IQKENDNICQ VNNFYNNKII AIMNESTEFE ERYAIIAKEW ERDLNSVKEK
2310 2320 2330 2340 2350
NEQLFKNYQT LKLTRTSGIP VNSATEDNKN LHVTSGATQL TTEKIQELEA
2360 2370 2380 2390 2400
SLHEAKESAL HKENKIVKMQ KELEMTNDII AKLQSQVNES NKCLEKTKER
2410 2420 2430 2440 2450
IQLLQDKVAL GAKPYKEEIE DLKMKLVKMD LEKKKNAKEF EKEITSTKAT
2460 2470 2480 2490 2500
VEHQKEVIRV LRENLRRNQQ AQDTSIVSEY TDSQPPNKPL TCGGGSGIVQ
2510 2520 2530 2540 2550
STKALILKSG YIRLEKEISK LKQQNEQLIK QKNELLSNNH HLSNEVKTWK
2560 2570 2580 2590 2600
ERILKREAHR EVTCENSPQS PKVTITAPKK RPHTPSQCKE RNLQDPVPRE
2610 2620 2630 2640 2650
SPKSWFFDSR SKSLPSPHPV RYFDNSGLGL CPEEQIAGAE NVDPQPGLWH
2660
ASSGKDVPEC KTQ
Length:2,663
Mass (Da):311,918
Last modified:October 31, 2012 - v1
Checksum:i672A37ACAA1721F1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX03016796 Genomic DNA No translation available.
AAEX03016797 Genomic DNA No translation available.
RefSeqiXP_013965533.1, XM_014110058.1

Genome annotation databases

EnsembliENSCAFT00000043119; ENSCAFP00000036028; ENSCAFG00000010836
GeneIDi100855663

Similar proteinsi

Entry informationi

Entry nameiJ9JHU7_CANLF
AccessioniPrimary (citable) accession number: J9JHU7
Entry historyiIntegrated into UniProtKB/TrEMBL: October 31, 2012
Last sequence update: October 31, 2012
Last modified: July 18, 2018
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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