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Entry version 23 (02 Jun 2021)
Sequence version 1 (31 Oct 2012)
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Protein
Submitted name:

Transmembrane channel-like protein 8

Gene

OXYTRI_09529

Organism
Oxytricha trifallax
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.17.6.2, the calcium-dependent chloride channel (ca-clc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Transmembrane channel-like protein 8Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:OXYTRI_09529Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiOxytricha trifallaxImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1172189 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaSarAlveolataCiliophoraIntramacronucleataSpirotricheaStichotrichiaSporadotrichidaOxytrichidaeOxytrichinaeOxytricha
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006077 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei401 – 422HelicalSequence analysisAdd BLAST22
Transmembranei460 – 482HelicalSequence analysisAdd BLAST23
Transmembranei559 – 583HelicalSequence analysisAdd BLAST25
Transmembranei595 – 615HelicalSequence analysisAdd BLAST21
Transmembranei643 – 662HelicalSequence analysisAdd BLAST20
Transmembranei740 – 770HelicalSequence analysisAdd BLAST31
Transmembranei795 – 816HelicalSequence analysisAdd BLAST22

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini684 – 785TMCInterPro annotationAdd BLAST102

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni53 – 101DisorderedSequence analysisAdd BLAST49
Regioni132 – 174DisorderedSequence analysisAdd BLAST43

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili254 – 274Sequence analysisAdd BLAST21
Coiled coili282 – 330Sequence analysisAdd BLAST49
Coiled coili349 – 369Sequence analysisAdd BLAST21
Coiled coili532 – 552Sequence analysisAdd BLAST21
Coiled coili861 – 881Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi132 – 150Polar residuesSequence analysisAdd BLAST19
Compositional biasi157 – 174Polar residuesSequence analysisAdd BLAST18

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TMC family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
517632at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038900, TMC
IPR012496, TMC_dom

The PANTHER Classification System

More...
PANTHERi
PTHR23302, PTHR23302, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07810, TMC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

J9HU04-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNYYNRRGVG GNQKPYENTL NSIDQLDRLA NLDVKNLKIE DLLDDKKLNQ
60 70 80 90 100
ILGGGNQQPQ NQNYNPFLDY NNSNQLGPSA PLSQRNRDNN NVQSLQKGPS
110 120 130 140 150
YLKQNLVNDY ESQKPLLYQR KEQTYEQKKL NTANLQQNEG ILQPQVMPRQ
160 170 180 190 200
SRKQDGDEFN TQQNSLQQSK YNSKPVKFEG VPDALNLKSN DRTPINNNPS
210 220 230 240 250
QNQPEVVQMQ LPAFDENGMQ KPVFFLGADF DEHDPNFDPN VQEDLIDEET
260 270 280 290 300
LKKIEEFKQK FLNMKKKAEE AEQDLAYSSI KVEELVSKIK DLEGKKNEFK
310 320 330 340 350
DELVNETRQG AALRRKLADL EDDKISLEQQ LESGFKPNKF TKLKEVNLAK
360 370 380 390 400
HKQLMEEKAR REREEMKRQV LIGIDLQDKK MTQKFLLLLK KSNYDKSIEG
410 420 430 440 450
FFLFFKFLVN ISFFVLALFM IIILRHVFNY KYDFTSFCST GIFKMPCFTF
460 470 480 490 500
YSRFHTDDEF YYSLTLELFI IIGIFMSLYK WVQFDLLKKE RSLYEDQKKK
510 520 530 540 550
FSKIFFNMWD WSTNNSYESY QLKNALRMEI KLNIDEDKIK ETIKQRKSLE
560 570 580 590 600
KTKLFIRRIL TFILNTLILL CGWGLILLVN IYQSDIQNYF ESFSILKYVS
610 620 630 640 650
TFVATLCLSI INVAVPHLIK SITQLEAWDF QDQLIKQQVW RMYLAKIMNF
660 670 680 690 700
AIFVFIELEL ILGKRWFNNI TLVTFNENGQ NFDCKEDQVA IQIFKLLITE
710 720 730 740 750
LAIKLVIPFL KALGERFFFG LMKGRKQWQP EYLLSDDIVW LLYFQAIVWV
760 770 780 790 800
TLILYPFITV VIPMILFVLF KHHYFVLRNF KSKPKKSSNA NDTGFFIMIF
810 820 830 840 850
LNITFFSVSA LILLFMSQSL DHETWLTNSQ INCGPYPDLH SGQYSIEEQI
860 870 880 890
QRSEAASYIY YIEYQLQIEE LQKSITKLQR KIDYNKMAQL
Length:890
Mass (Da):105,074
Last modified:October 31, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i12301C4228853197
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AMCR01017645 Genomic DNA Translation: EJY69732.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
EJY69732; EJY69732; OXYTRI_09529

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AMCR01017645 Genomic DNA Translation: EJY69732.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

TCDBi1.A.17.6.2, the calcium-dependent chloride channel (ca-clc) family

Genome annotation databases

EnsemblProtistsiEJY69732; EJY69732; OXYTRI_09529

Phylogenomic databases

OrthoDBi517632at2759

Family and domain databases

InterProiView protein in InterPro
IPR038900, TMC
IPR012496, TMC_dom
PANTHERiPTHR23302, PTHR23302, 1 hit
PfamiView protein in Pfam
PF07810, TMC, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiJ9HU04_9SPIT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: J9HU04
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 31, 2012
Last sequence update: October 31, 2012
Last modified: June 2, 2021
This is version 23 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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