Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 39 (16 Jan 2019)
Sequence version 1 (31 Oct 2012)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein
Submitted name:

Type III restriction enzyme

Gene

WUBG_00070

Organism
Wuchereria bancrofti
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-bindingPROSITE-ProRule annotation
Biological processRNA-mediated gene silencingSAAS annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Type III restriction enzymeImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:WUBG_00070Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiWuchereria bancroftiImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6293 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaSpirurinaSpiruromorphaFilarioideaOnchocercidaeWuchereria

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini45 – 141Dicer dsRNA-binding foldInterPro annotationAdd BLAST97
Domaini354 – 465PAZInterPro annotationAdd BLAST112
Domaini894 – 1092RNase IIIInterPro annotationAdd BLAST199
Domaini1144 – 1307RNase IIIInterPro annotationAdd BLAST164
Domaini1332 – 1398DRBMInterPro annotationAdd BLAST67

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
J9F282

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00048 DSRM, 1 hit
cd00593 RIBOc, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1520.10, 1 hit
3.30.160.380, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038248 Dicer_dimer_sf
IPR005034 Dicer_dimerisation_dom
IPR014720 dsRBD_dom
IPR003100 PAZ_dom
IPR036085 PAZ_dom_sf
IPR000999 RNase_III_dom
IPR036389 RNase_III_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03368 Dicer_dimer, 1 hit
PF02170 PAZ, 1 hit
PF00636 Ribonuclease_3, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00949 PAZ, 1 hit
SM00535 RIBOc, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF101690 SSF101690, 1 hit
SSF69065 SSF69065, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51327 DICER_DSRBF, 1 hit
PS50137 DS_RBD, 1 hit
PS50821 PAZ, 1 hit
PS00517 RNASE_3_1, 1 hit
PS50142 RNASE_3_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

J9F282-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLLKRYQNVH NPPEPMISPN LETVDDIIAP YTVESTGAQV TLTTAISLVN
60 70 80 90 100
RYCAKLPSDI FTRLVPQNTI VPETIGDRVM YRAELLLPIN SPIKETIKLK
110 120 130 140 150
KPLESKKLAQ MAVALEACRR LHKRKELNDY LLPVGKDTIM LTALDEDPDE
160 170 180 190 200
FIPNMSYKVG SARRRQLYDK RMAKALHNAI PHAGEECYIY VMEMDLIKAV
210 220 230 240 250
SGAANPKNRR IINPLDTEFC FGFLSNKKYR RYPKRQKVPS FPLFLRQGRM
260 270 280 290 300
QANIFLVKSR LLVDTQMLEL LKAFHHYLFD NVLRLVKGGL VFVPDKAPVN
310 320 330 340 350
VLIVPLRRER NSETGEVDFK LDYAYVRNVV SSIDELPRIP TEAERLAFKF
360 370 380 390 400
DAAKFQDAIV MPWYRDRDHP SFYYVAEIID AKPSSKFPDD KFITFNDYFI
410 420 430 440 450
QKYNIIIYDQ EQPLLDVDYT SSRLNLLMPR HWSRSKSRVT EERSSESGGI
460 470 480 490 500
SQGQILVPEL VDVHPIAASL WNVIAALPTL LYRINSLLLA DELRELVMRE
510 520 530 540 550
AFSNPNYNTS DDVYWLPLDY PTPMDDLEMK SVQKICDLKK KHVEQKSHME
560 570 580 590 600
AKDSGAGMTD FEIGVWDPEL AKGLEDFCLN REKHDEIKGF EDIDRDALGL
610 620 630 640 650
MNGSALRQHG DMSDDDDDDA VVLFDFINSV HERLGKESGD IFAPRENITS
660 670 680 690 700
SGWDDLIVIE ESAPNGINMP LSVNSGDSHI DSRGLMADLS RMSWLLDIPT
710 720 730 740 750
ILPSTAVDTA NQNDFGIKKE TVKLSNRRHP SVARKPAQLY LDSLERLEDS
760 770 780 790 800
DRGSSKSNRQ EECIDLIDFC DEVEEILSNG YDGTVPFDLR YFKGCLLDTD
810 820 830 840 850
VELDTAEVLS PKKISMHQDG KLIDEEMVRS SSDLELFLQI SHDNDATKLV
860 870 880 890 900
SSTADANAVD RKQEISAPVL DWMTFSFEED TFTDHPDGVS PCTLLQALTL
910 920 930 940 950
SNASDGISLE RLETVGDSFL KYAVTDYLFH TNPEQHEGKL SFARSKEVSN
960 970 980 990 1000
CNLYRLGRKH NLPSLIIGSK FDPNDGWLPP CYAPTSDFKA PNTLDAEERD
1010 1020 1030 1040 1050
KFIENVLEGK AVEGQETVKI PTGWDEADRN GQVRRIANGI ETIEFPKNMT
1060 1070 1080 1090 1100
TSWDGEEITP LPYNLLTQQS LGDKSIADAV ESLIGAHLLE LGPTATLKFM
1110 1120 1130 1140 1150
KWLGLKVLTE PVQMEQPLLR FIDTTDQPDK SLRKLNDLWI QFQFSKLEDC
1160 1170 1180 1190 1200
IGYRFNDRAY LLQAFTHASY YKNRITGCYQ RLEFLGDAVL DYVITRFLFQ
1210 1220 1230 1240 1250
HSSHYSPGVL TDLRSALVNN TIFASLAVKY NFHKHFIAMC PRLHHMIEKF
1260 1270 1280 1290 1300
VCLCAEKNLS SANFNEEMYM VTTEEEIDEG EEEDIEVPKA MGDIFESVAG
1310 1320 1330 1340 1350
AIYLDSGRSL NIVWRVFYNL MKETIDECCS NPPRSPIREL LEMEPERARF
1360 1370 1380 1390 1400
SKLERILETG KVRVTVDIQG KCRFTGMGRS YRIAKCTAAK RALRYLRSLK
1410
KEKERVAGKE
Length:1,410
Mass (Da):160,682
Last modified:October 31, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9FF42D2815887F6F
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
ADBV01000009 Genomic DNA Translation: EJW89016.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ADBV01000009 Genomic DNA Translation: EJW89016.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

InParanoidiJ9F282

Family and domain databases

CDDicd00048 DSRM, 1 hit
cd00593 RIBOc, 2 hits
Gene3Di1.10.1520.10, 1 hit
3.30.160.380, 1 hit
InterProiView protein in InterPro
IPR038248 Dicer_dimer_sf
IPR005034 Dicer_dimerisation_dom
IPR014720 dsRBD_dom
IPR003100 PAZ_dom
IPR036085 PAZ_dom_sf
IPR000999 RNase_III_dom
IPR036389 RNase_III_sf
PfamiView protein in Pfam
PF03368 Dicer_dimer, 1 hit
PF02170 PAZ, 1 hit
PF00636 Ribonuclease_3, 2 hits
SMARTiView protein in SMART
SM00949 PAZ, 1 hit
SM00535 RIBOc, 2 hits
SUPFAMiSSF101690 SSF101690, 1 hit
SSF69065 SSF69065, 2 hits
PROSITEiView protein in PROSITE
PS51327 DICER_DSRBF, 1 hit
PS50137 DS_RBD, 1 hit
PS50821 PAZ, 1 hit
PS00517 RNASE_3_1, 1 hit
PS50142 RNASE_3_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiJ9F282_WUCBA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: J9F282
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 31, 2012
Last sequence update: October 31, 2012
Last modified: January 16, 2019
This is version 39 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again