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Protein

Alanine racemase

Gene

IG3_01977

Organism
Bacillus cereus HuA2-1
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (IG3_01977), Alanine racemase (IG3_05967), Alanine racemase (IG3_01496)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei36Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei134SubstrateUniRule annotation1
Active sitei264Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei312Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotation
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayi
UPA00042;UER00497

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
ORF Names:IG3_01977Imported
OrganismiBacillus cereus HuA2-1Imported
Taxonomic identifieri1053201 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000004136 Componenti: Unassembled WGS sequence

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei36N6-(pyridoxal phosphate)lysineUniRule annotation1

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini243 – 371Ala_racemase_CInterPro annotationAdd BLAST129

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili172 – 192Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

OrthoDBiPOG091H022F

Family and domain databases

Gene3Di2.40.37.10, 1 hit
3.20.20.10, 1 hit
HAMAPiMF_01201 Ala_racemase, 1 hit
InterProiView protein in InterPro
IPR000821 Ala_racemase
IPR009006 Ala_racemase/Decarboxylase_C
IPR011079 Ala_racemase_C
IPR001608 Ala_racemase_N
IPR020622 Ala_racemase_pyridoxalP-BS
IPR029066 PLP-binding_barrel
PfamiView protein in Pfam
PF00842 Ala_racemase_C, 1 hit
PF01168 Ala_racemase_N, 1 hit
PRINTSiPR00992 ALARACEMASE
SMARTiView protein in SMART
SM01005 Ala_racemase_C, 1 hit
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR00492 alr, 1 hit
PROSITEiView protein in PROSITE
PS00395 ALANINE_RACEMASE, 1 hit

Sequencei

Sequence statusi: Complete.

J8YQY9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYRPIWAEIS LSNISHNISE FRRIIPNSTI IMATVKANAY GHGAVEVSKK
60 70 80 90 100
AINSGVDYLA VASLEEAIKL RKSDIQAPIL ILGYTPPSAS NHVVYWDLTQ
110 120 130 140 150
AIFDMEHAEA LSKSGQILGK KAKVHVKVDT GMGRLGLQAE EASDFIHNVS
160 170 180 190 200
QMDGLYLEGV YSHFATADEA DKRYAEKQKN RWKRLLEELE KRKVSIPLFH
210 220 230 240 250
IANSAATIEM PDMTYDMVRI GISMYGLYSS KEVNKTKINL KQAIQLKTKV
260 270 280 290 300
IYIQTLEKEY GVSYGATKIE RDKAIIATIP IGYADGYSRR LSGMAYVLIH
310 320 330 340 350
GQMAPVFGRI CMDFCMIDVT DIKGVNIGDE VVVYGGQGDY FISLDEVASM
360 370
LGTISYEVAC NLGQRVPRIY K
Length:371
Mass (Da):41,342
Last modified:October 31, 2012 - v1
Checksum:i60BC54A0F97B6B0B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AHDV01000014 Genomic DNA Translation: EJV85233.1
RefSeqiWP_002136390.1, NZ_JH804672.1

Genome annotation databases

EnsemblBacteriaiEJV85233; EJV85233; IG3_01977
PATRICifig|1053201.3.peg.2026

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AHDV01000014 Genomic DNA Translation: EJV85233.1
RefSeqiWP_002136390.1, NZ_JH804672.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiEJV85233; EJV85233; IG3_01977
PATRICifig|1053201.3.peg.2026

Phylogenomic databases

OrthoDBiPOG091H022F

Enzyme and pathway databases

UniPathwayi
UPA00042;UER00497

Family and domain databases

Gene3Di2.40.37.10, 1 hit
3.20.20.10, 1 hit
HAMAPiMF_01201 Ala_racemase, 1 hit
InterProiView protein in InterPro
IPR000821 Ala_racemase
IPR009006 Ala_racemase/Decarboxylase_C
IPR011079 Ala_racemase_C
IPR001608 Ala_racemase_N
IPR020622 Ala_racemase_pyridoxalP-BS
IPR029066 PLP-binding_barrel
PfamiView protein in Pfam
PF00842 Ala_racemase_C, 1 hit
PF01168 Ala_racemase_N, 1 hit
PRINTSiPR00992 ALARACEMASE
SMARTiView protein in SMART
SM01005 Ala_racemase_C, 1 hit
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR00492 alr, 1 hit
PROSITEiView protein in PROSITE
PS00395 ALANINE_RACEMASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiJ8YQY9_BACCE
AccessioniPrimary (citable) accession number: J8YQY9
Entry historyiIntegrated into UniProtKB/TrEMBL: October 31, 2012
Last sequence update: October 31, 2012
Last modified: November 7, 2018
This is version 42 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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