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Protein

3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ

Gene

fabZ

Organism
Neisseria meningitidis 93004
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.UniRule annotationSAAS annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

A (3R)-3-hydroxyacyl-[acyl-carrier protein] = a trans-2-enoyl-[acyl-carrier protein] + H2O.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei53UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotationSAAS annotationImported
Biological processLipid A biosynthesisUniRule annotationSAAS annotation, Lipid biosynthesis, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZUniRule annotation (EC:4.2.1.59UniRule annotation)
Alternative name(s):
(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydrataseUniRule annotation
Short name:
(3R)-hydroxymyristoyl-ACP dehydraseUniRule annotation
Beta-hydroxyacyl-ACP dehydrataseUniRule annotation
Gene namesi
Name:fabZUniRule annotationImported
ORF Names:NMEN93004_0220Imported
OrganismiNeisseria meningitidis 93004Imported
Taxonomic identifieri1069609 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria
Proteomesi
  • UP000003130 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliJ8WER6
SMRiJ8WER6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 140FabAInterPro annotationAdd BLAST125

Sequence similaritiesi

Belongs to the thioester dehydratase family. FabZ subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

OrthoDBiPOG091H005Q

Family and domain databases

HAMAPiMF_00406 FabZ, 1 hit
InterProiView protein in InterPro
IPR013114 FabA_FabZ
IPR010084 FabZ
IPR029069 HotDog_dom_sf
PfamiView protein in Pfam
PF07977 FabA, 1 hit
SUPFAMiSSF54637 SSF54637, 1 hit
TIGRFAMsiTIGR01750 fabZ, 1 hit

Sequencei

Sequence statusi: Complete.

J8WER6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDVQLPIEAK DIQKLIPHRY PFLQLDRITA FEPMKTLTAI KNVTINEPQF
60 70 80 90 100
QGHFPDLPVM PGVLIIEAMA QACGTLAILS EGGRKENEFF FFAGIDEARF
110 120 130 140
KRQVIPGDQL VFEVELLTSR RGIGKFNAVA KVDGQVAVEA IIMCAKRVV
Length:149
Mass (Da):16,627
Last modified:October 31, 2012 - v1
Checksum:i8B3D7B544D56C10E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ALXN01000006 Genomic DNA Translation: EJU57425.1
RefSeqiWP_002218583.1, NZ_ALXN01000006.1

Genome annotation databases

EnsemblBacteriaiEJU57425; EJU57425; NMEN93004_0220
PATRICifig|1069609.3.peg.266

Similar proteinsi

Entry informationi

Entry nameiJ8WER6_NEIME
AccessioniPrimary (citable) accession number: J8WER6
Entry historyiIntegrated into UniProtKB/TrEMBL: October 31, 2012
Last sequence update: October 31, 2012
Last modified: November 22, 2017
This is version 24 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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