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Entry version 42 (31 Jul 2019)
Sequence version 1 (31 Oct 2012)
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Protein

Transcription elongation factor Spt6

Gene

SU7_1269

Organism
Saccharomyces arboricola (strain H-6 / AS 2.3317 / CBS 10644) (Yeast)
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression.UniRule annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranscription, Transcription regulationUniRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcription elongation factor Spt6UniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:SU7_1269Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces arboricola (strain H-6 / AS 2.3317 / CBS 10644) (Yeast)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1160507 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1257 – 1354SH2InterPro annotationAdd BLAST98

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 216DisorderedSequence analysisAdd BLAST216
Regioni267 – 286DisorderedSequence analysisAdd BLAST20

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1224 – 1251Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 24PolyampholyteSequence analysisAdd BLAST24
Compositional biasi25 – 52AcidicSequence analysisAdd BLAST28
Compositional biasi87 – 104PolyampholyteSequence analysisAdd BLAST18
Compositional biasi160 – 194PolyampholyteSequence analysisAdd BLAST35

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SPT6 family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, SH2 domainPROSITE-ProRule annotation

Family and domain databases

Conserved Domains Database

More...
CDDi
cd09928 SH2_Cterm_SPT6_like, 1 hit
cd09918 SH2_Nterm_SPT6_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.2740, 1 hit
1.10.10.650, 1 hit
1.10.3500.10, 1 hit
3.30.420.140, 1 hit
3.30.505.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012337 RNaseH-like_sf
IPR010994 RuvA_2-like
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR028083 Spt6_acidic_N_dom
IPR042066 Spt6_death-like
IPR032706 Spt6_HHH
IPR028088 Spt6_HTH_DNA-bd_dom
IPR035420 Spt6_SH2
IPR035018 Spt6_SH2_C
IPR035019 Spt6_SH2_N
IPR028231 Spt6_YqgF
IPR023323 Tex-like_dom_sf
IPR023319 Tex-like_HTH_dom_sf
IPR017072 TF_Spt6
IPR006641 YqgF/RNaseH-like_dom
IPR037027 YqgF/RNaseH-like_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10145 PTHR10145, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14635 HHH_7, 1 hit
PF14641 HTH_44, 1 hit
PF14633 SH2_2, 1 hit
PF14632 SPT6_acidic, 1 hit
PF14639 YqgF, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF036947 Spt6, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00252 SH2, 1 hit
SM00732 YqgFc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47781 SSF47781, 1 hit
SSF53098 SSF53098, 1 hit
SSF55550 SSF55550, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50001 SH2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

J8PNF8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEDTGDSKLV PRDEEEIVND NDETKAPSDE EEGEDVFDSS EEDEDIDEDE
60 70 80 90 100
DEARKVQEGF IVNDDDENEG LETSISKKRR KHKRRVREED NRLSEDDLDL
110 120 130 140 150
LMENAGVERT KASSSSGKFK RLKRVGDEGN VAEPDNDNVA PSRQDSTSKL
160 170 180 190 200
EDFFSEDDEE EESVLRKGRS NEYGRDEEAH EDRDRRTDKG GILDELDDFI
210 220 230 240 250
EDDEFSDEDD ETRQRRIQEK KLLREQATKQ PTQITGLSSD KIDEMYDIFG
260 270 280 290 300
DGHDYDWALE IENEELENGN DNNQAQEEDI DEETGAIKST KKKISLQDIY
310 320 330 340 350
DLEDLKKNLM TDGDMKIRKT DIPERYQELR AGIADYGNMS SEDQELERNW
360 370 380 390 400
IAEKISVDKN FEATYDLTEF KEAIGNAIKF VTKENLEVPF IYAYRRNYIS
410 420 430 440 450
SREKDGFLLT EDDLWDIVSL DIEFHSLVNK KDYVERFYEE LHVDDPIVSE
460 470 480 490 500
YFKNQNTASI AELNSLQDIY DYLEFKYANE INEMFINHTG KTGKKHLKNS
510 520 530 540 550
SYEKFKASPL YQAVNDIGIS AEDVGENISS QHQIHPPVDH PSSKPVEVIE
560 570 580 590 600
SILNANSGDL QVFTSNTKLA IDTAQKYYSL ELSKNTKIRE KVRSDFSKYY
610 620 630 640 650
LADVVLTAKG KKEIQKGSLY EDIKYAINRT PMHFRRDPDV FLRMIEAESL
660 670 680 690 700
NLLSVKLHMS SQSQYIEHLF QIALETTNTS DIAVEWNNFR KLAFNQAMDK
710 720 730 740 750
IFQDISQEVK DNLTKNCQKL VSKTVRHKFM TKLDQAPFIP NVREPKIPKI
760 770 780 790 800
LALTCGQGRF GADAIIAVYV NRKGDFVRDY KIVDNPFDKM NPEKFEGTLD
810 820 830 840 850
NIIQSCQPNA IGINGPNPKT QKFYKKLQEV LHKKQIVDSR GHTIPIIYVE
860 870 880 890 900
DEVAIRYQNS ERAAQEFPNK PPLVKYCIAL ARYMHSPLLE YANLSNEEVK
910 920 930 940 950
SLSIHPHQNL LSQEQLTWAL ETAFVDIVNL VSVEVNRATD NNYYASALKY
960 970 980 990 1000
ISGFGKRKAI DFLQSLQRLN EPLLARQQLI THNILHKTIF MNSAGFLYIS
1010 1020 1030 1040 1050
WNEKRQKYED LEHDQLDSTR IHPEDYHLAT KVAADALEYD PDTIAEKEEQ
1060 1070 1080 1090 1100
GTMSEFIELL REDPDRRAKL ESLNLESYAE ELEKNTGLRK LNNLNTIVLE
1110 1120 1130 1140 1150
LLDGFEELRN DFHPLQGDEI FQSLTGESEK TFFKGSIIPV RVERFWHNDI
1160 1170 1180 1190 1200
ICTTNSEVEC IVNAQRHAGA QYRRPANEIY EIGKTYPAKV IYIDYANITA
1210 1220 1230 1240 1250
EVSLLDHDVK QQYVPISYSK DPSIWDLKQE LEDAEEERKL MMAEARAKRT
1260 1270 1280 1290 1300
HRVINHPYYF PFNGRQAEDY LRSKERGEFV IRQSSRGDDH LVITWKLDKD
1310 1320 1330 1340 1350
LFQHIDIQEL EKENPLALGK VLVVENQRYN DLDQIIVEYL QNKVRLLNEM
1360 1370 1380 1390 1400
TSSEKFKSGT KKDVVKFIED YSRVNPNKSV YYFSLNYDNP GWFYLMFKIN
1410 1420 1430 1440 1450
ANSKLYTWNV KLTNTGYFLV NYNYPSVIQL CNGFKTLLKS NSSKSRMNNY

H
Length:1,451
Mass (Da):168,455
Last modified:October 31, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE36E8F3675E6D1F2
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
ALIE01000088 Genomic DNA Translation: EJS43625.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
EJS43625; EJS43625; SU7_1269

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ALIE01000088 Genomic DNA Translation: EJS43625.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblFungiiEJS43625; EJS43625; SU7_1269

Family and domain databases

CDDicd09928 SH2_Cterm_SPT6_like, 1 hit
cd09918 SH2_Nterm_SPT6_like, 1 hit
Gene3Di1.10.10.2740, 1 hit
1.10.10.650, 1 hit
1.10.3500.10, 1 hit
3.30.420.140, 1 hit
3.30.505.10, 2 hits
InterProiView protein in InterPro
IPR012337 RNaseH-like_sf
IPR010994 RuvA_2-like
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR028083 Spt6_acidic_N_dom
IPR042066 Spt6_death-like
IPR032706 Spt6_HHH
IPR028088 Spt6_HTH_DNA-bd_dom
IPR035420 Spt6_SH2
IPR035018 Spt6_SH2_C
IPR035019 Spt6_SH2_N
IPR028231 Spt6_YqgF
IPR023323 Tex-like_dom_sf
IPR023319 Tex-like_HTH_dom_sf
IPR017072 TF_Spt6
IPR006641 YqgF/RNaseH-like_dom
IPR037027 YqgF/RNaseH-like_dom_sf
PANTHERiPTHR10145 PTHR10145, 1 hit
PfamiView protein in Pfam
PF14635 HHH_7, 1 hit
PF14641 HTH_44, 1 hit
PF14633 SH2_2, 1 hit
PF14632 SPT6_acidic, 1 hit
PF14639 YqgF, 1 hit
PIRSFiPIRSF036947 Spt6, 1 hit
SMARTiView protein in SMART
SM00252 SH2, 1 hit
SM00732 YqgFc, 1 hit
SUPFAMiSSF47781 SSF47781, 1 hit
SSF53098 SSF53098, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001 SH2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiJ8PNF8_SACAR
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: J8PNF8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 31, 2012
Last sequence update: October 31, 2012
Last modified: July 31, 2019
This is version 42 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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