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Protein

Sterol 24-C-methyltransferase

Gene

KNAG0B03670

Organism
Kazachstania naganishii (strain ATCC MYA-139 / BCRC 22969 / CBS 8797 / CCRC 22969 / KCTC 17520 / NBRC 10181 / NCYC 3082) (Yeast) (Saccharomyces naganishii)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + 5-alpha-cholesta-8,24-dien-3-beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5-alpha-cholest-8-en-3-beta-ol.UniRule annotation

Pathwayi: ergosterol biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes ergosterol from zymosterol.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Sterol 24-C-methyltransferase (KNAG0B03670)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. no protein annotated in this organism
This subpathway is part of the pathway ergosterol biosynthesis, which is itself part of Steroid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes ergosterol from zymosterol, the pathway ergosterol biosynthesis and in Steroid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferasePROSITE-ProRule annotation, Transferase
Biological processLipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesisUniRule annotation, Sterol metabolism
LigandS-adenosyl-L-methioninePROSITE-ProRule annotation

Enzyme and pathway databases

UniPathwayi
UPA00768;UER00760

Names & Taxonomyi

Protein namesi
Recommended name:
Sterol 24-C-methyltransferaseUniRule annotation (EC:2.1.1.41UniRule annotation)
Alternative name(s):
Delta(24)-sterol C-methyltransferaseUniRule annotation
Gene namesi
Name:KNAG0B03670Imported
Ordered Locus Names:KNAG_0B03670Imported
OrganismiKazachstania naganishii (strain ATCC MYA-139 / BCRC 22969 / CBS 8797 / CCRC 22969 / KCTC 17520 / NBRC 10181 / NCYC 3082) (Yeast) (Saccharomyces naganishii)Imported
Taxonomic identifieri1071383 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKazachstania
Proteomesi
  • UP000006310 Componenti: Chromosome 2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Structurei

3D structure databases

ProteinModelPortaliJ7S3M6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini77 – 372SAM_MT_ERG6_SMTInterPro annotationAdd BLAST296

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.PROSITE-ProRule annotation

Phylogenomic databases

OMAiENYTAFW
OrthoDBiEOG092C2LI4

Family and domain databases

InterProiView protein in InterPro
IPR013216 Methyltransf_11
IPR030384 MeTrfase_SMT
IPR029063 SAM-dependent_MTases
IPR013705 Sterol_MeTrfase_C
PfamiView protein in Pfam
PF08241 Methyltransf_11, 1 hit
PF08498 Sterol_MT_C, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
PROSITEiView protein in PROSITE
PS51685 SAM_MT_ERG6_SMT, 1 hit

Sequencei

Sequence statusi: Complete.

J7S3M6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTDTDNDSQL RQRQAEFSKE LHGEGAASRS GFSALLAKDK TAQREAVSKY
60 70 80 90 100
LKHWDGLTDK EAEERRLEDY NESTHSYYNV VTDFYEYGWG SSFHFCRFYK
110 120 130 140 150
GENFYAAMAR HEHYLAYAAG IQQGDLVLDV GCGVGGPARE ISRFTNCNVI
160 170 180 190 200
GLNNNDYQIE KAKYYAKKAG LQDKLDFVKG DFMHMEFEPE TFDKVYAIEA
210 220 230 240 250
TCHAPNLEKC YKEIYKVLKP GGKFAVYEWV MTSQYDETNE AHRKIAYEIE
260 270 280 290 300
LGDGIPKMFK VDTARQALEN CGFKVLVDED LAAKGDEVPW YYPLTGEWKY
310 320 330 340 350
VQTIADIGTF FRTSYLGRKV TSTMVSLMER FGIAPEGSSK VTAALEEAAV
360 370
GLVAGGREHL FTPMMLFVAQ KPMNDEQES
Length:379
Mass (Da):43,022
Last modified:October 31, 2012 - v1
Checksum:i805E01D05DC3BC9D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE978315 Genomic DNA Translation: CCK68809.1

Genome annotation databases

EnsemblFungiiCCK68809; CCK68809; KNAG_0B03670

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE978315 Genomic DNA Translation: CCK68809.1

3D structure databases

ProteinModelPortaliJ7S3M6
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCCK68809; CCK68809; KNAG_0B03670

Phylogenomic databases

OMAiENYTAFW
OrthoDBiEOG092C2LI4

Enzyme and pathway databases

UniPathwayi
UPA00768;UER00760

Family and domain databases

InterProiView protein in InterPro
IPR013216 Methyltransf_11
IPR030384 MeTrfase_SMT
IPR029063 SAM-dependent_MTases
IPR013705 Sterol_MeTrfase_C
PfamiView protein in Pfam
PF08241 Methyltransf_11, 1 hit
PF08498 Sterol_MT_C, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
PROSITEiView protein in PROSITE
PS51685 SAM_MT_ERG6_SMT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiJ7S3M6_KAZNA
AccessioniPrimary (citable) accession number: J7S3M6
Entry historyiIntegrated into UniProtKB/TrEMBL: October 31, 2012
Last sequence update: October 31, 2012
Last modified: November 7, 2018
This is version 29 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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