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Protein
Submitted name:

Polymerase/replicase

Gene

1

Organism
Infectious bronchitis virus
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHelicaseSAAS annotation, Hydrolase, MethyltransferaseSAAS annotation, Nucleotidyltransferase, Protease, RNA-bindingSAAS annotation, RNA-directed RNA polymeraseSAAS annotation, Thiol proteaseSAAS annotation, Transferase
Biological processActivation of host autophagy by virusSAAS annotation, Host-virus interaction, Viral RNA replicationSAAS annotation
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Polymerase/replicaseImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiInfectious bronchitis virusImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri11120 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesssRNA virusesssRNA positive-strand viruses, no DNA stageNidoviralesCoronaviridaeCoronavirinaeGammacoronavirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000150527 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1748 – 1764HelicalSequence analysisAdd BLAST17
Transmembranei1845 – 1872HelicalSequence analysisAdd BLAST28
Transmembranei1884 – 1909HelicalSequence analysisAdd BLAST26
Transmembranei2282 – 2300HelicalSequence analysisAdd BLAST19
Transmembranei2559 – 2581HelicalSequence analysisAdd BLAST23
Transmembranei2587 – 2608HelicalSequence analysisAdd BLAST22
Transmembranei2615 – 2632HelicalSequence analysisAdd BLAST18
Transmembranei2638 – 2666HelicalSequence analysisAdd BLAST29
Transmembranei3098 – 3118HelicalSequence analysisAdd BLAST21
Transmembranei3124 – 3141HelicalSequence analysisAdd BLAST18
Transmembranei3153 – 3176HelicalSequence analysisAdd BLAST24
Transmembranei3196 – 3213HelicalSequence analysisAdd BLAST18
Transmembranei3220 – 3239HelicalSequence analysisAdd BLAST20
Transmembranei3259 – 3282HelicalSequence analysisAdd BLAST24
Transmembranei3294 – 3321HelicalSequence analysisAdd BLAST28

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasmSAAS annotation, Host membraneSAAS annotation, Membrane

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1005 – 1181MacroInterPro annotationAdd BLAST177
Domaini1238 – 1499Peptidase C16InterPro annotationAdd BLAST262
Domaini2781 – 3087Peptidase C30InterPro annotationAdd BLAST307
Domaini4549 – 4711RdRp catalyticInterPro annotationAdd BLAST163
Domaini4870 – 4953CV ZBDInterPro annotationAdd BLAST84
Domaini5126 – 5478(+)RNA virus helicase C-terminalInterPro annotationAdd BLAST353

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the coronaviruses polyprotein 1ab family.SAAS annotation

Keywords - Domaini

RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysisSAAS annotation, Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.150.420, 1 hit
1.10.8.370, 1 hit
2.40.10.250, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027351 (+)RNA_virus_helicase_core_dom
IPR032505 Corona_NSP4_C
IPR009461 Coronavirus_NSP16
IPR027352 CV_ZBD
IPR037227 EndoU-like
IPR002589 Macro_dom
IPR036333 NSP10_sf
IPR009466 NSP11
IPR038123 NSP4_C_sf
IPR014828 NSP7
IPR037204 NSP7_sf
IPR014829 NSP8
IPR037230 NSP8_sf
IPR014822 NSP9
IPR036499 NSP9_sf
IPR027417 P-loop_NTPase
IPR008740 Peptidase_C30
IPR013016 Peptidase_C30/C16
IPR009003 Peptidase_S1_PA
IPR001205 RNA-dir_pol_C
IPR007094 RNA-dir_pol_PSvirus
IPR009469 RNA_pol_N_coronovir
IPR018995 RNA_synth_NSP10_coronavirus
IPR029063 SAM-dependent_MTases
IPR014827 Viral_protease

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16348 Corona_NSP4_C, 1 hit
PF06478 Corona_RPol_N, 1 hit
PF01661 Macro, 1 hit
PF09401 NSP10, 1 hit
PF06471 NSP11, 1 hit
PF06460 NSP16, 1 hit
PF08716 nsp7, 1 hit
PF08717 nsp8, 1 hit
PF08710 nsp9, 1 hit
PF05409 Peptidase_C30, 1 hit
PF00680 RdRP_1, 1 hit
PF01443 Viral_helicase1, 1 hit
PF08715 Viral_protease, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00506 A1pp, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF101816 SSF101816, 1 hit
SSF140367 SSF140367, 1 hit
SSF142877 SSF142877, 1 hit
SSF143076 SSF143076, 1 hit
SSF144246 SSF144246, 1 hit
SSF50494 SSF50494, 1 hit
SSF52540 SSF52540, 1 hit
SSF53335 SSF53335, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51653 CV_ZBD, 1 hit
PS51442 M_PRO, 1 hit
PS51154 MACRO, 1 hit
PS51124 PEPTIDASE_C16, 1 hit
PS51657 PSRV_HELICASE, 1 hit
PS50507 RDRP_SSRNA_POS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

J7I0T0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASSLKQGVS PKPRDVILVS KDIPEQLCDA LFFYTSHNPK DYADAFAFRQ
60 70 80 90 100
RFDRHLQTGK QFKFETVCGL FLLKGVDKIT PGVPAKVLKA TSKLADLEDI
110 120 130 140 150
FGVSPFARKY RELLKTACQW SLTVETLDVR AQTLDEIFDP TEILWLQVAA
160 170 180 190 200
KIQVSAMAMR RLVGEVTAKV MEALGSNLSA LFQIVEQQIA RIFQKALAIF
210 220 230 240 250
ESVSELPQRI AALKMAFSKC AKSITVVVME RTLVVREFAG TCLASINGAV
260 270 280 290 300
AKFFEELPSG FMGSKIFTTL AFFKEAAVKI VENIPNAPRG TKGFEVVGNA
310 320 330 340 350
KGTQVVVRGM RSDLTLLDQK ADIPVEPEGW SAILEGHLCY VFRSGDRFYA
360 370 380 390 400
APLSGNFALH DVHCCERVVC LSDGVTPEIN DGLILAAIYS SFSVYELVAA
410 420 430 440 450
LKKGEPFKFL GHKFVYAKDA AVSFTLAKAA TIADVLKLFQ STRVQVEDVW
460 470 480 490 500
SSLTEKSFEF WKLAYGKVRN LEEFVKTHFC KAQMSIVVLA AVLGDGIWHL
510 520 530 540 550
VSQVIYKLGG LFTNVVDFCG KYWKGFCAQL KKAKLIVTEN LCVLKGVAQH
560 570 580 590 600
CFQLLLDAIY ALYKSFKKCA LGRIHGDLLF WKGGVHKIVQ DGDEVWFDAI
610 620 630 640 650
DSLDVEDLGV VREKPIDFEV CEDVTLPENQ PGHMVQIEDD GKNYMFFRFK
660 670 680 690 700
KDENIYYTPM SQLGAINVVC KAGGKTVTFG DTTVKEIPPP DVVPIKVSIE
710 720 730 740 750
CCGEPWNTIF KKAYKEPIEV ETDLTVEQLL SVIYEKMCDG LKLFPEAPEP
760 770 780 790 800
PPFENVALVD KNGKDLDCIK SCHLIYRDYE SCDDIEEEDS EECDTESADA
810 820 830 840 850
EECDTASECE EEDEDTKVLA LIQDPASNKY PLPLDDDYSV YNGCIVHRDA
860 870 880 890 900
LDVVNLPSGE ETFVVNNCFE GAVKPLPQKV IDVLGDWGEA VDAQEQLCQQ
910 920 930 940 950
ESTQVVFEKS VESSTGGCEA VAAQAVVVEQ EVSSVFEEKS EVVVYTPADL
960 970 980 990 1000
EVVKETAEEV DEFILISGVP KEGFVSQEKE EPHVEQEPIP VVKPQREKKA
1010 1020 1030 1040 1050
KKFKVKPATC EKPKFLEYKT CVGDLTVVIA KALDEFKEFC VVNAANEHMS
1060 1070 1080 1090 1100
HGGGVAKAIA DFCGPDFVEY CEAYVNKHGP QQRLVTPSFV KGIQCVNNVV
1110 1120 1130 1140 1150
GPRHGDSNLR EKLVAAYRNV LVDGVFNYVV PVLSSGIFGV DFKMSIDAMR
1160 1170 1180 1190 1200
EAFDGCDIRV LLFSLSQEHI DYFDATCKQK VLYLTEDGIK YRSVVVKPGD
1210 1220 1230 1240 1250
SLSQFGQVFA RNKAVFTADD VEDKEILFIP TTDKTVLDYY CLDARKYVIY
1260 1270 1280 1290 1300
LQALAQKWNV QYRDNFVILE WRDGNCWVSS VVVLLQVAKI RFKGFLAEAW
1310 1320 1330 1340 1350
AKFLGGDPTD FVAWCYASCN AKVGDFSDAN WLLANLAEHF DADYTNALLK
1360 1370 1380 1390 1400
KRVSCNCGTK SYELRGLEAC IQPVRAPNLL HFKTQYSNCP TCGSNSVDEV
1410 1420 1430 1440 1450
VEASLPYLLL FATDGPAAVD CDENAVGTVV FIGSTNSGHC YTQAVGKAFD
1460 1470 1480 1490 1500
NLAQDRKFGK KSPYITAMYM RFSLKSESPL PVVKQSKGKT KVKENVSNLA
1510 1520 1530 1540 1550
TSSKVSFDNL TDFEQWYDSN IYDSLKVQET PDNFEGYVSF TTKEDSKLPL
1560 1570 1580 1590 1600
TLKVRGIKSV VDFKSKDGFT YKLTPDNDQN SKAPIYYPVL DSINLKAIWV
1610 1620 1630 1640 1650
EGTANFVVGH PNYYSKSLRI PTFWENAESF VKMGDKIDGV TMGLWRAEHL
1660 1670 1680 1690 1700
NKPNLEKIFN IAKKAFVGSS VVTTQCGKVI SKAATFIADK VGEGVVRNIT
1710 1720 1730 1740 1750
DRIKGLCGFT RGHFERKLSP QFIKTLIFFF FYFVKASAKS VVASYKSVLY
1760 1770 1780 1790 1800
KVVFTALFIL WFIYTSNPLM FTGIRVLDFL FEGSLCGPYN DYGKDSFDVL
1810 1820 1830 1840 1850
RYCTDDFTCR VCLHDRDSLH LYKHAYSVEQ IYKAASSGIV FNWSWLYLVF
1860 1870 1880 1890 1900
LILFVKPVAG FVIICYCVKY LVLSSTVLQT GVGFLDWFVQ TVFTNFNFMG
1910 1920 1930 1940 1950
AGFYFWLFYK IYIHVHHIMY CRDATCEVCK RVVRSNRQEV SVVVGGRKHI
1960 1970 1980 1990 2000
VHVYTNSGYN FCKRHNWYCR NCDDYGHQNT FMSPEVAGEL SEKLKRHIKP
2010 2020 2030 2040 2050
TAHAYHIVDD ACVVDDFVNL KYKAAIPGKD SASPAVKCFS VIDFLKKAVF
2060 2070 2080 2090 2100
LKDALKCEQI SNDSFIVCNT QSSHALEEAK NAAIYYAQYL CKPILILDQA
2110 2120 2130 2140 2150
FYDKLVVEPV SKSVVDKVCS ILSNIISVDT AALNYKAGTL RDCLLSVTND
2160 2170 2180 2190 2200
EEAVDMAIFC HNHDVEYTGD GFTNVIPSYG IDTDKLTPRD RGFLINADAS
2210 2220 2230 2240 2250
VANLRVKNAP PVVWKFSDLT KLSDSCLKHL ISATVKSGCR FFITKSGAKQ
2260 2270 2280 2290 2300
VFSCHTQKLL VEKKAGGIVG GTFKCVKSCF KWLLIFYVIF TACCLGYYYM
2310 2320 2330 2340 2350
EMNGSFVHPM YDFNSTLHVE GFKVIDKGVI RDIVPEDTCF SNKFVNFDSF
2360 2370 2380 2390 2400
WGKPYENSRN CPIVTAVIDG DGAVAAGIPG FVSWVMDGAM FIHMTQTDRK
2410 2420 2430 2440 2450
PWYIPTWFNR EIVGYTQDSI ITEGSFYTSI ALFSARCLYL TASNTPQLYC
2460 2470 2480 2490 2500
FNGDNDAPGA LPFGSIVPHR VYFQPNGVRL IVPQQILHTP YVVKFVSDSY
2510 2520 2530 2540 2550
CRGSVCEYTK PGYCVSLNSQ WVLFNDEYTI KPGVFCGSTV RELMFNMVST
2560 2570 2580 2590 2600
FFTGVNPNIY MQLATMFLIL VVVVLVFAMV IKFQGVFKAY ATIVFTIMLV
2610 2620 2630 2640 2650
WVVNAFVLCV HSYNSVLAVI LLVLYCYASL VTSRNTAIIM HCWLVFTFGL
2660 2670 2680 2690 2700
IVPIWLACCY LGFVLYMYTP LVLWCYGTTK NTRKLYDGNE FVGNYDLAAK
2710 2720 2730 2740 2750
STFVIRGSEF VKLTNEIGDK FEAYLSAYAR LKYYSGTGSE QDYLQACRAW
2760 2770 2780 2790 2800
LAYALDQYRN SGVEIVYTPP RYSIGVSRLQ AGFKKLVSPS SAVERCIVSV
2810 2820 2830 2840 2850
SYRGNSLNGL WLGDTIYCPR HVLGKFSGDQ WSDVLNLANN HEFEVATQNG
2860 2870 2880 2890 2900
VTLNVVSRRL RGAVLILQVA VANADTPKYK FVKANCGDSF TIACSYGGTV
2910 2920 2930 2940 2950
VGLYPVTMRS NGTIRASFLA GACGSVGFNI EKGVVNFFYM HHLELPNALH
2960 2970 2980 2990 3000
TGTDLMGDFY GGYVDEEVAQ RVPPDNLVTN NIVAWFYAAI ISVKESSFSL
3010 3020 3030 3040 3050
PKWLESTTVS VEDYNKWAGD NGFTPFSSST AITKLSAITG VDVCKLLRTI
3060 3070 3080 3090 3100
MVKSSQWGSD PILGQYNFED ELTPESVFNQ IGGVKLQSSI VRRATSWFWS
3110 3120 3130 3140 3150
RCVLACFLFV LCAIVLFTAV PLKYYVHAAV ILLTAVFFIS FTVKHVMAYM
3160 3170 3180 3190 3200
DTFLLPTLLT VIIGVCAEVP FIYNTLISQV VIFLSQWYDP VVFDTMVPWM
3210 3220 3230 3240 3250
LLPLVLYSAF KCVQGCYMNS FNTSLLMLYQ FMKLGFVIYT SSNTLTAYTE
3260 3270 3280 3290 3300
GNWELFFELV HTTVLANVSS NSLIGLIVFK CAKWMLYYCN ATYFNNYVLM
3310 3320 3330 3340 3350
AVMVNGIGWL CTCYFGLYWW VNKVFGLTLG KYNFKVSVDQ YRYMCLHKIK
3360 3370 3380 3390 3400
PPKTVWEVFS TNILIQGIGG DRVLPIATVQ SKLSDVKCTT VVLMQLLTKL
3410 3420 3430 3440 3450
NVEANSKMHA YLVELHNKIL ASDDVGECMD NLLGMLITLF CVDSTIDLSE
3460 3470 3480 3490 3500
YCDDILKRST VLQSVTQEFS HIPSYAEYER AKNLYEKVLA DSKNGSVTQQ
3510 3520 3530 3540 3550
ELAAYRKAAN IAKSVFDRDL AVQKKLDSMA ERAMTTMYKE ARVTDRRAKL
3560 3570 3580 3590 3600
VSSLHALLFA MLKKIDSEKL NVLFDQASSG VVPLATVPIV CSNKLTLVIP
3610 3620 3630 3640 3650
DPETWVKCVE GMHVTYSTVV WNIDTVIDAD GTELHPTSTG SGLTYCISGG
3660 3670 3680 3690 3700
NIAWPLKVNL TRNGHNKVDA ALQNNELMPH GVKTKACVAG VDQAHCSVES
3710 3720 3730 3740 3750
KCYYTNISGN SVVAAITSSN PNLKVASFLN EAGNQIYVDL DPPCKFGMKV
3760 3770 3780 3790 3800
GDKVEVVYLY FIKNTRSIVR GMVLGAISNV VVLQSKGHET EEVDAVGILS
3810 3820 3830 3840 3850
LCSFAVDPAD TYCKYVAAGN QPLGNCVKML TVHNGSGFAI TSKPSPTPDQ
3860 3870 3880 3890 3900
DSYGGASVCL YCRAHIAHPG GAGNLDGRCL LKGSFVQIPT TEKDPVGFCL
3910 3920 3930 3940 3950
RNKVCTVCQC WIGYGCQCDA LRQPKPSVQS AVGVADFDKN YLNRVRGSSE
3960 3970 3980 3990 4000
ARLIPLASGC DPDVVKRAFD VCNKESAGLF LNLKRNCARF QEVRDTEDGN
4010 4020 4030 4040 4050
LEYFDSYFVV KQTTPSNYEH ERSCYEDLKS DVTADHDFFV FNKNIYNISR
4060 4070 4080 4090 4100
QRLTKYTMMD LCYALRHFDP KDCEVLKEIL VTYGCIEDYH PKWFEENKDW
4110 4120 4130 4140 4150
YDPIENPKYY AMLAKMGPIV RRALLNAIEF GNLMVEKGYV GVVTLDNQDL
4160 4170 4180 4190 4200
NGKFYDFGDF QKTAPGAGVP VFDTYYSYMM PIIAMTDALA PERYFEYDVH
4210 4220 4230 4240 4250
KGYKSYDLLK YDYTVEKQEL FQKYFKYWDQ EYHPNCRDCS DDRCLIHCAN
4260 4270 4280 4290 4300
FNILFSTLIP QTSFGNLCRK VFVDGVPFIA TCGYHSKELG VIMNQDNTMS
4310 4320 4330 4340 4350
FSKMGLSQLM QFVGDPALLV GTSNNLVDLR TSCFSVCALA SGITHQTVKP
4360 4370 4380 4390 4400
GHFNKDFYDF AEKAGMFKEG SSIPLKHFFY PQTGNAAIND YDYYRYNRPT
4410 4420 4430 4440 4450
MFDIRQLLFC LEVTSKYFDC YEGGCIPASQ VVVNNLDKSA GYPFNKFGKA
4460 4470 4480 4490 4500
RLYYEMSLEE QDKLFESTKK NVLPTITQMN LKYAISAKNR ARTVAGVSIL
4510 4520 4530 4540 4550
STMTNRQFHQ KILKSIVSTR NAPVVIGTTK FYGGWDNMLR NLIQGVEDPI
4560 4570 4580 4590 4600
LMGWDYPKCD RAMPNLLRIA ASLVLARKHT NCCTWSERIY RLYNECAQVL
4610 4620 4630 4640 4650
SETVLATGGI YVKPGGTSSG DATTAYANSV FNIIQATSAN VARLLSVITR
4660 4670 4680 4690 4700
DIVYDDIKSL QYELYQQVYR RVNFDPAFVE KFYSYLCKNF SLMILSDDGV
4710 4720 4730 4740 4750
VCYNNTLAKQ GLVADISGFR EILYYQNNVY MADSKCWVEP DLEKGPHEFC
4760 4770 4780 4790 4800
SQHTMLVEVD GEPKYLPYPD PSRILGACVF VDEVDKTEPV AVMERYIALA
4810 4820 4830 4840 4850
IDAYPLVHHE NEEYKKVFFV LLSYIRKLYQ ELSQNMLMDY SFVMDIDKGS
4860 4870 4880 4890 4900
KFWEQEFYEN MYRAPTTLQS CGVCVVCNSQ TILRCGNCIR KPFLCCKCCY
4910 4920 4930 4940 4950
DHVMHTDHKN VLSINPYICS QPGCGEADVT KLYLGGMSYF CGNHKPKLSI
4960 4970 4980 4990 5000
PLVSNGTVFG IYRANCAGSE NVEDFNQLAT TNWSTVEPYI LANRCSDSLR
5010 5020 5030 5040 5050
RFAAETVKAT EELHKQQFAS AEVREVLSDR ELILSWEPGK TRPPLNRNYV
5060 5070 5080 5090 5100
FTGYHFTRTS KVQLGDFIFE KGEGKDVVYY RATSTAKLSV GDIFVLTSHN
5110 5120 5130 5140 5150
VVSLVAPTLC PQQTFSRFVN LRPNVMVPEC FVNNIPLYHL VGKQKRTTVQ
5160 5170 5180 5190 5200
GPPGSGKSHF AIGLAAYFSN ARVVFTACSH AAVDALCEKA FKFLKVDDCT
5210 5220 5230 5240 5250
RIVPQRTTID CFSKFKANDT GKKYIFSTIN ALPEVSCDIL LVDEVSMLTN
5260 5270 5280 5290 5300
YELSFINGKI NYQYVVYVGD PAQLPAPRTL LNGSLSPKDY NVVTNLMVCV
5310 5320 5330 5340 5350
KPDIFLAKCY RCPKEIVDTV STLVYDGKFI ANNPESRQCF KVIVNNGNSD
5360 5370 5380 5390 5400
VGHESGSAYN TTQLEFVKDF VCRNKEWREA TFISPYNAMN QRAYRMLGLN
5410 5420 5430 5440 5450
VQTVDSSQGS EYDYVIFCVT ADSPHALSIN RFNVALTRAK RGILVVMRQR
5460 5470 5480 5490 5500
DELYSALKFT ELGSETNLQG TGLFKICNKE FSGVHPAYAV TTKALAATYK
5510 5520 5530 5540 5550
VNDELAALVN VEAGSEITYK HLISLLGFKM SVSVEGCHNM FITRDEAIRN
5560 5570 5580 5590 5600
VRGWVGFDVE ATHACGTNIG TNLPFQVGFS TGADFVVTPE GLVDTSIGNN
5610 5620 5630 5640 5650
FEPVNSKAPP GEQFNHLRAL FKSAKPWHVI RPRIVQMLAD NLCNVSDCVV
5660 5670 5680 5690 5700
FVTWCHGLEL TTLRYFVKIG KEQLCTCGSR ATTFNSHTQA YACWKHCLGF
5710 5720 5730 5740 5750
DFVYNPLLVD IQQWGYSGNL LFNHNLHCNV HGHAHVASAD AIMTRCLAIN
5760 5770 5780 5790 5800
NAFCQDVNWD LTYPHIANED EVNSSCRYLQ RMYLNACVDA LKVNVVYDIG
5810 5820 5830 5840 5850
NPKGIKCVRR GDLSFRFYDK NPIVPNVKQF EYDYNQHKDK FADGLCMFWN
5860 5870 5880 5890 5900
CNVDCYPDNS LVCRYDTRNL SVFNLPGCNG GSLYVNKHAF HTPKFDRISF
5910 5920 5930 5940 5950
RNLKAMPFFF YDSSPCETIQ VDGVAQDLVS LATKDCITRC NIGGAVCKKH
5960 5970 5980 5990 6000
AQMYAEFVTS YNAAVTAGFT FWVSNQFNPY NLWKNFSALQ SIDNIAYNMY
6010 6020 6030 6040 6050
KGGHYDAIAG EIPTVITGDK VFVIDQGIEK AVFVNQTTLP TSVAFELYAK
6060 6070 6080 6090 6100
RNIRTLPNNR ILKGLGVDVT NGFVIWDYEN QTPLYRNTVK VCAYTDIEPN
6110 6120 6130 6140 6150
GLTVLYDDRY GDYQSFLAAD NAVLVSTQCY KRYSYVEIPS NLLVQNGMPL
6160 6170 6180 6190 6200
KDGANLYVYK RVNGAFVTLP NTLNTQGRSY ETFEPRSDVE RDFLDMSEED
6210 6220 6230 6240 6250
FVEKYGKDLG LQHILYGEVD KPQLGGLHTV IGMYRLLRVN KLNAKSVTNS
6260 6270 6280 6290 6300
DSDVIQNYFV LADNGSYKQV CTVVDLLLDD FLELLRIILK DYGTNKSKVV
6310 6320 6330 6340 6350
TVSIDYHSIN FMTWFEDGSI KTCYPQLQSA WTCGYNMPEL YKVQNCVMEP
6360 6370 6380 6390 6400
CNIPNYGVGI TLPSGIMMNV AKYTQLCQYL SKTTMCVPHN MRVMHFGAGS
6410 6420 6430 6440 6450
DKGVAPGSTV LKQWLPEGTL LVDNDIVDYV SDAHVSVFSD CNKYKTEHKF
6460 6470 6480 6490 6500
DLVISDMYTD NDSKRKHEGV VANNGNDDVF IYLSNFLKNN LALGGSFAVK
6510 6520 6530 6540 6550
VTETSWHESL YDIAQDCAWW TMFCTAVNAS SSEAFLLGIN YLGASDKVKV
6560 6570 6580 6590 6600
SGKTLHANYI FWRNCNYLQT SAYSAFDVAK FGLKLKATPV VNLKKEQKTD
6610 6620 6630
LVANLLRNGK LLIRDVGEVT VFSDHFVCTM
Length:6,630
Mass (Da):743,867
Last modified:October 31, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i749A94C28D9795AA
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
JQ977698 Genomic RNA Translation: AFQ31008.1

Keywords - Coding sequence diversityi

Ribosomal frameshiftingSAAS annotation

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JQ977698 Genomic RNA Translation: AFQ31008.1

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.10.150.420, 1 hit
1.10.8.370, 1 hit
2.40.10.250, 1 hit
InterProiView protein in InterPro
IPR027351 (+)RNA_virus_helicase_core_dom
IPR032505 Corona_NSP4_C
IPR009461 Coronavirus_NSP16
IPR027352 CV_ZBD
IPR037227 EndoU-like
IPR002589 Macro_dom
IPR036333 NSP10_sf
IPR009466 NSP11
IPR038123 NSP4_C_sf
IPR014828 NSP7
IPR037204 NSP7_sf
IPR014829 NSP8
IPR037230 NSP8_sf
IPR014822 NSP9
IPR036499 NSP9_sf
IPR027417 P-loop_NTPase
IPR008740 Peptidase_C30
IPR013016 Peptidase_C30/C16
IPR009003 Peptidase_S1_PA
IPR001205 RNA-dir_pol_C
IPR007094 RNA-dir_pol_PSvirus
IPR009469 RNA_pol_N_coronovir
IPR018995 RNA_synth_NSP10_coronavirus
IPR029063 SAM-dependent_MTases
IPR014827 Viral_protease
PfamiView protein in Pfam
PF16348 Corona_NSP4_C, 1 hit
PF06478 Corona_RPol_N, 1 hit
PF01661 Macro, 1 hit
PF09401 NSP10, 1 hit
PF06471 NSP11, 1 hit
PF06460 NSP16, 1 hit
PF08716 nsp7, 1 hit
PF08717 nsp8, 1 hit
PF08710 nsp9, 1 hit
PF05409 Peptidase_C30, 1 hit
PF00680 RdRP_1, 1 hit
PF01443 Viral_helicase1, 1 hit
PF08715 Viral_protease, 1 hit
SMARTiView protein in SMART
SM00506 A1pp, 1 hit
SUPFAMiSSF101816 SSF101816, 1 hit
SSF140367 SSF140367, 1 hit
SSF142877 SSF142877, 1 hit
SSF143076 SSF143076, 1 hit
SSF144246 SSF144246, 1 hit
SSF50494 SSF50494, 1 hit
SSF52540 SSF52540, 1 hit
SSF53335 SSF53335, 1 hit
PROSITEiView protein in PROSITE
PS51653 CV_ZBD, 1 hit
PS51442 M_PRO, 1 hit
PS51154 MACRO, 1 hit
PS51124 PEPTIDASE_C16, 1 hit
PS51657 PSRV_HELICASE, 1 hit
PS50507 RDRP_SSRNA_POS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiJ7I0T0_9GAMC
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: J7I0T0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 31, 2012
Last sequence update: October 31, 2012
Last modified: January 16, 2019
This is version 48 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
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