UniProtKB - J3SBQ3 (VSPD_CROAD)
Protein
Inactive snake venom serine proteinase 13
Gene
N/A
Organism
Crotalus adamanteus (Eastern diamondback rattlesnake)
Status
Functioni
Caution
Ala-206 is present instead of the conserved Ser which is expected to be an active site residue.Curated
GO - Molecular functioni
- serine-type endopeptidase activity Source: InterPro
- toxin activity Source: UniProtKB-KW
Keywordsi
Molecular function | Serine protease homolog, Toxin |
Names & Taxonomyi
Protein namesi | Recommended name: Inactive snake venom serine proteinase 13Short name: SVSP |
Organismi | Crotalus adamanteus (Eastern diamondback rattlesnake) |
Taxonomic identifieri | 8729 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Serpentes › Colubroidea › Viperidae › Crotalinae › Crotalus |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | Sequence analysisAdd BLAST | 18 | |
PropeptideiPRO_0000425647 | 19 – 24 | By similarity | 6 | |
ChainiPRO_0000425648 | 25 – 262 | Inactive snake venom serine proteinase 13Add BLAST | 238 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 31 ↔ 162 | PROSITE-ProRule annotation | ||
Disulfide bondi | 49 ↔ 65 | PROSITE-ProRule annotation | ||
Glycosylationi | 78 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 97 ↔ 257 | PROSITE-ProRule annotation | ||
Glycosylationi | 102 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 141 ↔ 211 | PROSITE-ProRule annotation | ||
Glycosylationi | 153 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 173 ↔ 190 | PROSITE-ProRule annotation | ||
Disulfide bondi | 201 ↔ 226 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinExpressioni
Tissue specificityi
Expressed by the venom gland.
Interactioni
Subunit structurei
Monomer.
By similarityFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 25 – 250 | Peptidase S1PROSITE-ProRule annotationAdd BLAST | 226 |
Sequence similaritiesi
Keywords - Domaini
SignalFamily and domain databases
CDDi | cd00190, Tryp_SPc, 1 hit |
Gene3Di | 2.40.10.10, 2 hits |
InterProi | View protein in InterPro IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR001314, Peptidase_S1A IPR001254, Trypsin_dom IPR018114, TRYPSIN_HIS |
Pfami | View protein in Pfam PF00089, Trypsin, 1 hit |
PRINTSi | PR00722, CHYMOTRYPSIN |
SMARTi | View protein in SMART SM00020, Tryp_SPc, 1 hit |
SUPFAMi | SSF50494, SSF50494, 1 hit |
PROSITEi | View protein in PROSITE PS50240, TRYPSIN_DOM, 1 hit PS00134, TRYPSIN_HIS, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
J3SBQ3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGLIRVLANL LILQLSYAQK SSELVIGGDE CNINEHRFLA IVHTDISLCT
60 70 80 90 100
GTLINQEWVL TAAHCDGGNM DIYLGVHNES VRYDDEEGRV PAEKFFCLSS
110 120 130 140 150
RNFTKWDKDI MLIRLNIPVR NSAHIAPLSL PSSPPSVGSV CRVMGWGTIT
160 170 180 190 200
SPNETYPDVP HCANINLFDY EVCLAAYPEF GLPATSKTLC AGILEGGKDT
210 220 230 240 250
CVGDAGGPLI CNGQFQGILS WGDDPCAQPR LPAVYTKVFD HLDWIQSIIA
260
GNTDATCPFV NF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | JU173724 mRNA Translation: AFJ49250.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | JU173724 mRNA Translation: AFJ49250.1 |
3D structure databases
SMRi | J3SBQ3 |
ModBasei | Search... |
Family and domain databases
CDDi | cd00190, Tryp_SPc, 1 hit |
Gene3Di | 2.40.10.10, 2 hits |
InterProi | View protein in InterPro IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR001314, Peptidase_S1A IPR001254, Trypsin_dom IPR018114, TRYPSIN_HIS |
Pfami | View protein in Pfam PF00089, Trypsin, 1 hit |
PRINTSi | PR00722, CHYMOTRYPSIN |
SMARTi | View protein in SMART SM00020, Tryp_SPc, 1 hit |
SUPFAMi | SSF50494, SSF50494, 1 hit |
PROSITEi | View protein in PROSITE PS50240, TRYPSIN_DOM, 1 hit PS00134, TRYPSIN_HIS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | VSPD_CROAD | |
Accessioni | J3SBQ3Primary (citable) accession number: J3SBQ3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 19, 2014 |
Last sequence update: | October 31, 2012 | |
Last modified: | August 12, 2020 | |
This is version 23 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Animal Toxin Annotation Program | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Documents
- SIMILARITY comments
Index of protein domains and families - Peptidase families
Classification of peptidase families and list of entries