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Protein

Zinc metalloproteinase-disintegrin-like 2a

Gene
N/A
Organism
Crotalus adamanteus (Eastern diamondback rattlesnake)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Snake venom metalloproteinase that impairs hemostasis in the envenomed animal.By similarity

Miscellaneous

The disintegrin domain belongs to the long disintegrin subfamily.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi202Calcium 1By similarity1
Metal bindingi286Calcium 1By similarity1
Metal bindingi335Zinc; catalyticPROSITE-ProRule annotation1
Active sitei336PROSITE-ProRule annotation1
Metal bindingi339Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi345Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi390Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi393Calcium 1By similarity1
Metal bindingi405Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi408Calcium 2By similarity1
Metal bindingi410Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi412Calcium 2By similarity1
Metal bindingi415Calcium 2By similarity1
Metal bindingi418Calcium 2By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionCell adhesion impairing toxin, Hemostasis impairing toxin, Hydrolase, Metalloprotease, Protease, Toxin
LigandCalcium, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc metalloproteinase-disintegrin-like 2a (EC:3.4.24.-)
Alternative name(s):
Snake venom metalloproteinase
Short name:
SVMP
OrganismiCrotalus adamanteus (Eastern diamondback rattlesnake)
Taxonomic identifieri8729 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaViperidaeCrotalinaeCrotalus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
PropeptideiPRO_000042562321 – 189By similarityAdd BLAST169
ChainiPRO_0000425624190 – 612Zinc metalloproteinase-disintegrin-like 2aAdd BLAST423

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi218N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi310 ↔ 390By similarity
Disulfide bondi350 ↔ 374By similarity
Disulfide bondi352 ↔ 357By similarity
Disulfide bondi406 ↔ 435By similarity
Disulfide bondi417 ↔ 430By similarity
Disulfide bondi419 ↔ 425By similarity
Disulfide bondi429 ↔ 452By similarity
Disulfide bondi443 ↔ 449By similarity
Disulfide bondi448 ↔ 474By similarity
Disulfide bondi461 ↔ 481By similarity
Disulfide bondi468 ↔ 500By similarity
Disulfide bondi493 ↔ 505By similarity
Disulfide bondi512 ↔ 562By similarity
Disulfide bondi527 ↔ 573By similarity
Disulfide bondi540 ↔ 550By similarity
Disulfide bondi557 ↔ 599By similarity
Disulfide bondi593 ↔ 605By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Expressioni

Tissue specificityi

Expressed by the venom gland.

Structurei

3D structure databases

ProteinModelPortaliJ3S829
SMRiJ3S829
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini199 – 395Peptidase M12BPROSITE-ProRule annotationAdd BLAST197
Domaini403 – 489DisintegrinPROSITE-ProRule annotationAdd BLAST87

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi467 – 469D/ECD-tripeptide3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi490 – 612Cys-richAdd BLAST123

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

CDDicd04269 ZnMc_adamalysin_II_like, 1 hit
Gene3Di3.40.390.10, 1 hit
4.10.70.10, 1 hit
InterProiView protein in InterPro
IPR006586 ADAM_Cys-rich
IPR018358 Disintegrin_CS
IPR001762 Disintegrin_dom
IPR036436 Disintegrin_dom_sf
IPR024079 MetalloPept_cat_dom_sf
IPR001590 Peptidase_M12B
IPR002870 Peptidase_M12B_N
IPR034027 Reprolysin_adamalysin
PfamiView protein in Pfam
PF08516 ADAM_CR, 1 hit
PF00200 Disintegrin, 1 hit
PF01562 Pep_M12B_propep, 1 hit
PF01421 Reprolysin, 1 hit
PRINTSiPR00289 DISINTEGRIN
SMARTiView protein in SMART
SM00608 ACR, 1 hit
SM00050 DISIN, 1 hit
SUPFAMiSSF57552 SSF57552, 1 hit
PROSITEiView protein in PROSITE
PS50215 ADAM_MEPRO, 1 hit
PS00427 DISINTEGRIN_1, 1 hit
PS50214 DISINTEGRIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

J3S829-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIQVLLVTIC LAVFPYQGSS IILGSGNVND YEVVYPRKVT ALPKGAAQPK
60 70 80 90 100
YEDTMQYEFK VNGEPVVLHL EKNKGLFSED YSETHYSPDG REITTYPPVE
110 120 130 140 150
DHCYYHGRIQ NDADSTASIS ACNGLKGHFK LQGEMYLIEP LELSDSEAHA
160 170 180 190 200
VFKYENVEKE DEAPKMCGVT QNWESYEPIK KASQLNLTPE QQRYLNTKKY
210 220 230 240 250
IELVIVADNV MVKKYTSNST AIRTRIYACV NTLNLIYRAF NIHIALVGIE
260 270 280 290 300
IWSNKDLINV ISASNVTLDL FGNWRRRVLL RRKRHDNAQL LTAIDLDGPT
310 320 330 340 350
IGLARVGSMC DPKCSTGIVQ DHSKLDVMVA VTMAHELAHN LGINHDGNQC
360 370 380 390 400
NCGGNPCIMS ATLNFEPAYR FSDCSRDEHW RYLIDNRPPC ILNKPLITDI
410 420 430 440 450
VSPPVCGNYF VEVGEECDCG LPAHCQNPCC NAATCKLRPG TQCEDGECCE
460 470 480 490 500
QCQFTSAGTE CRAAKSECDI AESCTGQSAD CPTDNFQRNG RPCLNNNGYC
510 520 530 540 550
YNGKCPTLDH QCISFFGSSA TVAPDVCFNL NLKGEGNFYC RRENTRIFPC
560 570 580 590 600
APQDKKCGRL FCVLGPTGNT ISCQSTYSQS DLDIGMVDLG TKCGDGRVCN
610
STRQCVDVNT AY
Length:612
Mass (Da):67,944
Last modified:October 31, 2012 - v1
Checksum:i1C8183C2CBAF112C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JU173707 mRNA Translation: AFJ49233.1

Similar proteinsi

Entry informationi

Entry nameiVM32A_CROAD
AccessioniPrimary (citable) accession number: J3S829
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 19, 2014
Last sequence update: October 31, 2012
Last modified: November 22, 2017
This is version 24 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program
Annotation programChordata Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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