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UniProtKB - J3QTB0 (J3QTB0_HUMAN)
Protein
Submitted name:
Short transient receptor potential channel 3
Gene
TRPC3
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- calcium channel activity Source: InterPro
Keywordsi
Biological process | Ion transportARBA annotation, Transport |
Names & Taxonomyi
Protein namesi | Submitted name: Short transient receptor potential channel 3Imported |
Gene namesi | Name:TRPC3Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:12335, TRPC3 |
VEuPathDBi | HostDB:ENSG00000138741 |
Subcellular locationi
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 328 – 347 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 378 – 395 | HelicalSequence analysisAdd BLAST | 18 | |
Transmembranei | 416 – 437 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 525 – 545 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 565 – 581 | HelicalSequence analysisAdd BLAST | 17 | |
Transmembranei | 593 – 615 | HelicalSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSG00000138741, Expressed in buccal mucosa cell and 132 other tissues |
ExpressionAtlasi | J3QTB0, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 194 – 256 | TRP_2InterPro annotationAdd BLAST | 63 | |
Domaini | 363 – 626 | Ion_transInterPro annotationAdd BLAST | 264 |
Keywords - Domaini
ANK repeatARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00990000203539 |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR036770, Ankyrin_rpt-contain_sf IPR005821, Ion_trans_dom IPR013555, TRP_dom IPR005459, TRPC3_channel IPR002153, TRPC_channel |
PANTHERi | PTHR10117, PTHR10117, 2 hits PTHR10117:SF8, PTHR10117:SF8, 2 hits |
Pfami | View protein in Pfam PF12796, Ank_2, 1 hit PF00520, Ion_trans, 1 hit PF08344, TRP_2, 1 hit |
PRINTSi | PR01097, TRNSRECEPTRP |
SMARTi | View protein in SMART SM00248, ANK, 3 hits |
SUPFAMi | SSF48403, SSF48403, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
J3QTB0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEGSPSLRRM TVMREKGRRQ AVRGPAFMFN DRGTSLTAEE ERFLDAAEYG
60 70 80 90 100
NIPVVRKMLE ESKTLNVNCV DYMGQNALQL AVGNEHLEVT ELLLKKENLA
110 120 130 140 150
RIGDALLLAI SKGYVRIVEA ILNHPGFAAS KRLTLSPCEQ ELQDDDFYAY
160 170 180 190 200
DEDGTRFSPD ITPIILAAHC QKYEVVHMLL MKGARIERPH DYFCKCGDCM
210 220 230 240 250
EKQRHDSFSH SRSRINAYKG LASPAYLSLS SEDPVLTALE LSNELAKLAN
260 270 280 290 300
IEKEFKNDYR KLSMQCKDFV VGVLDLCRDS EEVEAILNGD LESAEPLEVH
310 320 330 340 350
RHKASLSRVK LAIKYEVKKL GKILRSPFMK FVAHAASFII FLGLLVFNAS
360 370 380 390 400
DRFEGITTLP NITVTDYPKQ IFRVKTTQFT WTEMLIMVWV LGMMWSECKE
410 420 430 440 450
LWLEGPREYI LQLWNVLDFG MLSIFIAAFT ARFLAFLQAT KAQQYVDSYV
460 470 480 490 500
QESDLSEVTL PPEIQYFTYA RDKWLPSDPQ IISEGLYAIA VVLSFSRIAY
510 520 530 540 550
ILPANESFGP LQISLGRTVK DIFKFMVLFI MVFFAFMIGM FILYSYYLGA
560 570 580 590 600
KVNAAFTTVE ESFKTLFWSI FGLSEVTSVV LKYDHKFIEN IGYVLYGIYN
610 620 630 640 650
VTMVVVLLNM LIAMINSSYQ EIEDDSDVEW KFARSKLWLS YFDDGKTLPP
660 670 680 690 700
PFSLVPSPKS FVYFIMRIVN FPKCRRRRLQ KDIEMGMGNS KSRLNLFTQS
710 720 730 740 750
NSRVFESHSF NSILNQPTRY QQIMKRLIKR YVLKAQVDKE NDEVNEGELK
760 770 780 790
EIKQDISSLR YELLEDKSQA TEELAILIHK LSEKLNPSML RCE
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ13507 | TRPC3_HUMAN | Short transient receptor potential ... | TRPC3 TRP3 | 836 | Annotation score: | ||
D6RC49 | D6RC49_HUMAN | Short transient receptor potential ... | TRPC3 | 276 | Annotation score: | ||
D6R902 | D6R902_HUMAN | Short transient receptor potential ... | TRPC3 | 93 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC079341 Genomic DNA No translation available. AC108930 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000513531; ENSP00000426899; ENSG00000138741 |
UCSCi | uc010inr.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC079341 Genomic DNA No translation available. AC108930 Genomic DNA No translation available. |
3D structure databases
SMRi | J3QTB0 |
ModBasei | Search... |
Proteomic databases
PeptideAtlasi | J3QTB0 |
PRIDEi | J3QTB0 |
Protocols and materials databases
Antibodypediai | 15891, 282 antibodies from 33 providers |
Genome annotation databases
Ensembli | ENST00000513531; ENSP00000426899; ENSG00000138741 |
UCSCi | uc010inr.3, human |
Organism-specific databases
HGNCi | HGNC:12335, TRPC3 |
OpenTargetsi | ENSG00000138741 |
VEuPathDBi | HostDB:ENSG00000138741 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00990000203539 |
Miscellaneous databases
ChiTaRSi | TRPC3, human |
Gene expression databases
Bgeei | ENSG00000138741, Expressed in buccal mucosa cell and 132 other tissues |
ExpressionAtlasi | J3QTB0, baseline and differential |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR036770, Ankyrin_rpt-contain_sf IPR005821, Ion_trans_dom IPR013555, TRP_dom IPR005459, TRPC3_channel IPR002153, TRPC_channel |
PANTHERi | PTHR10117, PTHR10117, 2 hits PTHR10117:SF8, PTHR10117:SF8, 2 hits |
Pfami | View protein in Pfam PF12796, Ank_2, 1 hit PF00520, Ion_trans, 1 hit PF08344, TRP_2, 1 hit |
PRINTSi | PR01097, TRNSRECEPTRP |
SMARTi | View protein in SMART SM00248, ANK, 3 hits |
SUPFAMi | SSF48403, SSF48403, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | J3QTB0_HUMAN | |
Accessioni | J3QTB0Primary (citable) accession number: J3QTB0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 3, 2012 |
Last sequence update: | October 3, 2012 | |
Last modified: | January 19, 2022 | |
This is version 63 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |