Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Eukaryotic initiation factor 4A-I

Gene

EIF4A1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionHelicaseUniRule annotation, Hydrolase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Eukaryotic initiation factor 4A-IImported
Gene namesi
Name:EIF4A1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000161960.14
HGNCiHGNC:3282 EIF4A1

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000161960

PTM / Processingi

Proteomic databases

MaxQBiJ3QS69
PeptideAtlasiJ3QS69
PRIDEiJ3QS69

Expressioni

Gene expression databases

BgeeiENSG00000161960 Expressed in 88 organ(s), highest expression level in left coronary artery
ExpressionAtlasiJ3QS69 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliJ3QS69
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 60Q_MOTIFInterPro annotationAdd BLAST29
Domaini63 – 232Helicase ATP-bindingInterPro annotationAdd BLAST170

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi32 – 60Q motifPROSITE-ProRule annotationAdd BLAST29

Sequence similaritiesi

Belongs to the DEAD box helicase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0327 Eukaryota
COG0513 LUCA
GeneTreeiENSGT00530000062880

Family and domain databases

InterProiView protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR037583 EIF4A
IPR014001 Helicase_ATP-bd
IPR027417 P-loop_NTPase
IPR000629 RNA-helicase_DEAD-box_CS
IPR014014 RNA_helicase_DEAD_Q_motif
PANTHERiPTHR24031:SF226 PTHR24031:SF226, 1 hit
PfamiView protein in Pfam
PF00270 DEAD, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS00039 DEAD_ATP_HELICASE, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51195 Q_MOTIF, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 17 potential isoforms that are computationally mapped.Show allAlign All

J3QS69-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSASQDSRSR DNGPDGMEPE GVIESNWNEI VDSFDDMNLS ESLLRGIYAY
60 70 80 90 100
GFEKPSAIQQ RAILPCIKGY DVIAQAQSGT GKTATFAISI LQQIELDLKA
110 120 130 140 150
TQALVLAPTR ELAQQKVVMA LGDYMGASCH ACIGGTNVRA EVQKLQMEAP
160 170 180 190 200
HIIVGTPGRV FDMLNRRYLS PKYIKMFVLD EADEMLSRGF KDQIYDIFQK
210 220 230 240 250
LNSNTQVVLL SATMPSDVLE VTKKFMRDPI RILVKKEELT LEGIRQFYIN
260 270 280 290 300
VEREEWKLDT LCDLYETLTI TQAVIFINTR RKVDWLTEKM HARDFTVSAM
Length:300
Mass (Da):33,949
Last modified:October 3, 2012 - v1
Checksum:i90D68E9270D4AB37
GO

Computationally mapped potential isoform sequencesi

There are 17 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P60842IF4A1_HUMAN
Eukaryotic initiation factor 4A-I
EIF4A1 DDX2A, EIF4A
406Annotation score:
J3KT12J3KT12_HUMAN
Eukaryotic initiation factor 4A-I
EIF4A1
341Annotation score:
J3KTB5J3KTB5_HUMAN
Eukaryotic initiation factor 4A-I
EIF4A1
257Annotation score:
J3QL43J3QL43_HUMAN
Eukaryotic initiation factor 4A-I
EIF4A1
271Annotation score:
J3KS25J3KS25_HUMAN
Eukaryotic initiation factor 4A-I
EIF4A1
187Annotation score:
J3KSZ0J3KSZ0_HUMAN
Eukaryotic initiation factor 4A-I
EIF4A1
230Annotation score:
J3KTN0J3KTN0_HUMAN
Eukaryotic initiation factor 4A-I
EIF4A1
117Annotation score:
J3QLN6J3QLN6_HUMAN
Eukaryotic initiation factor 4A-I
EIF4A1
163Annotation score:
J3QR64J3QR64_HUMAN
Eukaryotic initiation factor 4A-I
EIF4A1
214Annotation score:
J3KS93J3KS93_HUMAN
Eukaryotic initiation factor 4A-I
EIF4A1
85Annotation score:
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei300Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC016876 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000578495; ENSP00000464550; ENSG00000161960
UCSCiuc060aqz.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC016876 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliJ3QS69
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiJ3QS69
PeptideAtlasiJ3QS69
PRIDEiJ3QS69

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000578495; ENSP00000464550; ENSG00000161960
UCSCiuc060aqz.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000161960.14
HGNCiHGNC:3282 EIF4A1
OpenTargetsiENSG00000161960
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0327 Eukaryota
COG0513 LUCA
GeneTreeiENSGT00530000062880

Miscellaneous databases

ChiTaRSiEIF4A1 human

Gene expression databases

BgeeiENSG00000161960 Expressed in 88 organ(s), highest expression level in left coronary artery
ExpressionAtlasiJ3QS69 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR037583 EIF4A
IPR014001 Helicase_ATP-bd
IPR027417 P-loop_NTPase
IPR000629 RNA-helicase_DEAD-box_CS
IPR014014 RNA_helicase_DEAD_Q_motif
PANTHERiPTHR24031:SF226 PTHR24031:SF226, 1 hit
PfamiView protein in Pfam
PF00270 DEAD, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS00039 DEAD_ATP_HELICASE, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51195 Q_MOTIF, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiJ3QS69_HUMAN
AccessioniPrimary (citable) accession number: J3QS69
Entry historyiIntegrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: October 3, 2012
Last modified: September 12, 2018
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again