UniProtKB - J3QRX8 (J3QRX8_HUMAN)
Protein
Submitted name:
Angiotensin-converting enzyme
Gene
ACE
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- metallopeptidase activity Source: InterPro
- peptidyl-dipeptidase activity Source: InterPro
Names & Taxonomyi
Protein namesi | Submitted name: Angiotensin-converting enzymeImported |
Gene namesi | Name:ACEImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:2707, ACE |
VEuPathDBi | HostDB:ENSG00000159640.15 |
Subcellular locationi
Other locations
- membrane Source: InterPro
Expressioni
Gene expression databases
Bgeei | ENSG00000159640, Expressed in small intestine and 138 other tissues |
ExpressionAtlasi | J3QRX8, baseline and differential |
Family & Domainsi
Sequence similaritiesi
Belongs to the peptidase M2 family.ARBA annotation
Phylogenomic databases
GeneTreei | ENSGT00940000162051 |
HOGENOMi | CLU_150223_0_0_1 |
Family and domain databases
CDDi | cd06461, M2_ACE, 1 hit |
InterProi | View protein in InterPro IPR001548, Peptidase_M2 |
PANTHERi | PTHR10514, PTHR10514, 1 hit |
Pfami | View protein in Pfam PF01401, Peptidase_M2, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All
J3QRX8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
XRTQGDFDPG AKFHIPSSVP YIRYFVSFII QFQFHEALCQ AAGHTGPLHK
60 70 80 90 100
CDIYQSKEAG QRLATAMKLG FSRPWPEAMQ LITGQPNMSA SAMLSYFKPL
110 120 130
LDWLRTENEL HGEKLGWPQY NWTPNSGTAT HPTSSLGS
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP12821 | ACE_HUMAN | Angiotensin-converting enzyme | ACE DCP, DCP1 | 1,306 | Annotation score: | ||
A0A0A0MSN4 | A0A0A0MSN4_HUMAN | Angiotensin-converting enzyme | ACE | 1,242 | Annotation score: | ||
J3KS28 | J3KS28_HUMAN | Angiotensin-converting enzyme | ACE | 314 | Annotation score: | ||
J3KTB8 | J3KTB8_HUMAN | Angiotensin-converting enzyme | ACE | 282 | Annotation score: | ||
J3KSQ5 | J3KSQ5_HUMAN | Angiotensin-converting enzyme | ACE | 208 | Annotation score: | ||
J3KRH5 | J3KRH5_HUMAN | Angiotensin-converting enzyme | ACE | 145 | Annotation score: | ||
J3KTH9 | J3KTH9_HUMAN | Angiotensin-converting enzyme | ACE | 168 | Annotation score: | ||
J3QLR4 | J3QLR4_HUMAN | Angiotensin-converting enzyme | ACE | 119 | Annotation score: | ||
J3QSC7 | J3QSC7_HUMAN | Angiotensin-converting enzyme | ACE | 36 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC113554 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000579409; ENSP00000464428; ENSG00000159640 |
UCSCi | uc060ioi.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC113554 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
Proteomic databases
PeptideAtlasi | J3QRX8 |
PRIDEi | J3QRX8 |
Protocols and materials databases
Antibodypediai | 31288, 832 antibodies |
Genome annotation databases
Ensembli | ENST00000579409; ENSP00000464428; ENSG00000159640 |
UCSCi | uc060ioi.1, human |
Organism-specific databases
HGNCi | HGNC:2707, ACE |
OpenTargetsi | ENSG00000159640 |
VEuPathDBi | HostDB:ENSG00000159640.15 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000162051 |
HOGENOMi | CLU_150223_0_0_1 |
Miscellaneous databases
ChiTaRSi | ACE, human |
Gene expression databases
Bgeei | ENSG00000159640, Expressed in small intestine and 138 other tissues |
ExpressionAtlasi | J3QRX8, baseline and differential |
Family and domain databases
CDDi | cd06461, M2_ACE, 1 hit |
InterProi | View protein in InterPro IPR001548, Peptidase_M2 |
PANTHERi | PTHR10514, PTHR10514, 1 hit |
Pfami | View protein in Pfam PF01401, Peptidase_M2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | J3QRX8_HUMAN | |
Accessioni | J3QRX8Primary (citable) accession number: J3QRX8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 3, 2012 |
Last sequence update: | October 3, 2012 | |
Last modified: | February 10, 2021 | |
This is version 40 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |