UniProtKB - J3QRX1 (J3QRX1_HUMAN)
Protein
Submitted name:
Receptor tyrosine-protein kinase erbB-2
Gene
ERBB2
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Submitted name: Receptor tyrosine-protein kinase erbB-2Imported |
Gene namesi | Name:ERBB2Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3430, ERBB2 |
VEuPathDBi | HostDB:ENSG00000141736.13 |
PTM / Processingi
Keywords - PTMi
GlycoproteinARBA annotationProteomic databases
PeptideAtlasi | J3QRX1 |
PRIDEi | J3QRX1 |
Expressioni
Gene expression databases
Bgeei | ENSG00000141736, Expressed in esophagus mucosa and 226 other tissues |
ExpressionAtlasi | J3QRX1, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2 – 85 | Furin-likeInterPro annotationAdd BLAST | 84 |
Phylogenomic databases
GeneTreei | ENSGT00940000158232 |
HOGENOMi | CLU_1614589_0_0_1 |
Family and domain databases
Gene3Di | 3.80.20.20, 1 hit |
InterProi | View protein in InterPro IPR006211, Furin-like_Cys-rich_dom IPR009030, Growth_fac_rcpt_cys_sf IPR036941, Rcpt_L-dom_sf |
Pfami | View protein in Pfam PF00757, Furin-like, 1 hit |
SUPFAMi | SSF57184, SSF57184, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All
J3QRX1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
XHSGICELHC PALVTYNTDT FESMPNPEGR YTFGASCVTA CPYNYLSTDV
60 70 80 90 100
GSCTLVCPLH NQEVTAEDGT QRCEKCSKPC ARVCYGLGME HLREVRAVTS
110 120 130 140 150
ANIQEFAGCK KIFGSLAFLP ESFDGVSLCQ QAGVQWYDLG SLQPLPPGFK
160
QFSCLSLLSS WDYRDP
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP04626 | ERBB2_HUMAN | Receptor tyrosine-protein kinase er... | ERBB2 HER2, MLN19, NEU, NGL | 1,255 | Annotation score: | ||
J3QLU9 | J3QLU9_HUMAN | Receptor protein-tyrosine kinase | ERBB2 | 1,055 | Annotation score: | ||
B4DTR1 | B4DTR1_HUMAN | Receptor tyrosine-protein kinase er... | ERBB2 | 979 | Annotation score: | ||
F5H1T4 | F5H1T4_HUMAN | Receptor protein-tyrosine kinase | ERBB2 | 603 | Annotation score: | ||
J3KTI5 | J3KTI5_HUMAN | Receptor tyrosine-protein kinase er... | ERBB2 | 251 | Annotation score: | ||
J3QRJ7 | J3QRJ7_HUMAN | Receptor tyrosine-protein kinase er... | ERBB2 | 177 | Annotation score: | ||
J3KRI9 | J3KRI9_HUMAN | Receptor tyrosine-protein kinase er... | ERBB2 | 96 | Annotation score: | ||
J3QL83 | J3QL83_HUMAN | Receptor tyrosine-protein kinase er... | ERBB2 | 90 | Annotation score: | ||
J3QLV2 | J3QLV2_HUMAN | Receptor tyrosine-protein kinase er... | ERBB2 | 102 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 | |
Non-terminal residuei | 166 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC079199 Genomic DNA No translation available. AC087491 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000578502; ENSP00000464420; ENSG00000141736 |
UCSCi | uc060etg.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC079199 Genomic DNA No translation available. AC087491 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
Proteomic databases
PeptideAtlasi | J3QRX1 |
PRIDEi | J3QRX1 |
Protocols and materials databases
Antibodypediai | 740, 5598 antibodies |
Genome annotation databases
Ensembli | ENST00000578502; ENSP00000464420; ENSG00000141736 |
UCSCi | uc060etg.1, human |
Organism-specific databases
HGNCi | HGNC:3430, ERBB2 |
OpenTargetsi | ENSG00000141736 |
VEuPathDBi | HostDB:ENSG00000141736.13 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000158232 |
HOGENOMi | CLU_1614589_0_0_1 |
Miscellaneous databases
ChiTaRSi | ERBB2, human |
Gene expression databases
Bgeei | ENSG00000141736, Expressed in esophagus mucosa and 226 other tissues |
ExpressionAtlasi | J3QRX1, baseline and differential |
Family and domain databases
Gene3Di | 3.80.20.20, 1 hit |
InterProi | View protein in InterPro IPR006211, Furin-like_Cys-rich_dom IPR009030, Growth_fac_rcpt_cys_sf IPR036941, Rcpt_L-dom_sf |
Pfami | View protein in Pfam PF00757, Furin-like, 1 hit |
SUPFAMi | SSF57184, SSF57184, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | J3QRX1_HUMAN | |
Accessioni | J3QRX1Primary (citable) accession number: J3QRX1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 3, 2012 |
Last sequence update: | October 3, 2012 | |
Last modified: | February 10, 2021 | |
This is version 45 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |