UniProtKB - J3QN06 (J3QN06_MOUSE)
Protein
ATP-dependent (S)-NAD(P)H-hydrate dehydratase
Gene
Naxd
Organism
Mus musculus (Mouse)
Status
Functioni
Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S-and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.UniRule annotation
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
Catalytic activityi
- EC:4.2.1.93UniRule annotation
Cofactori
Mg2+UniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 133 | NAD(P)HX; via amide nitrogenUniRule annotation | 1 |
GO - Molecular functioni
- ADP-dependent NAD(P)H-hydrate dehydratase activity Source: InterPro
- ATP binding Source: UniProtKB-KW
- ATP-dependent NAD(P)H-hydrate dehydratase activity Source: UniProtKB-UniRule
GO - Biological processi
- nicotinamide nucleotide metabolic process Source: UniProtKB-UniRule
Keywordsi
Molecular function | LyaseUniRule annotation |
Ligand | ATP-bindingUniRule annotation, NADUniRule annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: ATP-dependent (S)-NAD(P)H-hydrate dehydrataseUniRule annotation (EC:4.2.1.93UniRule annotation)Alternative name(s): ATP-dependent NAD(P)HX dehydrataseUniRule annotation Carbohydrate kinase domain-containing proteinUniRule annotation |
Gene namesi | |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1913353 Naxd |
Subcellular locationi
Mitochondrion
- Mitochondrion UniRule annotation
Mitochondrion
- mitochondrion Source: UniProtKB-SubCell
Keywords - Cellular componenti
MitochondrionUniRule annotationPTM / Processingi
Keywords - PTMi
PhosphoproteinUniRule annotationProteomic databases
jPOSTi | J3QN06 |
MaxQBi | J3QN06 |
PeptideAtlasi | J3QN06 |
PRIDEi | J3QN06 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000031505 Expressed in 270 organ(s), highest expression level in dorsal pancreas |
ExpressionAtlasi | J3QN06 baseline and differential |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 186 – 192 | NAD(P)HXUniRule annotation | 7 | |
Regioni | 242 – 272 | DisorderedSequence analysisAdd BLAST | 31 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 254 – 272 | PolarSequence analysisAdd BLAST | 19 |
Sequence similaritiesi
Belongs to the NnrD/CARKD family.UniRule annotation
Phylogenomic databases
GeneTreei | ENSGT00390000000917 |
OrthoDBi | 1337331at2759 |
Family and domain databases
CDDi | cd01171 YXKO-related, 1 hit |
Gene3Di | 3.40.1190.20, 1 hit |
HAMAPi | MF_01965 NADHX_dehydratase, 1 hit |
InterProi | View protein in InterPro IPR000631 CARKD IPR029056 Ribokinase-like |
Pfami | View protein in Pfam PF01256 Carb_kinase, 1 hit |
SUPFAMi | SSF53613 SSF53613, 1 hit |
TIGRFAMsi | TIGR00196 yjeF_cterm, 1 hit |
PROSITEi | View protein in PROSITE PS51383 YJEF_C_3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
J3QN06-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGVRCVAIRA CGGVLQRALS LHTAHATKDM ENLFQLVRNI VPALTSKKHK
60 70 80 90 100
GQDGRIGIVG GCQEYTGAPY FAGISALKVG ADLTHVFCAR EAAPVIKSYS
110 120 130 140 150
PELIVHPVLD SSNAVEEVEK WLPRLHALVV GPGLGRDDLL LNNVRGILES
160 170 180 190 200
TKARDIPVVI DADGLWLVAQ QPALIHSYHK AILTPNHVEF SRLWEAVLSS
210 220 230 240 250
PMDSNDLKGS TLKLSQALGN ITVVQKGEQD LISNGQQAPA HSWWLPGAPA
260 270
HSQGSVTGRP SRSTGALQPL PT
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9CZ42 | NNRD_MOUSE | ATP-dependent (S)-NAD(P)H-hydrate d... | Naxd Carkd | 343 | Annotation score: | ||
K3W4M4 | K3W4M4_MOUSE | ATP-dependent (S)-NAD(P)H-hydrate d... | Naxd CARKD | 365 | Annotation score: | ||
J3QMM7 | J3QMM7_MOUSE | ATP-dependent (S)-NAD(P)H-hydrate d... | Naxd 0710008K08Rik, CARKD, Carkd, mCG_17317 | 327 | Annotation score: | ||
J3QPU6 | J3QPU6_MOUSE | ATP-dependent (S)-NAD(P)H-hydrate d... | Naxd Carkd | 79 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC124475 Genomic DNA No translation available. |
RefSeqi | NP_001280590.1, NM_001293661.1 |
Genome annotation databases
Ensembli | ENSMUST00000178721; ENSMUSP00000136535; ENSMUSG00000031505 |
GeneIDi | 69225 |
UCSCi | uc057aki.1 mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC124475 Genomic DNA No translation available. |
RefSeqi | NP_001280590.1, NM_001293661.1 |
3D structure databases
SMRi | J3QN06 |
ModBasei | Search... |
Proteomic databases
jPOSTi | J3QN06 |
MaxQBi | J3QN06 |
PeptideAtlasi | J3QN06 |
PRIDEi | J3QN06 |
Genome annotation databases
Ensembli | ENSMUST00000178721; ENSMUSP00000136535; ENSMUSG00000031505 |
GeneIDi | 69225 |
UCSCi | uc057aki.1 mouse |
Organism-specific databases
CTDi | 55739 |
MGIi | MGI:1913353 Naxd |
Phylogenomic databases
GeneTreei | ENSGT00390000000917 |
OrthoDBi | 1337331at2759 |
Miscellaneous databases
ChiTaRSi | Carkd mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000031505 Expressed in 270 organ(s), highest expression level in dorsal pancreas |
ExpressionAtlasi | J3QN06 baseline and differential |
Family and domain databases
CDDi | cd01171 YXKO-related, 1 hit |
Gene3Di | 3.40.1190.20, 1 hit |
HAMAPi | MF_01965 NADHX_dehydratase, 1 hit |
InterProi | View protein in InterPro IPR000631 CARKD IPR029056 Ribokinase-like |
Pfami | View protein in Pfam PF01256 Carb_kinase, 1 hit |
SUPFAMi | SSF53613 SSF53613, 1 hit |
TIGRFAMsi | TIGR00196 yjeF_cterm, 1 hit |
PROSITEi | View protein in PROSITE PS51383 YJEF_C_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | J3QN06_MOUSE | |
Accessioni | J3QN06Primary (citable) accession number: J3QN06 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 3, 2012 |
Last sequence update: | October 3, 2012 | |
Last modified: | July 31, 2019 | |
This is version 51 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |