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Entry version 65 (12 Aug 2020)
Sequence version 1 (03 Oct 2012)
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Protein
Submitted name:

Calcium homeostasis endoplasmic reticulum protein

Gene

CHERP

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Calcium homeostasis endoplasmic reticulum proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CHERPImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000085872.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16930, CHERP

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000085872

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
J3QK89

MaxQB - The MaxQuant DataBase

More...
MaxQBi
J3QK89

PeptideAtlas

More...
PeptideAtlasi
J3QK89

PRoteomics IDEntifications database

More...
PRIDEi
J3QK89

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000085872, Expressed in female gonad and 240 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
J3QK89, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
J3QK89, 1 interactor

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini15 – 57SURP motifInterPro annotationAdd BLAST43
Domaini149 – 300CIDInterPro annotationAdd BLAST152
Domaini852 – 902G-patchInterPro annotationAdd BLAST51

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni347 – 560DisorderedSequence analysisAdd BLAST214
Regioni612 – 646DisorderedSequence analysisAdd BLAST35
Regioni733 – 889DisorderedSequence analysisAdd BLAST157

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili109 – 129Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi362 – 390Pro-richSequence analysisAdd BLAST29
Compositional biasi420 – 461Pro-richSequence analysisAdd BLAST42
Compositional biasi487 – 515PolarSequence analysisAdd BLAST29
Compositional biasi529 – 546Pro-richSequence analysisAdd BLAST18
Compositional biasi612 – 632Pro-richSequence analysisAdd BLAST21
Compositional biasi761 – 783PolarSequence analysisAdd BLAST23
Compositional biasi784 – 827BasicSequence analysisAdd BLAST44

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00730000111147

Identification of Orthologs from Complete Genome Data

More...
OMAi
CVISKLQ

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.790, 1 hit
1.25.40.90, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039037, CHERP
IPR006569, CID_dom
IPR008942, ENTH_VHS
IPR000467, G_patch_dom
IPR006903, RNA_pol_II-bd
IPR000061, Surp
IPR035967, SWAP/Surp_sf

The PANTHER Classification System

More...
PANTHERi
PTHR12323, PTHR12323, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04818, CTD_bind, 1 hit
PF01585, G-patch, 1 hit
PF01805, Surp, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00443, G_patch, 1 hit
SM00648, SWAP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109905, SSF109905, 1 hit
SSF48464, SSF48464, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51391, CID, 1 hit
PS50174, G_PATCH, 1 hit
PS50128, SURP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

J3QK89-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEMPLPPDDQ ELRNVIDKLA QFVARNGPEF EKMTMEKQKD NPKFSFLFGG
60 70 80 90 100
EFYSYYKCKL ALEQQQLICK QQTPELEPAA TMPPLPQPPL APAAPIPPAQ
110 120 130 140 150
GAPSMDELIQ QSQWNLQQQE QHLLALRQEQ VTAAVAHAVE QQMQKLLEET
160 170 180 190 200
QLDMNEFDNL LQPIIDTCTK DAISAGKNWM FSNAKSPPHC ELMAGHLRNR
210 220 230 240 250
ITADGAHFEL RLHLIYLIND VLHHWALTRG KSLPHSQRKQ ARELLAALQK
260 270 280 290 300
VVVPIYCTSF LAVEEDKQQK IARLLQLWEK NGYFDDSIIQ QLQSPALGLG
310 320 330 340 350
QYQATLINEY SSVVQPVQLA FQQQIQTLKT QHEEFVTSLA QQQQQQQQQQ
360 370 380 390 400
QQLQMPQMEA EVKATPPPPA PPPAPAPAPA IPPTTQPDDS KPPIQMPGSS
410 420 430 440 450
EYEAPGGVQD PAAAGPRGPG PHDQIPPNKP PWFDQPHPVA PWGQQQPPEQ
460 470 480 490 500
PPYPHHQGGP PHCPPWNNSH EGMWGEQRGD PGWNGQRDAP WNNQPDAAWN
510 520 530 540 550
SQFEGPWNSQ HEQPPWGGGQ REPPFRMQRP PHFRGPFPPH QQHPQFNQPP
560 570 580 590 600
HPHNFNRFPP RFMQDDFPPR HPFERPPYPH RFDYPQGDFP AEMGPPHHHP
610 620 630 640 650
GHRMPHPGIN EHPPWAGPQH PDFGPPPHGF NGQPPHMRRQ GPPHINHDDP
660 670 680 690 700
SLVPNVPYFD LPAGLMAPLV KLEDHEYKPL DPKDIRLPPP MPPSERLLAA
710 720 730 740 750
VEAFYSPPSH DRPRNSEGWE QNGLYEFFRA KMRARRRKGQ EKRNSGPSRS
760 770 780 790 800
RSRSKSRGRS SSRSNSRSSK SSGSYSRSRS RSCSRSYSRS RSRSRSRSRS
810 820 830 840 850
SRSRSRSQSR SRSKSYSPGR RRRSRSRSPT PPSSAGLGSN SAPPIPDSRL
860 870 880 890 900
GEENKGHQML VKMGWSGSGG LGAKEQGIQD PIKGGDVRDK WDQYKGVGVA
910 920
LDDPYENYRR NKSYSFIARM KARDECK
Length:927
Mass (Da):104,934
Last modified:October 3, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9F967660AB556D9A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8IWX8CHERP_HUMAN
Calcium homeostasis endoplasmic ret...
CHERP DAN26, SCAF6
916Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC008764 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000198939; ENSP00000198939; ENSG00000085872

UCSC genome browser

More...
UCSCi
uc060uzj.1, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008764 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiJ3QK89, 1 interactor

Proteomic databases

EPDiJ3QK89
MaxQBiJ3QK89
PeptideAtlasiJ3QK89
PRIDEiJ3QK89

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
27406, 204 antibodies

Genome annotation databases

EnsembliENST00000198939; ENSP00000198939; ENSG00000085872
UCSCiuc060uzj.1, human

Organism-specific databases

EuPathDBiHostDB:ENSG00000085872.14
HGNCiHGNC:16930, CHERP
OpenTargetsiENSG00000085872

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00730000111147
OMAiCVISKLQ

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CHERP, human

Gene expression databases

BgeeiENSG00000085872, Expressed in female gonad and 240 other tissues
ExpressionAtlasiJ3QK89, baseline and differential

Family and domain databases

Gene3Di1.10.10.790, 1 hit
1.25.40.90, 1 hit
InterProiView protein in InterPro
IPR039037, CHERP
IPR006569, CID_dom
IPR008942, ENTH_VHS
IPR000467, G_patch_dom
IPR006903, RNA_pol_II-bd
IPR000061, Surp
IPR035967, SWAP/Surp_sf
PANTHERiPTHR12323, PTHR12323, 1 hit
PfamiView protein in Pfam
PF04818, CTD_bind, 1 hit
PF01585, G-patch, 1 hit
PF01805, Surp, 1 hit
SMARTiView protein in SMART
SM00443, G_patch, 1 hit
SM00648, SWAP, 1 hit
SUPFAMiSSF109905, SSF109905, 1 hit
SSF48464, SSF48464, 1 hit
PROSITEiView protein in PROSITE
PS51391, CID, 1 hit
PS50174, G_PATCH, 1 hit
PS50128, SURP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiJ3QK89_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: J3QK89
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: October 3, 2012
Last modified: August 12, 2020
This is version 65 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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