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Protein
Submitted name:

Hypoxia up-regulated protein 1

Gene

HYOU1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Hypoxia up-regulated protein 1Imported
Gene namesi
Name:HYOU1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000149428.18
HGNCiHGNC:16931 HYOU1

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000149428

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 34Sequence analysisAdd BLAST34
ChainiPRO_501409859535 – 224Sequence analysisAdd BLAST190

Proteomic databases

MaxQBiJ3KTF1
PeptideAtlasiJ3KTF1
PRIDEiJ3KTF1

Expressioni

Gene expression databases

BgeeiENSG00000149428 Expressed in 230 organ(s), highest expression level in islet of Langerhans
ExpressionAtlasiJ3KTF1 baseline and differential

Structurei

3D structure databases

SMRiJ3KTF1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG0104 Eukaryota
COG0443 LUCA
GeneTreeiENSGT00390000016919

Family and domain databases

InterProiView protein in InterPro
IPR013126 Hsp_70_fam
PANTHERiPTHR19375 PTHR19375, 1 hit
PfamiView protein in Pfam
PF00012 HSP70, 1 hit
PRINTSiPR00301 HEATSHOCK70

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 12 potential isoforms that are computationally mapped.Show allAlign All

J3KTF1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADKVRRQRP RRRVCWALVA VLLADLLALS DTLAVMSVDL GSESMKVAIV
60 70 80 90 100
KPGVPMEIVL NKESRRKTPV IVTLKENERF FGDSAASMAI KNPKATLRYF
110 120 130 140 150
QHLLGKQADN PHVALYQARF PEHELTFDPQ RQTVHFQISS QLQFSPEEVL
160 170 180 190 200
GMVLNYSRSL AEDFAEQPIK DAVITVPVFF NQAERRAVLQ AARMAGLKVL
210 220
QLINDNTATA LSYGVFRRKD INTT
Length:224
Mass (Da):25,236
Last modified:October 3, 2012 - v1
Checksum:i830BE183A683F786
GO

Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9Y4L1HYOU1_HUMAN
Hypoxia up-regulated protein 1
HYOU1 GRP170, ORP150
999Annotation score:
E9PJ21E9PJ21_HUMAN
Hypoxia up-regulated protein 1
HYOU1
656Annotation score:
J3QL06J3QL06_HUMAN
Hypoxia up-regulated protein 1
HYOU1
211Annotation score:
K7EQK2K7EQK2_HUMAN
Hypoxia up-regulated protein 1
HYOU1
678Annotation score:
A0A087X054A0A087X054_HUMAN
Hypoxia up-regulated protein 1
HYOU1
937Annotation score:
A0A087WWI4A0A087WWI4_HUMAN
Hypoxia up-regulated protein 1
HYOU1
677Annotation score:
J3QQH7J3QQH7_HUMAN
Hypoxia up-regulated protein 1
HYOU1
149Annotation score:
J3QLE9J3QLE9_HUMAN
Hypoxia up-regulated protein 1
HYOU1
154Annotation score:
Q9BST8Q9BST8_HUMAN
HYOU1 protein
HYOU1
147Annotation score:
A0A087WW13A0A087WW13_HUMAN
Hypoxia up-regulated protein 1
HYOU1
102Annotation score:
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei224Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP003392 Genomic DNA No translation available.
KF510357 Genomic DNA No translation available.
KF511132 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000534233; ENSP00000462951; ENSG00000149428
ENST00000628974; ENSP00000486231; ENSG00000280682
UCSCiuc058iec.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP003392 Genomic DNA No translation available.
KF510357 Genomic DNA No translation available.
KF511132 Genomic DNA No translation available.

3D structure databases

SMRiJ3KTF1
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiJ3KTF1
PeptideAtlasiJ3KTF1
PRIDEiJ3KTF1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000534233; ENSP00000462951; ENSG00000149428
ENST00000628974; ENSP00000486231; ENSG00000280682
UCSCiuc058iec.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000149428.18
HGNCiHGNC:16931 HYOU1
OpenTargetsiENSG00000149428
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0104 Eukaryota
COG0443 LUCA
GeneTreeiENSGT00390000016919

Miscellaneous databases

ChiTaRSiHYOU1 human

Gene expression databases

BgeeiENSG00000149428 Expressed in 230 organ(s), highest expression level in islet of Langerhans
ExpressionAtlasiJ3KTF1 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR013126 Hsp_70_fam
PANTHERiPTHR19375 PTHR19375, 1 hit
PfamiView protein in Pfam
PF00012 HSP70, 1 hit
PRINTSiPR00301 HEATSHOCK70
ProtoNetiSearch...

Entry informationi

Entry nameiJ3KTF1_HUMAN
AccessioniPrimary (citable) accession number: J3KTF1
Entry historyiIntegrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: October 3, 2012
Last modified: September 12, 2018
This is version 45 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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