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Entry version 42 (07 Apr 2021)
Sequence version 2 (05 Dec 2018)
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Protein
Submitted name:

Peripheral-type benzodiazepine receptor-associated protein 1

Gene

TSPOAP1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Peripheral-type benzodiazepine receptor-associated protein 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TSPOAP1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16831, TSPOAP1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000005379.15

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000005379

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
J3KT64

PRoteomics IDEntifications database

More...
PRIDEi
J3KT64

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000005379, Expressed in right frontal lobe and 211 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
J3KT64, baseline and differential

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini16 – 108Fibronectin type-IIIInterPro annotationAdd BLAST93
Domaini113 – 213Fibronectin type-IIIInterPro annotationAdd BLAST101
Domaini757 – 825SH3InterPro annotationAdd BLAST69
Domaini887 – 954SH3InterPro annotationAdd BLAST68

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni215 – 443DisorderedSequence analysisAdd BLAST229
Regioni462 – 611DisorderedSequence analysisAdd BLAST150
Regioni633 – 733DisorderedSequence analysisAdd BLAST101
Regioni846 – 884DisorderedSequence analysisAdd BLAST39
Regioni946 – 980DisorderedSequence analysisAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi244 – 266Pro-richSequence analysisAdd BLAST23
Compositional biasi330 – 351PolarSequence analysisAdd BLAST22
Compositional biasi391 – 407AcidicSequence analysisAdd BLAST17
Compositional biasi411 – 428PolarSequence analysisAdd BLAST18
Compositional biasi543 – 559PolyampholyteSequence analysisAdd BLAST17
Compositional biasi686 – 702PolyampholyteSequence analysisAdd BLAST17
Compositional biasi965 – 980PolyampholyteSequence analysisAdd BLAST16

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RIMBP family.ARBA annotation

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

SH3 domainPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183203

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_061098_0_0_1

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063, FN3, 1 hit
cd12012, SH3_RIM-BP_2, 1 hit
cd12013, SH3_RIM-BP_3, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR013783, Ig-like_fold
IPR035753, RIM-BP_SH3_2
IPR035755, RIM-BP_SH3_3
IPR040325, RIMBP1/2/3
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain

The PANTHER Classification System

More...
PANTHERi
PTHR14234, PTHR14234, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07653, SH3_2, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00452, SH3DOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060, FN3, 2 hits
SM00326, SH3, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265, SSF49265, 1 hit
SSF50044, SSF50044, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853, FN3, 2 hits
PS50002, SH3, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

J3KT64-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
DPLRCCLAVG ARAGVVPSQL RVHRLTATSA EITWVPGNSN LAHAIYLNGE
60 70 80 90 100
ECPPASPSTY WATFCHLRPG TPYQAQVEAQ LPPQGPWEPG WERLEQRAAT
110 120 130 140 150
LQFTTLPAGP PDAPLDVQIE PGPSPGILII SWLPVTIDAA GTSNGVRVTG
160 170 180 190 200
YAIYADGQKI MEVASPTAGS VLVELSQLQL LQVCREVVVR TMSPHGESAD
210 220 230 240 250
SIPAPITPAL APASLPARVS CPSPHPSPEA RAPLASASPG PGDPSSPLQH
260 270 280 290 300
PAPLGTQEPP GAPPASPSRE MAKGSHEDPP APCSQEEAGA AVLGTSEERT
310 320 330 340 350
ASTSTLGEKD PGPAAPSLAK QEAEWTAGEA CPASSSTQGA RAQQAPNTEM
360 370 380 390 400
CQGGDPGSGL RPRAEKEDTA ELGVHLVNSL VDHGRNSDLS DIQEEEEEEE
410 420 430 440 450
EEEEEELGSR TCSFQKQVAG NSIRENGAKS QPDPFCETDS DEEILEQILE
460 470 480 490 500
LPLQQFCSKK LFSIPEEEEE EEEDEEEEKS GAGCSSRDPG PPEPALLGLG
510 520 530 540 550
CDSGQPRRPG QCPLSPESSR AGDCLEDMPG LVGGSSRRRG GGSPEKPPSR
560 570 580 590 600
RRPPDPREHC SRLLSNNGPQ ASGRLGPTRE RGGLPVIEGP RTGLEASGRG
610 620 630 640 650
RLGPSRRCSR GRALEPGLAS CLSPKCLEIS IEYDSEDEQE AGSGGISITS
660 670 680 690 700
SCYPGDGEAW GTATVGRPRG PPKANSGPKP YPRLPAWEKG EPERRGRSAT
710 720 730 740 750
GRAKEPLSRA TETGEARGQD GSGRRGPQKR GVRVLRPSTA ELVPARSPSE
760 770 780 790 800
TLAYQHLPVR IFVALFDYDP VSMSPNPDAG EEELPFREGQ ILKVFGDKDA
810 820 830 840 850
DGFYQGEGGG RTGYIPCNMV AEVAVDSPAG RQQLLQRGYL SPDILLEGSA
860 870 880 890 900
HTTGPPPKPR RSKKAESEGP AQPCPGPPKL VPSADLKAPH SMVAAFDYNP
910 920 930 940 950
QESSPNMDVE AELPFRAGDV ITVFGGMDDD GFYYGELNGQ RGLVPSNFLE
960 970 980
GPGPEAGGLD REPRTPQAES QRTRRRRVQC
Length:980
Mass (Da):103,859
Last modified:December 5, 2018 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC099FB135CDB1DA0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
O95153RIMB1_HUMAN
Peripheral-type benzodiazepine rece...
TSPOAP1 BZRAP1, KIAA0612, RBP1, RIMBP1
1,857Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KSY4J3KSY4_HUMAN
Peripheral-type benzodiazepine rece...
TSPOAP1
296Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DGN5A0A0C4DGN5_HUMAN
Peripheral-type benzodiazepine rece...
TSPOAP1
171Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC004687 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000580669; ENSP00000462822; ENSG00000005379

UCSC genome browser

More...
UCSCi
uc060hxq.1, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004687 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiJ3KT64
PRIDEiJ3KT64

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
18369, 24 antibodies

Genome annotation databases

EnsembliENST00000580669; ENSP00000462822; ENSG00000005379
UCSCiuc060hxq.1, human

Organism-specific databases

HGNCiHGNC:16831, TSPOAP1
OpenTargetsiENSG00000005379
VEuPathDBiHostDB:ENSG00000005379.15

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00950000183203
HOGENOMiCLU_061098_0_0_1

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TSPOAP1, human

Gene expression databases

BgeeiENSG00000005379, Expressed in right frontal lobe and 211 other tissues
ExpressionAtlasiJ3KT64, baseline and differential

Family and domain databases

CDDicd00063, FN3, 1 hit
cd12012, SH3_RIM-BP_2, 1 hit
cd12013, SH3_RIM-BP_3, 1 hit
Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR013783, Ig-like_fold
IPR035753, RIM-BP_SH3_2
IPR035755, RIM-BP_SH3_3
IPR040325, RIMBP1/2/3
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
PANTHERiPTHR14234, PTHR14234, 1 hit
PfamiView protein in Pfam
PF07653, SH3_2, 2 hits
PRINTSiPR00452, SH3DOMAIN
SMARTiView protein in SMART
SM00060, FN3, 2 hits
SM00326, SH3, 2 hits
SUPFAMiSSF49265, SSF49265, 1 hit
SSF50044, SSF50044, 2 hits
PROSITEiView protein in PROSITE
PS50853, FN3, 2 hits
PS50002, SH3, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiJ3KT64_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: J3KT64
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: December 5, 2018
Last modified: April 7, 2021
This is version 42 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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