UniProtKB - J3KSZ8 (J3KSZ8_HUMAN)
Protein
Submitted name:
Male-specific lethal 1 homolog
Gene
MSL1
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Submitted name: Male-specific lethal 1 homologImported |
Gene namesi | Name:MSL1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000188895.11 |
HGNCi | HGNC:27905, MSL1 |
Subcellular locationi
Nucleus
- MSL complex Source: InterPro
- nucleoplasm Source: HPA
Expressioni
Gene expression databases
Bgeei | ENSG00000188895, Expressed in ventricular zone and 242 other tissues |
ExpressionAtlasi | J3KSZ8, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 457 – 575 | PEHEInterPro annotationAdd BLAST | 119 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 127 | DisorderedSequence analysisAdd BLAST | 127 | |
Regioni | 147 – 217 | DisorderedSequence analysisAdd BLAST | 71 | |
Regioni | 272 – 420 | DisorderedSequence analysisAdd BLAST | 149 | |
Regioni | 438 – 459 | DisorderedSequence analysisAdd BLAST | 22 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 41 – 55 | PolyampholyteSequence analysisAdd BLAST | 15 | |
Compositional biasi | 167 – 185 | Pro-richSequence analysisAdd BLAST | 19 | |
Compositional biasi | 272 – 305 | PolyampholyteSequence analysisAdd BLAST | 34 | |
Compositional biasi | 332 – 364 | PolyampholyteSequence analysisAdd BLAST | 33 |
Phylogenomic databases
GeneTreei | ENSGT00390000018292 |
Family and domain databases
InterProi | View protein in InterPro IPR026711, Msl-1 IPR031840, MSL1_dimer IPR029332, PEHE_dom |
PANTHERi | PTHR21656, PTHR21656, 1 hit |
Pfami | View protein in Pfam PF16801, MSL1_dimer, 1 hit PF15275, PEHE, 1 hit |
SMARTi | View protein in SMART SM01300, PEHE, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
J3KSZ8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTMRSAVFKA AAAPAGGNPE QRLDYERAAA LGGPEDEPGA AEAHFLPRHR
60 70 80 90 100
KLKEPGPPLA SSQGGSPAPS PAGCGGKGRG LLLPAGAAPG QQEESWGGSV
110 120 130 140 150
PLPCPPPATK QAGIGGEPAA AGAGCSPRPK YQAVLPIQTG SLVAAAKEPT
160 170 180 190 200
PWAGDKGGAA SPAATASDPA GPPPLPLPGP PPLAPTATAG TLAASEGRWK
210 220 230 240 250
SMRKSPLGGG GGSGASSQAA CLKQILLLQL DLIEQQQQQL QAKEKEIEEL
260 270 280 290 300
KSERDTLLAR IERMERRMQL VKKDNEKERH KLFQGYETEE REETELSEKI
310 320 330 340 350
KLECQPELSE TSQTLPPKPF SCGRSGKGHK RKSPFGSTER KTPVKKLAPE
360 370 380 390 400
FSKVKTKTPK HSPIKEEPCG SLSETVCKRE LRSQETPEKP RSSVDTPPRL
410 420 430 440 450
STPQKGPSTH PKEKAFSSEI EDLPYLSTTE MYLCRWHQPP PSPLPLRESS
460 470 480 490 500
PKKEETVAIP SWRDHSVEPL RDPNPSDLLE NLDDSVFSKR HAKLELDEKR
510 520 530 540 550
RKRWDIQRIR EQRILQRLQL RMYKKKGIQE SEPEVTSFFP EPDDVESLMI
560 570 580 590
TPFLPVVAFG RPLPKLTPQN FELPWLDERS RCRLEIQKKQ TPHRTCRK
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ68DK7 | MSL1_HUMAN | Male-specific lethal 1 homolog | MSL1 MSL1L1 | 614 | Annotation score: | ||
J3QQY0 | J3QQY0_HUMAN | Male-specific lethal 1 homolog | MSL1 | 461 | Annotation score: | ||
J3KRQ4 | J3KRQ4_HUMAN | Male-specific lethal 1 homolog | MSL1 | 116 | Annotation score: | ||
J3KTC2 | J3KTC2_HUMAN | Male-specific lethal 1 homolog | MSL1 | 146 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC068669 Genomic DNA No translation available. |
RefSeqi | XP_005257356.3, XM_005257299.4 |
Genome annotation databases
Ensembli | ENST00000578648; ENSP00000462731; ENSG00000188895 |
UCSCi | uc060ewt.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC068669 Genomic DNA No translation available. |
RefSeqi | XP_005257356.3, XM_005257299.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | J3KSZ8, 1 interactor |
Proteomic databases
MaxQBi | J3KSZ8 |
PeptideAtlasi | J3KSZ8 |
PRIDEi | J3KSZ8 |
Protocols and materials databases
Antibodypediai | 7890, 87 antibodies |
Genome annotation databases
Ensembli | ENST00000578648; ENSP00000462731; ENSG00000188895 |
UCSCi | uc060ewt.1, human |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000188895.11 |
HGNCi | HGNC:27905, MSL1 |
OpenTargetsi | ENSG00000188895 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00390000018292 |
Miscellaneous databases
BioGRID-ORCSi | 339287, 127 hits in 848 CRISPR screens |
ChiTaRSi | MSL1, human |
GenomeRNAii | 339287 |
Gene expression databases
Bgeei | ENSG00000188895, Expressed in ventricular zone and 242 other tissues |
ExpressionAtlasi | J3KSZ8, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR026711, Msl-1 IPR031840, MSL1_dimer IPR029332, PEHE_dom |
PANTHERi | PTHR21656, PTHR21656, 1 hit |
Pfami | View protein in Pfam PF16801, MSL1_dimer, 1 hit PF15275, PEHE, 1 hit |
SMARTi | View protein in SMART SM01300, PEHE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | J3KSZ8_HUMAN | |
Accessioni | J3KSZ8Primary (citable) accession number: J3KSZ8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 3, 2012 |
Last sequence update: | October 3, 2012 | |
Last modified: | December 2, 2020 | |
This is version 65 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |