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Protein
Submitted name:

Calcium load-activated calcium channel

Gene

TMCO1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Calcium load-activated calcium channelImported
Gene namesi
Name:TMCO1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000143183.16
HGNCiHGNC:18188 TMCO1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei79 – 97HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000143183

PTM / Processingi

Proteomic databases

EPDiJ3KS45
MaxQBiJ3KS45
PeptideAtlasiJ3KS45
PRIDEiJ3KS45

Expressioni

Gene expression databases

BgeeiENSG00000143183 Expressed in 229 organ(s), highest expression level in testis
ExpressionAtlasiJ3KS45 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliJ3KS45
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili21 – 48Sequence analysisAdd BLAST28
Coiled coili50 – 77Sequence analysisAdd BLAST28

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3312 Eukaryota
ENOG410XR8B LUCA
GeneTreeiENSGT00390000002659

Family and domain databases

InterProiView protein in InterPro
IPR002809 EMC3/TMCO1
IPR008559 TMCO1
PANTHERiPTHR20917 PTHR20917, 1 hit
PfamiView protein in Pfam
PF01956 DUF106, 1 hit
PIRSFiPIRSF023322 DUF841_euk, 1 hit
SMARTiView protein in SMART
SM01415 DUF106, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

J3KS45-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MESIAEFSLV SGITWVLVYR TDKYKRLKAE VEKQSKKLEK KKETITESAG
60 70 80 90 100
RQQKKKIERQ EEKLKNNNRD LSMVRMKSMF AIGFCFTALM GMFNSIFDGR
110 120 130 140
VVAKLPFTPL SYIQGLSHRN LLGDDTTDCS FIFLYILCTM SIR
Length:143
Mass (Da):16,580
Last modified:October 3, 2012 - v1
Checksum:iB59ACBF3F42C61BD
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9UM00TMCO1_HUMAN
Calcium load-activated calcium chan...
TMCO1 TMCC4, PNAS-10, PNAS-136, UNQ151/PRO177
188Annotation score:
J9JIE6J9JIE6_HUMAN
Calcium load-activated calcium chan...
TMCO1 hCG_1766418
239Annotation score:
J3KTQ7J3KTQ7_HUMAN
Calcium load-activated calcium chan...
TMCO1 hCG_1766418
152Annotation score:
J3QQY2J3QQY2_HUMAN
Calcium load-activated calcium chan...
TMCO1 hCG_1766418
104Annotation score:
J3QRB3J3QRB3_HUMAN
Calcium load-activated calcium chan...
TMCO1
95Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei143Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL451074 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000481278; ENSP00000462300; ENSG00000143183
UCSCiuc057mzg.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL451074 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliJ3KS45
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

EPDiJ3KS45
MaxQBiJ3KS45
PeptideAtlasiJ3KS45
PRIDEiJ3KS45

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000481278; ENSP00000462300; ENSG00000143183
UCSCiuc057mzg.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000143183.16
HGNCiHGNC:18188 TMCO1
OpenTargetsiENSG00000143183
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3312 Eukaryota
ENOG410XR8B LUCA
GeneTreeiENSGT00390000002659

Miscellaneous databases

ChiTaRSiTMCO1 human

Gene expression databases

BgeeiENSG00000143183 Expressed in 229 organ(s), highest expression level in testis
ExpressionAtlasiJ3KS45 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR002809 EMC3/TMCO1
IPR008559 TMCO1
PANTHERiPTHR20917 PTHR20917, 1 hit
PfamiView protein in Pfam
PF01956 DUF106, 1 hit
PIRSFiPIRSF023322 DUF841_euk, 1 hit
SMARTiView protein in SMART
SM01415 DUF106, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiJ3KS45_HUMAN
AccessioniPrimary (citable) accession number: J3KS45
Entry historyiIntegrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: October 3, 2012
Last modified: September 12, 2018
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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