UniProtKB - J3KS28 (J3KS28_HUMAN)
Protein
Angiotensin-converting enzyme
Gene
ACE
Organism
Homo sapiens (Human)
Status
Functioni
Cofactori
Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation
GO - Molecular functioni
- carboxypeptidase activity Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
- metallopeptidase activity Source: UniProtKB-KW
- peptidyl-dipeptidase activity Source: InterPro
Keywordsi
Molecular function | CarboxypeptidaseUniRule annotation, Hydrolase, MetalloproteaseUniRule annotation, Protease |
Ligand | Metal-bindingUniRule annotation, ZincUniRule annotation |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:ACEImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:2707, ACE |
VEuPathDBi | HostDB:ENSG00000159640.15 |
Subcellular locationi
Other locations
- membrane Source: InterPro
PTM / Processingi
Keywords - PTMi
GlycoproteinUniRule annotationProteomic databases
PeptideAtlasi | J3KS28 |
PRIDEi | J3KS28 |
Expressioni
Gene expression databases
Bgeei | ENSG00000159640, Expressed in small intestine and 138 other tissues |
ExpressionAtlasi | J3KS28, baseline and differential |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 72 – 92 | Sequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000162051 |
HOGENOMi | CLU_887213_0_0_1 |
Family and domain databases
CDDi | cd06461, M2_ACE, 1 hit |
InterProi | View protein in InterPro IPR001548, Peptidase_M2 |
PANTHERi | PTHR10514, PTHR10514, 1 hit |
Pfami | View protein in Pfam PF01401, Peptidase_M2, 1 hit |
PRINTSi | PR00791, PEPDIPTASEA |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All
J3KS28-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDEGGCSQAA PAFAEGAGLG SGAPALSGSC LLTSGRCRCH RHRTALSIHP
60 70 80 90 100
PLARPLFWSQ FLLHHSHEAD SLQKEEARLP QTKEEAALLS QEFAEAWGQK
110 120 130 140 150
AKELYEPIWQ NFTDPQLRRI IGAVRTLGSA NLPLAKRQQY NALLSNMSRI
160 170 180 190 200
YSTAKVCLPN KTATCWSLDP DLTNILASSR SYAMLLFAWE GWHNAAGIPL
210 220 230 240 250
KPLYEDFTAL SNEAYKQDGF TDTGAYWRSW YNSPTFEDDL EHLYQQLEPL
260 270 280 290 300
YLNLHAFVRR ALHRRYGDRY INLRGPIPAH LLGDMWAQSW ENIYDMVVPF
310
PDKPNLDVTS TMLQ
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP12821 | ACE_HUMAN | Angiotensin-converting enzyme | ACE DCP, DCP1 | 1,306 | Annotation score: | ||
A0A0A0MSN4 | A0A0A0MSN4_HUMAN | Angiotensin-converting enzyme | ACE | 1,242 | Annotation score: | ||
J3KTB8 | J3KTB8_HUMAN | Angiotensin-converting enzyme | ACE | 282 | Annotation score: | ||
J3KSQ5 | J3KSQ5_HUMAN | Angiotensin-converting enzyme | ACE | 208 | Annotation score: | ||
J3KRH5 | J3KRH5_HUMAN | Angiotensin-converting enzyme | ACE | 145 | Annotation score: | ||
J3KTH9 | J3KTH9_HUMAN | Angiotensin-converting enzyme | ACE | 168 | Annotation score: | ||
J3QLR4 | J3QLR4_HUMAN | Angiotensin-converting enzyme | ACE | 119 | Annotation score: | ||
J3QRX8 | J3QRX8_HUMAN | Angiotensin-converting enzyme | ACE | 138 | Annotation score: | ||
J3QSC7 | J3QSC7_HUMAN | Angiotensin-converting enzyme | ACE | 36 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 314 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC113554 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000582627; ENSP00000462280; ENSG00000159640 |
UCSCi | uc060inu.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC113554 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | J3KS28 |
PRIDEi | J3KS28 |
Protocols and materials databases
Antibodypediai | 31288, 832 antibodies |
Genome annotation databases
Ensembli | ENST00000582627; ENSP00000462280; ENSG00000159640 |
UCSCi | uc060inu.1, human |
Organism-specific databases
HGNCi | HGNC:2707, ACE |
OpenTargetsi | ENSG00000159640 |
VEuPathDBi | HostDB:ENSG00000159640.15 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000162051 |
HOGENOMi | CLU_887213_0_0_1 |
Miscellaneous databases
ChiTaRSi | ACE, human |
Gene expression databases
Bgeei | ENSG00000159640, Expressed in small intestine and 138 other tissues |
ExpressionAtlasi | J3KS28, baseline and differential |
Family and domain databases
CDDi | cd06461, M2_ACE, 1 hit |
InterProi | View protein in InterPro IPR001548, Peptidase_M2 |
PANTHERi | PTHR10514, PTHR10514, 1 hit |
Pfami | View protein in Pfam PF01401, Peptidase_M2, 1 hit |
PRINTSi | PR00791, PEPDIPTASEA |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | J3KS28_HUMAN | |
Accessioni | J3KS28Primary (citable) accession number: J3KS28 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 3, 2012 |
Last sequence update: | October 3, 2012 | |
Last modified: | February 10, 2021 | |
This is version 52 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |