UniProtKB - J3KRM4 (J3KRM4_HUMAN)
Protein
Submitted name:
Aquaporin-4
Gene
AQP4
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- channel activity Source: InterPro
Keywordsi
Biological process | TransportUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Aquaporin-4Imported |
Gene namesi | Name:AQP4Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:637, AQP4 |
VEuPathDBi | HostDB:ENSG00000171885.13 |
Subcellular locationi
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 75 – 95 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 115 – 135 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 147 – 166 | HelicalSequence analysisAdd BLAST | 20 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSG00000171885, Expressed in lateral globus pallidus and 172 other tissues |
ExpressionAtlasi | J3KRM4, baseline and differential |
Family & Domainsi
Sequence similaritiesi
Belongs to the MIP/aquaporin (TC 1.A.8) family. [View classification]UniRule annotationARBA annotation
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000156037 |
HOGENOMi | CLU_020019_3_3_1 |
Family and domain databases
Gene3Di | 1.20.1080.10, 1 hit |
InterProi | View protein in InterPro IPR023271, Aquaporin-like IPR034294, Aquaporin_transptr IPR000425, MIP IPR022357, MIP_CS |
PANTHERi | PTHR19139, PTHR19139, 1 hit |
Pfami | View protein in Pfam PF00230, MIP, 1 hit |
PRINTSi | PR00783, MINTRINSICP |
SUPFAMi | SSF81338, SSF81338, 1 hit |
PROSITEi | View protein in PROSITE PS00221, MIP, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
J3KRM4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSDRPTARRW GLGSTINWGG TEKPLPVDMV LISLCFGLSI ATMVQCFGHI
60 70 80 90 100
SGGHINPAVT VAMVCTRKIS IAKSVFYIAA QCLGAIIGAG ILYLVTPPSV
110 120 130 140 150
VGGLGVTMVH GNLTAGHGLL VELIITFQLV FTIFASCDSK RTDVTGSIAL
160 170 180
AIGFSVAIGH LFAINYTGAS MNPARSFGPA VIMGN
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP55087 | AQP4_HUMAN | Aquaporin-4 | AQP4 | 323 | Annotation score: | ||
A0A5F9ZHR4 | A0A5F9ZHR4_HUMAN | Aquaporin-4 | AQP4 | 352 | Annotation score: | ||
V9PBN7 | V9PBN7_HUMAN | Aquaporin 4 isoform delta4 | AQP4 | 296 | Annotation score: | ||
H0Y3H5 | H0Y3H5_HUMAN | Aquaporin-4 | AQP4 | 98 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 185 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC018371 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000578776; ENSP00000462075; ENSG00000171885 |
UCSCi | uc060oef.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC018371 Genomic DNA No translation available. |
3D structure databases
SMRi | J3KRM4 |
ModBasei | Search... |
Proteomic databases
PeptideAtlasi | J3KRM4 |
Protocols and materials databases
Antibodypediai | 3103, 560 antibodies |
Genome annotation databases
Ensembli | ENST00000578776; ENSP00000462075; ENSG00000171885 |
UCSCi | uc060oef.1, human |
Organism-specific databases
HGNCi | HGNC:637, AQP4 |
OpenTargetsi | ENSG00000171885 |
VEuPathDBi | HostDB:ENSG00000171885.13 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000156037 |
HOGENOMi | CLU_020019_3_3_1 |
Miscellaneous databases
ChiTaRSi | AQP4, human |
Gene expression databases
Bgeei | ENSG00000171885, Expressed in lateral globus pallidus and 172 other tissues |
ExpressionAtlasi | J3KRM4, baseline and differential |
Family and domain databases
Gene3Di | 1.20.1080.10, 1 hit |
InterProi | View protein in InterPro IPR023271, Aquaporin-like IPR034294, Aquaporin_transptr IPR000425, MIP IPR022357, MIP_CS |
PANTHERi | PTHR19139, PTHR19139, 1 hit |
Pfami | View protein in Pfam PF00230, MIP, 1 hit |
PRINTSi | PR00783, MINTRINSICP |
SUPFAMi | SSF81338, SSF81338, 1 hit |
PROSITEi | View protein in PROSITE PS00221, MIP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | J3KRM4_HUMAN | |
Accessioni | J3KRM4Primary (citable) accession number: J3KRM4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 3, 2012 |
Last sequence update: | October 3, 2012 | |
Last modified: | April 7, 2021 | |
This is version 48 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |