UniProtKB - J3KRH5 (J3KRH5_HUMAN)
Protein
Submitted name:
Angiotensin-converting enzyme
Gene
ACE
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- metallopeptidase activity Source: InterPro
- peptidyl-dipeptidase activity Source: InterPro
Names & Taxonomyi
Protein namesi | Submitted name: Angiotensin-converting enzymeImported |
Gene namesi | Name:ACEImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:2707, ACE |
VEuPathDBi | HostDB:ENSG00000159640.15 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
ChainiPRO_5003772081 | 22 – 145 | Sequence analysisAdd BLAST | 124 |
Proteomic databases
PeptideAtlasi | J3KRH5 |
PRIDEi | J3KRH5 |
Expressioni
Gene expression databases
Bgeei | ENSG00000159640, Expressed in small intestine and 138 other tissues |
ExpressionAtlasi | J3KRH5, baseline and differential |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 36 – 67 | DisorderedSequence analysisAdd BLAST | 32 |
Sequence similaritiesi
Belongs to the peptidase M2 family.ARBA annotation
Keywords - Domaini
SignalSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000162051 |
HOGENOMi | CLU_1786248_0_0_1 |
Family and domain databases
InterProi | View protein in InterPro IPR001548, Peptidase_M2 |
PANTHERi | PTHR10514, PTHR10514, 1 hit |
Pfami | View protein in Pfam PF01401, Peptidase_M2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All
J3KRH5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGQGWATAGL PSLLFLLLCY GHPLLVPSQE ASQQVTVTHG TSSQATTSSQ
60 70 80 90 100
TTTHQATAHQ TSAQSPNLVT DEAEASKFVE EYDRTSQVVW NEYAEANWNY
110 120 130 140
NTNITTETSK ILGLYDTWGS SLLCPCLDMC CLTAGIQGGC RRTCK
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP12821 | ACE_HUMAN | Angiotensin-converting enzyme | ACE DCP, DCP1 | 1,306 | Annotation score: | ||
A0A0A0MSN4 | A0A0A0MSN4_HUMAN | Angiotensin-converting enzyme | ACE | 1,242 | Annotation score: | ||
J3KS28 | J3KS28_HUMAN | Angiotensin-converting enzyme | ACE | 314 | Annotation score: | ||
J3KTB8 | J3KTB8_HUMAN | Angiotensin-converting enzyme | ACE | 282 | Annotation score: | ||
J3KSQ5 | J3KSQ5_HUMAN | Angiotensin-converting enzyme | ACE | 208 | Annotation score: | ||
J3KTH9 | J3KTH9_HUMAN | Angiotensin-converting enzyme | ACE | 168 | Annotation score: | ||
J3QLR4 | J3QLR4_HUMAN | Angiotensin-converting enzyme | ACE | 119 | Annotation score: | ||
J3QSC7 | J3QSC7_HUMAN | Angiotensin-converting enzyme | ACE | 36 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC113554 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000582005; ENSP00000462002; ENSG00000159640 |
UCSCi | uc060inz.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC113554 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | J3KRH5 |
PRIDEi | J3KRH5 |
Genome annotation databases
Ensembli | ENST00000582005; ENSP00000462002; ENSG00000159640 |
UCSCi | uc060inz.1, human |
Organism-specific databases
HGNCi | HGNC:2707, ACE |
OpenTargetsi | ENSG00000159640 |
VEuPathDBi | HostDB:ENSG00000159640.15 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000162051 |
HOGENOMi | CLU_1786248_0_0_1 |
Miscellaneous databases
ChiTaRSi | ACE, human |
Gene expression databases
Bgeei | ENSG00000159640, Expressed in small intestine and 138 other tissues |
ExpressionAtlasi | J3KRH5, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR001548, Peptidase_M2 |
PANTHERi | PTHR10514, PTHR10514, 1 hit |
Pfami | View protein in Pfam PF01401, Peptidase_M2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | J3KRH5_HUMAN | |
Accessioni | J3KRH5Primary (citable) accession number: J3KRH5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 3, 2012 |
Last sequence update: | October 3, 2012 | |
Last modified: | April 7, 2021 | |
This is version 44 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |