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Protein
Submitted name:

Ephrin type-B receptor 6

Gene

EPHB6

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionReceptorSAAS annotation
LigandATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Ephrin type-B receptor 6Imported
Gene namesi
Name:EPHB6Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000106123.11
HGNCiHGNC:3396 EPHB6

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei303 – 327HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000106123

PTM / Processingi

Proteomic databases

PeptideAtlasiJ3KQU5
PRIDEiJ3KQU5

Expressioni

Gene expression databases

BgeeiENSG00000106123
ExpressionAtlasiJ3KQU5 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliJ3KQU5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini77 – 194Fibronectin type-IIIInterPro annotationAdd BLAST118
Domaini195 – 290Fibronectin type-IIIInterPro annotationAdd BLAST96
Domaini378 – 627Protein kinaseInterPro annotationAdd BLAST250
Domaini664 – 720SAMInterPro annotationAdd BLAST57

Keywords - Domaini

RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG0196 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00760000118975

Family and domain databases

CDDicd00063 FN3, 2 hits
Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR027936 Eph_TM
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR009030 Growth_fac_rcpt_cys_sf
IPR013783 Ig-like_fold
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR011641 Tyr-kin_ephrin_A/B_rcpt-like
PfamiView protein in Pfam
PF14575 EphA2_TM, 1 hit
PF07699 Ephrin_rec_like, 1 hit
PF00041 fn3, 2 hits
PF07714 Pkinase_Tyr, 1 hit
PF07647 SAM_2, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM01411 Ephrin_rec_like, 1 hit
SM00060 FN3, 2 hits
SM00454 SAM, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
SSF49265 SSF49265, 1 hit
SSF56112 SSF56112, 1 hit
SSF57184 SSF57184, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 2 hits
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS50105 SAM_DOMAIN, 1 hit

Sequencei

Sequence statusi: Complete.

J3KQU5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVAVGGCRCQ PGYQPARGDK ACQACPRGLY KASAGNAPCS PCPARSHAPN
60 70 80 90 100
PAAPVCPCLE GFYRASSDPP EAPCTGPPSA PQELWFEVQG SALMLHWRLP
110 120 130 140 150
RELGGRGDLL FNVVCKECEG RQEPASGGGG TCHRCRDEVH FDPRQRGLTE
160 170 180 190 200
SRVLVGGLRA HVPYILEVQA VNGVSELSPD PPQAAAINVS TSHEVPSAVP
210 220 230 240 250
VVHQVSRASN SITVSWPQPD QTNGNILDYQ LRYYDQAEDE SHSFTLTSET
260 270 280 290 300
NTATVTQLSP GHIYGFQVRA RTAAGHGPYG GKVYFQTLPQ GELSSQLPER
310 320 330 340 350
LSLVIGSILG ALAFLLLAAI TVLAVVFQRK RRGTGYTEQL QQYSSPGLGV
360 370 380 390 400
KYYIDPSTYE DPCQAIRELA REVDPAYIKI EEVIGTGSFG EVRQGRLQPR
410 420 430 440 450
GRREQTVAIQ ALWAGGAESL QMTFLGRAAV LGQFQHPNIL RLEGVVTKSR
460 470 480 490 500
PLMVLTEFME LGPLDSFLRQ REGQFSSLQL VAMQRGVAAA MQYLSSFAFV
510 520 530 540 550
HRSLSAHSVL VNSHLVCKVA RLGHSPQGPS CLLRWAAPEV IAHGKHTTSS
560 570 580 590 600
DVWSFGILMW EVMSYGERPY WDMSEQEVLN AIEQEFRLPP PPGCPPGLHL
610 620 630 640 650
LMLDTWQKDR ARRPHFDQLV AAFDKMIRKP DTLQAGGDPG ERPSQALLTP
660 670 680 690 700
VALDFPCLDS PQAWLSAIGL ECYQDNFSKF GLCTFSDVAQ LSLEDLPALG
710 720
ITLAGHQKKL LHHIQLLQQH LRQQGSVEV
Length:729
Mass (Da):79,768
Last modified:October 29, 2014 - v2
Checksum:i9A6BD391485CDDA0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC245427 Genomic DNA No translation available.
RefSeqiNP_001267723.2, NM_001280794.2
NP_001267724.2, NM_001280795.2
UniGeneiHs.380089

Genome annotation databases

EnsembliENST00000411471; ENSP00000409061; ENSG00000106123
GeneIDi2051
UCSCiuc033anu.2 human

Similar proteinsi

Entry informationi

Entry nameiJ3KQU5_HUMAN
AccessioniPrimary (citable) accession number: J3KQU5
Entry historyiIntegrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: October 29, 2014
Last modified: July 18, 2018
This is version 54 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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