UniProtKB - J3KQH6 (J3KQH6_HUMAN)
Protein
Submitted name:
Polyhomeotic-like protein 1
Gene
PHC1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- zinc ion binding Source: InterPro
Keywordsi
Molecular function | DNA-bindingARBA annotation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Submitted name: Polyhomeotic-like protein 1Imported |
Gene namesi | Name:PHC1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000111752.10 |
HGNCi | HGNC:3182, PHC1 |
Subcellular locationi
Nucleus
- Nucleus ARBA annotation
Nucleus
- nucleoplasm Source: HPA
Keywords - Cellular componenti
NucleusARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000111752, Expressed in pituitary gland and 212 other tissues |
ExpressionAtlasi | J3KQH6, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 746 – 780 | FCS-typeInterPro annotationAdd BLAST | 35 | |
Domaini | 895 – 959 | SAMInterPro annotationAdd BLAST | 65 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 62 | DisorderedSequence analysisAdd BLAST | 62 | |
Regioni | 167 – 196 | DisorderedSequence analysisAdd BLAST | 30 | |
Regioni | 216 – 310 | DisorderedSequence analysisAdd BLAST | 95 | |
Regioni | 387 – 456 | DisorderedSequence analysisAdd BLAST | 70 | |
Regioni | 511 – 543 | DisorderedSequence analysisAdd BLAST | 33 | |
Regioni | 591 – 627 | DisorderedSequence analysisAdd BLAST | 37 | |
Regioni | 803 – 883 | DisorderedSequence analysisAdd BLAST | 81 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 270 – 287 | PolarSequence analysisAdd BLAST | 18 | |
Compositional biasi | 387 – 401 | PolarSequence analysisAdd BLAST | 15 | |
Compositional biasi | 414 – 436 | PolarSequence analysisAdd BLAST | 23 | |
Compositional biasi | 440 – 456 | Pro-richSequence analysisAdd BLAST | 17 | |
Compositional biasi | 512 – 537 | PolarSequence analysisAdd BLAST | 26 | |
Compositional biasi | 594 – 608 | PolyampholyteSequence analysisAdd BLAST | 15 | |
Compositional biasi | 803 – 818 | PolyampholyteSequence analysisAdd BLAST | 16 | |
Compositional biasi | 824 – 841 | PolyampholyteSequence analysisAdd BLAST | 18 |
Keywords - Domaini
Zinc-fingerPROSITE-ProRule annotationARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000156612 |
Family and domain databases
Gene3Di | 1.10.150.50, 1 hit 3.30.60.160, 1 hit |
InterProi | View protein in InterPro IPR001660, SAM IPR013761, SAM/pointed_sf IPR012313, Znf_FCS IPR038603, Znf_FCS_sf |
Pfami | View protein in Pfam PF00536, SAM_1, 1 hit |
SMARTi | View protein in SMART SM00454, SAM, 1 hit |
SUPFAMi | SSF47769, SSF47769, 1 hit |
PROSITEi | View protein in PROSITE PS50105, SAM_DOMAIN, 1 hit PS51024, ZF_FCS, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All
J3KQH6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
METESEQNSN STNGSSSSGG SSRPQIAQMS LYERQAVQAT IAASRQASSP
60 70 80 90 100
NTSTTQQQTT TTQASINLAT TSAAQLISRS QSVSSPSATT LTQSVLLGNT
110 120 130 140 150
TSPPLNQSQA QMYLRVNRTL GRNVPLASQL ILMPNGAVAA VQQEVPSAQS
160 170 180 190 200
PGVHADADQV QNLAVRNQQA SAQGPQMQGS TQKAIPPGAS PVSSLSQASS
210 220 230 240 250
QALAVAQASS GATNQSLNLS QAGGGSGNSI PGSMGPGGGG QAHGGLGQLP
260 270 280 290 300
SSGMGGGSCP RKGTGVVQPL PAAQTVTVSQ GSQTEAESAA AKKAEADGSG
310 320 330 340 350
QQNVGMNLTR TATPAPSQTL ISSATYTQIQ PHSLIQQQQQ IHLQQKQVVI
360 370 380 390 400
QQQIAIHHQQ QFQHRQSQLL HTATHLQLAQ QQQQQQQQQQ QQQQPQATTL
410 420 430 440 450
TAPQPPQVPP TQQVPPSQSQ QQAQTLVVQP MLQSSPLSLP PDAAPKPPIP
460 470 480 490 500
IQSKPPVAPI KPPQLGAAKM SAAQQPPPHI PVQVVGTRQP GTAQAQALGL
510 520 530 540 550
AQLAAAVPTS RGMPGTVQSG QAHLASSPPS SQAPGALQEC PPTLAPGMTL
560 570 580 590 600
APVQGTAHVV KGGATTSSPV VAQVPAAFYM QSVHLPGKPQ TLAVKRKADS
610 620 630 640 650
EEERDDVSTL GSMLPAKASP VAESPKVMDE KSSLGEKAES VANVNANTPS
660 670 680 690 700
SELVALTPAP SVPPPTLAMV SRQMGDSKPP QAIVKPQILT HIIEGFVIQE
710 720 730 740 750
GAEPFPVGCS QLLKESEKPL QTGLPTGLTE NQSGGPLGVD SPSAELDKKA
760 770 780 790 800
NLLKCEYCGK YAPAEQFRGS KRFCSMTCAK RYNVSCSHQF RLKRKKMKEF
810 820 830 840 850
QEANYARVRR RGPRRSSSDI ARAKIQGKCH RGQEDSSRGS DNSSYDEALS
860 870 880 890 900
PTSPGPLSVR AGHGERDLGN PNTAPPTPEL HGINPVFLSS NPSRWSVEEV
910 920 930 940 950
YEFIASLQGC QEIAEEFRSQ EIDGQALLLL KEEHLMSAMN IKLGPALKIC
AKINVLKET
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP78364 | PHC1_HUMAN | Polyhomeotic-like protein 1 | PHC1 EDR1, PH1 | 1,004 | Annotation score: | ||
F5H0T9 | F5H0T9_HUMAN | Polyhomeotic-like protein 1 | PHC1 | 158 | Annotation score: | ||
H0YGK7 | H0YGK7_HUMAN | Polyhomeotic-like protein 1 | PHC1 | 187 | Annotation score: | ||
H0YH74 | H0YH74_HUMAN | Polyhomeotic-like protein 1 | PHC1 | 99 | Annotation score: | ||
H0YGZ1 | H0YGZ1_HUMAN | Polyhomeotic-like protein 1 | PHC1 | 131 | Annotation score: | ||
F5H6P9 | F5H6P9_HUMAN | Polyhomeotic-like protein 1 | PHC1 | 182 | Annotation score: | ||
F5H6F5 | F5H6F5_HUMAN | Polyhomeotic-like protein 1 | PHC1 | 171 | Annotation score: | ||
F5H6F9 | F5H6F9_HUMAN | Polyhomeotic-like protein 1 | PHC1 | 179 | Annotation score: | ||
F5GZP4 | F5GZP4_HUMAN | Polyhomeotic-like protein 1 | PHC1 | 184 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC006581 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000433083; ENSP00000399194; ENSG00000111752 |
UCSCi | uc058kyl.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC006581 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | J3KQH6, 1 interactor |
Proteomic databases
MaxQBi | J3KQH6 |
PeptideAtlasi | J3KQH6 |
PRIDEi | J3KQH6 |
Protocols and materials databases
Antibodypediai | 1884, 193 antibodies |
Genome annotation databases
Ensembli | ENST00000433083; ENSP00000399194; ENSG00000111752 |
UCSCi | uc058kyl.1, human |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000111752.10 |
HGNCi | HGNC:3182, PHC1 |
OpenTargetsi | ENSG00000111752 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000156612 |
Miscellaneous databases
ChiTaRSi | PHC1, human |
Gene expression databases
Bgeei | ENSG00000111752, Expressed in pituitary gland and 212 other tissues |
ExpressionAtlasi | J3KQH6, baseline and differential |
Family and domain databases
Gene3Di | 1.10.150.50, 1 hit 3.30.60.160, 1 hit |
InterProi | View protein in InterPro IPR001660, SAM IPR013761, SAM/pointed_sf IPR012313, Znf_FCS IPR038603, Znf_FCS_sf |
Pfami | View protein in Pfam PF00536, SAM_1, 1 hit |
SMARTi | View protein in SMART SM00454, SAM, 1 hit |
SUPFAMi | SSF47769, SSF47769, 1 hit |
PROSITEi | View protein in PROSITE PS50105, SAM_DOMAIN, 1 hit PS51024, ZF_FCS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | J3KQH6_HUMAN | |
Accessioni | J3KQH6Primary (citable) accession number: J3KQH6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 3, 2012 |
Last sequence update: | October 3, 2012 | |
Last modified: | December 2, 2020 | |
This is version 66 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |