UniProtKB - J3KQ32 (J3KQ32_HUMAN)
Protein
Obg-like ATPase 1
Gene
OLA1
Organism
Homo sapiens (Human)
Status
Functioni
Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.UniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 251 | ATP; via carbonyl oxygenUniRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 52 – 57 | ATPUniRule annotation | 6 |
GO - Molecular functioni
- ATPase activity Source: UniProtKB-UniRule
- ATP binding Source: UniProtKB-UniRule
- GTP binding Source: InterPro
- ribosomal large subunit binding Source: UniProtKB-UniRule
- ribosome binding Source: UniProtKB-UniRule
Keywordsi
Molecular function | HydrolaseUniRule annotation |
Ligand | ATP-bindingUniRule annotationARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Obg-like ATPase 1UniRule annotation |
Gene namesi | |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:28833, OLA1 |
VEuPathDBi | HostDB:ENSG00000138430.15 |
Subcellular locationi
Cytoskeleton
- centrosome Source: HPA
Cytosol
- cytosol Source: HPA
Nucleus
- nucleolus Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmUniRule annotation, NucleusUniRule annotationExpressioni
Gene expression databases
Bgeei | ENSG00000138430, Expressed in cervix squamous epithelium and 246 other tissues |
ExpressionAtlasi | J3KQ32, baseline and differential |
Interactioni
Subunit structurei
Monomer.
UniRule annotationProtein-protein interaction databases
IntActi | J3KQ32, 1 interactor |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 43 – 303 | OBG-type GInterPro annotationAdd BLAST | 261 | |
Domaini | 324 – 407 | TGSInterPro annotationAdd BLAST | 84 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 28 | DisorderedSequence analysisAdd BLAST | 28 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 287 – 294 | Nuclear export signalUniRule annotation | 8 |
Sequence similaritiesi
Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.UniRule annotation
Phylogenomic databases
GeneTreei | ENSGT00390000000673 |
OMAi | VLRCFDN |
PhylomeDBi | J3KQ32 |
Family and domain databases
CDDi | cd04867, TGS_YchF_OLA1, 1 hit cd01900, YchF, 1 hit |
Gene3Di | 1.10.150.300, 1 hit 3.10.20.30, 1 hit |
HAMAPi | MF_00944, YchF_OLA1_ATPase, 1 hit |
InterProi | View protein in InterPro IPR004396, ATPase_YchF/OLA1 IPR012675, Beta-grasp_dom_sf IPR031167, G_OBG IPR006073, GTP-bd IPR027417, P-loop_NTPase IPR004095, TGS IPR012676, TGS-like IPR023192, TGS-like_dom_sf IPR013029, YchF_C IPR041706, YchF_N |
Pfami | View protein in Pfam PF01926, MMR_HSR1, 1 hit PF06071, YchF-GTPase_C, 1 hit |
PIRSFi | PIRSF006641, CHP00092, 1 hit |
PRINTSi | PR00326, GTP1OBG |
SUPFAMi | SSF52540, SSF52540, 1 hit SSF81271, SSF81271, 1 hit |
TIGRFAMsi | TIGR00092, TIGR00092, 1 hit |
PROSITEi | View protein in PROSITE PS51710, G_OBG, 1 hit PS51880, TGS, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
J3KQ32-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSRTFSAKGG RDLVEGPQYL MPPKKGGDGI KPPPIIGRFG TSLKIGIVGL
60 70 80 90 100
PNVGKSTFFN VLTNSQASAE NFPFCTIDPN ESRVPVPDER FDFLCQYHKP
110 120 130 140 150
ASKIPAFLNV VDIAGLVKGA HNGQGLGNAF LSHISACDGI FHLTRAFEDD
160 170 180 190 200
DITHVEGSVD PIRDIEIIHE ELQLKDEEMI GPIIDKLEKV AVRGGDKKLK
210 220 230 240 250
PEYDIMCKVK SWVIDQKKPV RFYHDWNDKE IEVLNKHLFL TSKPMVYLVN
260 270 280 290 300
LSEKDYIRKK NKWLIKIKEW VDKYDPGALV IPFSGALELK LQELSAEERQ
310 320 330 340 350
KYLEANMTQS ALPKIIKAGF AALQLEYFFT AGPDEVRAWT IRKGTKAPQA
360 370 380 390 400
AGKIHTDFEK GFIMAEVMKY EDFKEEGSEN AVKAAGKYRQ QGRNYIVEDG
410
DIIFFKFNTP QQPKKK
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9NTK5 | OLA1_HUMAN | Obg-like ATPase 1 | OLA1 GTPBP9, PRO2455, PTD004 | 396 | Annotation score: | ||
C9JTK6 | C9JTK6_HUMAN | Obg-like ATPase 1 | OLA1 | 116 | Annotation score: | ||
C9JCJ9 | C9JCJ9_HUMAN | Obg-like ATPase 1 | OLA1 | 103 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC013467 Genomic DNA No translation available. AC016737 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000409546; ENSP00000386350; ENSG00000138430 |
UCSCi | uc061ptz.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC013467 Genomic DNA No translation available. AC016737 Genomic DNA No translation available. |
3D structure databases
SMRi | J3KQ32 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | J3KQ32, 1 interactor |
Proteomic databases
EPDi | J3KQ32 |
MaxQBi | J3KQ32 |
PeptideAtlasi | J3KQ32 |
PRIDEi | J3KQ32 |
Protocols and materials databases
Antibodypediai | 19452, 276 antibodies |
Genome annotation databases
Ensembli | ENST00000409546; ENSP00000386350; ENSG00000138430 |
UCSCi | uc061ptz.1, human |
Organism-specific databases
HGNCi | HGNC:28833, OLA1 |
OpenTargetsi | ENSG00000138430 |
VEuPathDBi | HostDB:ENSG00000138430.15 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00390000000673 |
OMAi | VLRCFDN |
PhylomeDBi | J3KQ32 |
Miscellaneous databases
ChiTaRSi | OLA1, human |
Gene expression databases
Bgeei | ENSG00000138430, Expressed in cervix squamous epithelium and 246 other tissues |
ExpressionAtlasi | J3KQ32, baseline and differential |
Family and domain databases
CDDi | cd04867, TGS_YchF_OLA1, 1 hit cd01900, YchF, 1 hit |
Gene3Di | 1.10.150.300, 1 hit 3.10.20.30, 1 hit |
HAMAPi | MF_00944, YchF_OLA1_ATPase, 1 hit |
InterProi | View protein in InterPro IPR004396, ATPase_YchF/OLA1 IPR012675, Beta-grasp_dom_sf IPR031167, G_OBG IPR006073, GTP-bd IPR027417, P-loop_NTPase IPR004095, TGS IPR012676, TGS-like IPR023192, TGS-like_dom_sf IPR013029, YchF_C IPR041706, YchF_N |
Pfami | View protein in Pfam PF01926, MMR_HSR1, 1 hit PF06071, YchF-GTPase_C, 1 hit |
PIRSFi | PIRSF006641, CHP00092, 1 hit |
PRINTSi | PR00326, GTP1OBG |
SUPFAMi | SSF52540, SSF52540, 1 hit SSF81271, SSF81271, 1 hit |
TIGRFAMsi | TIGR00092, TIGR00092, 1 hit |
PROSITEi | View protein in PROSITE PS51710, G_OBG, 1 hit PS51880, TGS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | J3KQ32_HUMAN | |
Accessioni | J3KQ32Primary (citable) accession number: J3KQ32 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 3, 2012 |
Last sequence update: | October 3, 2012 | |
Last modified: | February 10, 2021 | |
This is version 68 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |