UniProtKB - J3KP33 (J3KP33_HUMAN)
Cellular tumor antigen p53
TP53
Functioni
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.
UniRule annotationCofactori
GO - Molecular functioni
- DNA-binding transcription factor activity Source: InterPro
- metal ion binding Source: UniProtKB-KW
- transcription cis-regulatory region binding Source: InterPro
GO - Biological processi
- apoptotic process Source: UniProtKB-KW
- cell cycle Source: UniProtKB-KW
- positive regulation of transcription, DNA-templated Source: UniProt
- rhythmic process Source: UniProtKB-KW
Keywordsi
Molecular function | ActivatorUniRule annotationARBA annotation, DNA-bindingUniRule annotation, RepressorARBA annotation |
Biological process | ApoptosisUniRule annotationARBA annotation, Biological rhythmsARBA annotation, Cell cycleUniRule annotationARBA annotation, NecrosisARBA annotation, Transcription, Transcription regulationUniRule annotation |
Ligand | Metal-bindingUniRule annotationARBA annotation, ZincUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Cellular tumor antigen p53UniRule annotationARBA annotation |
Gene namesi | Name:TP53Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11998, TP53 |
VEuPathDBi | HostDB:ENSG00000141510 |
Subcellular locationi
Nucleus
Mitochondrion
- Mitochondrion matrix ARBA annotation
Cytoplasm and Cytosol
- Cytoplasm UniRule annotation
Cytoskeleton
- centrosome ARBA annotation
Endoplasmic reticulum
- Endoplasmic reticulum ARBA annotation
Cytoskeleton
- microtubule organizing center Source: UniProtKB-SubCell
Cytosol
- cytosol Source: HPA
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB-SubCell
Mitochondrion
- mitochondrial matrix Source: UniProtKB-SubCell
Nucleus
- nucleoplasm Source: HPA
- PML body Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmUniRule annotation, Endoplasmic reticulumARBA annotation, NucleusUniRule annotationPTM / Processingi
Keywords - PTMi
Isopeptide bondARBA annotationProteomic databases
MaxQBi | J3KP33 |
PeptideAtlasi | J3KP33 |
PRIDEi | J3KP33 |
Expressioni
Gene expression databases
Bgeei | ENSG00000141510, Expressed in epithelium of mammary gland and 188 other tissues |
ExpressionAtlasi | J3KP33, baseline and differential |
Interactioni
Subunit structurei
Binds DNA as a homotetramer.
UniRule annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 6 – 29 | P53_TADInterPro annotationAdd BLAST | 24 | |
Domaini | 35 – 59 | TAD2InterPro annotationAdd BLAST | 25 | |
Domaini | 100 – 288 | P53InterPro annotationAdd BLAST | 189 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 50 – 96 | DisorderedSequence analysisAdd BLAST | 47 | |
Regioni | 282 – 343 | DisorderedSequence analysisAdd BLAST | 62 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 64 – 92 | Pro residuesSequence analysisAdd BLAST | 29 | |
Compositional biasi | 282 – 301 | Basic and acidic residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 305 – 319 | Polar residuesSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Phylogenomic databases
GeneTreei | ENSGT00950000183153 |
Family and domain databases
CDDi | cd08367, P53, 1 hit |
Gene3Di | 2.60.40.720, 1 hit |
InterProi | View protein in InterPro IPR008967, p53-like_TF_DNA-bd IPR012346, p53/RUNT-type_TF_DNA-bd_sf IPR011615, p53_DNA-bd IPR040926, p53_TAD2 IPR013872, p53_transactivation_domain IPR002117, p53_tumour_suppressor |
PANTHERi | PTHR11447, PTHR11447, 1 hit |
Pfami | View protein in Pfam PF00870, P53, 1 hit PF08563, P53_TAD, 1 hit PF18521, TAD2, 1 hit |
PRINTSi | PR00386, P53SUPPRESSR |
SUPFAMi | SSF49417, SSF49417, 1 hit |
PROSITEi | View protein in PROSITE PS00348, P53, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 12 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MEEPQSDPSV EPPLSQETFS DLWKLLPENN VLSPLPSQAM DDLMLSPDDI
60 70 80 90 100
EQWFTEDPGP DEAPRMPEAA PPVAPAPAAP TPAAPAPAPS WPLSSSVPSQ
110 120 130 140 150
KTYQGSYGFR LGFLHSGTAK SVTCTYSPAL NKMFCQLAKT CPVQLWVDST
160 170 180 190 200
PPPGTRVRAM AIYKQSQHMT EVVRRCPHHE RCSDSDGLAP PQHLIRVEGN
210 220 230 240 250
LRVEYLDDRN TFRHSVVVPY EPPEVGSDCT TIHYNYMCNS SCMGGMNRRP
260 270 280 290 300
ILTIITLEDS SGNLLGRNSF EVRVCACPGR DRRTEEENLR KKGEPHHELP
310 320 330 340
PGSTKRALPN NTSSSPQPKK KPLDGEYFTL QKTFPARHGG SHL
Computationally mapped potential isoform sequencesi
There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP04637 | P53_HUMAN | Cellular tumor antigen p53 | TP53 P53 | 393 | Annotation score: | ||
E7EQX7 | E7EQX7_HUMAN | Cellular tumor antigen p53 | TP53 | 285 | Annotation score: | ||
E7EMR6 | E7EMR6_HUMAN | Cellular tumor antigen p53 | TP53 | 165 | Annotation score: | ||
S4R334 | S4R334_HUMAN | Cellular tumor antigen p53 | TP53 | 143 | Annotation score: | ||
A0A0U1RQC9 | A0A0U1RQC9_HUMAN | Cellular tumor antigen p53 | TP53 | 410 | Annotation score: | ||
A0A087X1Q1 | A0A087X1Q1_HUMAN | Cellular tumor antigen p53 | TP53 | 234 | Annotation score: | ||
E9PFT5 | E9PFT5_HUMAN | Cellular tumor antigen p53 | TP53 | 155 | Annotation score: | ||
E9PCY9 | E9PCY9_HUMAN | Cellular tumor antigen p53 | TP53 | 127 | Annotation score: | ||
A0A087WT22 | A0A087WT22_HUMAN | Cellular tumor antigen p53 | TP53 | 187 | Annotation score: | ||
A0A087WXZ1 | A0A087WXZ1_HUMAN | Cellular tumor antigen p53 | TP53 | 182 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC007421 Genomic DNA No translation available. AC087388 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000359597; ENSP00000352610; ENSG00000141510 |
UCSCi | uc002gih.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC007421 Genomic DNA No translation available. AC087388 Genomic DNA No translation available. |
3D structure databases
SMRi | J3KP33 |
ModBasei | Search... |
Proteomic databases
MaxQBi | J3KP33 |
PeptideAtlasi | J3KP33 |
PRIDEi | J3KP33 |
Protocols and materials databases
Antibodypediai | 3525, 9276 antibodies from 63 providers |
Genome annotation databases
Ensembli | ENST00000359597; ENSP00000352610; ENSG00000141510 |
UCSCi | uc002gih.5, human |
Organism-specific databases
HGNCi | HGNC:11998, TP53 |
OpenTargetsi | ENSG00000141510 |
VEuPathDBi | HostDB:ENSG00000141510 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00950000183153 |
Miscellaneous databases
ChiTaRSi | TP53, human |
Gene expression databases
Bgeei | ENSG00000141510, Expressed in epithelium of mammary gland and 188 other tissues |
ExpressionAtlasi | J3KP33, baseline and differential |
Family and domain databases
CDDi | cd08367, P53, 1 hit |
Gene3Di | 2.60.40.720, 1 hit |
InterProi | View protein in InterPro IPR008967, p53-like_TF_DNA-bd IPR012346, p53/RUNT-type_TF_DNA-bd_sf IPR011615, p53_DNA-bd IPR040926, p53_TAD2 IPR013872, p53_transactivation_domain IPR002117, p53_tumour_suppressor |
PANTHERi | PTHR11447, PTHR11447, 1 hit |
Pfami | View protein in Pfam PF00870, P53, 1 hit PF08563, P53_TAD, 1 hit PF18521, TAD2, 1 hit |
PRINTSi | PR00386, P53SUPPRESSR |
SUPFAMi | SSF49417, SSF49417, 1 hit |
PROSITEi | View protein in PROSITE PS00348, P53, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | J3KP33_HUMAN | |
Accessioni | J3KP33Primary (citable) accession number: J3KP33 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 3, 2012 |
Last sequence update: | October 3, 2012 | |
Last modified: | January 19, 2022 | |
This is version 66 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |