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Protein
Submitted name:

Serine/arginine-rich-splicing factor 2

Gene

SRSF2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-bindingPROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Serine/arginine-rich-splicing factor 2Imported
Gene namesi
Name:SRSF2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000161547.14
HGNCiHGNC:10783 SRSF2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000161547

PTM / Processingi

Proteomic databases

EPDiJ3KP15
PeptideAtlasiJ3KP15
PRIDEiJ3KP15

Expressioni

Gene expression databases

BgeeiENSG00000161547 Expressed in 236 organ(s), highest expression level in female gonad
ExpressionAtlasiJ3KP15 baseline and differential

Interactioni

Protein-protein interaction databases

IntActiJ3KP15, 5 interactors

Structurei

3D structure databases

ProteinModelPortaliJ3KP15
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 92RRMInterPro annotationAdd BLAST79

Phylogenomic databases

eggNOGiKOG4207 Eukaryota
ENOG4111NJ8 LUCA
GeneTreeiENSGT00700000104403

Family and domain databases

Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR003954 RRM_dom_euk
IPR034893 SRSF2-like
PANTHERiPTHR23147:SF16 PTHR23147:SF16, 1 hit
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SM00361 RRM_1, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

J3KP15-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSYGRPPPDV EGMTSLKVDN LTYRTSPDTL RRVFEKYGRV GDVYIPRDRY
60 70 80 90 100
TKESRGFAFV RFHDKRDAED AMDAMDGAVL DGRELRVQMA RYGRPPDSHH
110 120 130
SRRGPPPRRY GGGGYGRRSR SRSRSRSRSR SRS
Length:133
Mass (Da):15,371
Last modified:October 5, 2016 - v8
Checksum:i6B5126D50339B26F
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q01130SRSF2_HUMAN
Serine/arginine-rich splicing facto...
SRSF2 SFRS2
221Annotation score:
J3QL05J3QL05_HUMAN
Serine/arginine-rich-splicing facto...
SRSF2
130Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei133Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005837 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000358156; ENSP00000350877; ENSG00000161547
UCSCiuc060knb.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005837 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliJ3KP15
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiJ3KP15, 5 interactors

Proteomic databases

EPDiJ3KP15
PeptideAtlasiJ3KP15
PRIDEiJ3KP15

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358156; ENSP00000350877; ENSG00000161547
UCSCiuc060knb.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000161547.14
HGNCiHGNC:10783 SRSF2
OpenTargetsiENSG00000161547
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4207 Eukaryota
ENOG4111NJ8 LUCA
GeneTreeiENSGT00700000104403

Miscellaneous databases

ChiTaRSiSRSF2 human

Gene expression databases

BgeeiENSG00000161547 Expressed in 236 organ(s), highest expression level in female gonad
ExpressionAtlasiJ3KP15 baseline and differential

Family and domain databases

Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR003954 RRM_dom_euk
IPR034893 SRSF2-like
PANTHERiPTHR23147:SF16 PTHR23147:SF16, 1 hit
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SM00361 RRM_1, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiJ3KP15_HUMAN
AccessioniPrimary (citable) accession number: J3KP15
Entry historyiIntegrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: October 5, 2016
Last modified: September 12, 2018
This is version 52 of the entry and version 8 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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