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Entry version 54 (26 Feb 2020)
Sequence version 1 (03 Oct 2012)
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Protein
Submitted name:

Collagen, type IV, alpha 4, isoform CRA_a

Gene

COL4A4

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Collagen, type IV, alpha 4, isoform CRA_aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:COL4A4Imported
ORF Names:hCG_19233Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Disulfide bondSAAS annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1462 – 1687Collagen IV NC1InterPro annotationAdd BLAST226

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni61 – 173DisorderedSequence analysisAdd BLAST113
Regioni187 – 258DisorderedSequence analysisAdd BLAST72
Regioni369 – 390DisorderedSequence analysisAdd BLAST22
Regioni405 – 451DisorderedSequence analysisAdd BLAST47
Regioni469 – 1454DisorderedSequence analysisAdd BLAST986

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi63 – 79Pro-richSequence analysisAdd BLAST17
Compositional biasi588 – 602PolyampholyteSequence analysisAdd BLAST15
Compositional biasi614 – 644Pro-richSequence analysisAdd BLAST31
Compositional biasi678 – 692Pro-richSequence analysisAdd BLAST15
Compositional biasi877 – 911Pro-richSequence analysisAdd BLAST35
Compositional biasi1115 – 1129Pro-richSequence analysisAdd BLAST15
Compositional biasi1218 – 1241Pro-richSequence analysisAdd BLAST24
Compositional biasi1253 – 1278Pro-richSequence analysisAdd BLAST26
Compositional biasi1295 – 1312Pro-richSequence analysisAdd BLAST18
Compositional biasi1332 – 1372Pro-richSequence analysisAdd BLAST41

Keywords - Domaini

CollagenSAAS annotationImported

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3544 Eukaryota
ENOG410YAVF LUCA

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.170.240.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008160 Collagen
IPR001442 Collagen_IV_NC
IPR036954 Collagen_IV_NC_sf
IPR016187 CTDL_fold

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01413 C4, 2 hits
PF01391 Collagen, 15 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00111 C4, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56436 SSF56436, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51403 NC1_IV, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

J3KNM7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWSLHIVLMR CSFRLTKSLA TGPWSLILIL FSVQYVYGSG KKYIGPCGGR
60 70 80 90 100
DCSVCHCVPE KGSRGPPGPP GPQGPIGPLG APGPIGLSGE KGMRGDRGPP
110 120 130 140 150
GAAGDKGDKG PTGVPGFPGL DGIPGHPGPP GPRGKPGMSG HNGSRGDPGF
160 170 180 190 200
PGGRGALGPG GPLGHPGEKG EKGNSVFILG AVKGIQGDRG DPGLPGLPGS
210 220 230 240 250
WGAGGPAGPT GYPGEPGLVG PPGQPGRPGL KGNPGVGVKG QMGDPGEVGQ
260 270 280 290 300
QGSPGPTLLV EPPDFCLYKG EKGIKGIPGM VGLPGPPGRK GESGIGAKGE
310 320 330 340 350
KGIPGFPGPR GDPGSYGSPG FPGLKGELGL VGDPGLFGLI GPKGDPGNRG
360 370 380 390 400
HPGPPGVLVT PPLPLKGPPG DPGFPGRYGE TGDVGPPGPP GLLGRPGEAC
410 420 430 440 450
AGMIGPPGPQ GFPGLPGLPG EAGIPGRPDS APGKPGKPGS PGLPGAPGLQ
460 470 480 490 500
GLPGSSVIYC SVGNPGPQGI KGKVGPPGGR GPKGEKGNEG LCACEPGPMG
510 520 530 540 550
PPGPPGLPGR QGSKGDLGLP GWLGTKGDPG PPGAEGPPGL PGKHGASGPP
560 570 580 590 600
GNKGAKGDMV VSRVKGHKGE RGPDGPPGFP GQPGSHGRDG HAGEKGDPGP
610 620 630 640 650
PGDHEDATPG GKGFPGPLGP PGKAGPVGPP GLGFPGPPGE RGHPGVPGHP
660 670 680 690 700
GVRGPDGLKG QKGDTISCNV TYPGRHGPPG FDGPPGPKGF PGPQGAPGLS
710 720 730 740 750
GSDGHKGRPG TPGTAEIPGP PGFRGDMGDP GFGGEKGSSP VGPPGPPGSP
760 770 780 790 800
GVNGQKGIPG DPAFGHLGPP GKRGLSGVPG IKGPRGDPGC PGAEGPAGIP
810 820 830 840 850
GFLGLKGPKG REGHAGFPGV PGPPGHSCER GAPGIPGQPG LPGYPGSPGA
860 870 880 890 900
PGGKGQPGDV GPPGPAGMKG LPGLPGRPGA HGPPGLPGIP GPFGDDGLPG
910 920 930 940 950
PPGPKGPRGL PGFPGFPGER GKPGAEGCPG AKGEPGEKGM SGLPGDRGLR
960 970 980 990 1000
GAKGAIGPPG DEGEMAIISQ KGTPGEPGPP GDDGFPGERG DKGTPGMQGR
1010 1020 1030 1040 1050
RGEPGRYGPP GFHRGEPGEK GQPGPPGPPG PPGSTGLRGF IGFPGLPGDQ
1060 1070 1080 1090 1100
GEPGSPGPPG FSGIDGARGP KGNKGDPASH FGPPGPKGEP GSPGCPGHFG
1110 1120 1130 1140 1150
ASGEQGLPGI QGPRGSPGRP GPPGSSGPPG CPGDHGMPGL RGQPGEMGDP
1160 1170 1180 1190 1200
GPRGLQGDPG IPGPPGIKGP SGSPGLNGLH GLKGQKGTKG ASGLHDVGPP
1210 1220 1230 1240 1250
GPVGIPGLKG ERGDPGSPGI SPPGPRGKKG PPGPPGSSGP PGPAGATGRA
1260 1270 1280 1290 1300
PKDIPDPGPP GDQGPPGPDG PRGAPGPPGL PGSVDLLRGE PGDCGLPGPP
1310 1320 1330 1340 1350
GPPGPPGPPG YKGFPGCDGK DGQKGPVGFP GPQGPHGFPG PPGEKGLPGP
1360 1370 1380 1390 1400
PGRKGPTGLP GEPGPPADVD DCPRIPGLPG APGMRGPEGA MGLPGMRGPS
1410 1420 1430 1440 1450
GPGCKGEPGL DGRRGVDGVP GSPGPPGRKG DTGEDGYPGG PGPPGPIGDP
1460 1470 1480 1490 1500
GPKGFGPGYL GGFLLVLHSQ TDQEPTCPLG MPRLWTGYSL LYLEGQEKAH
1510 1520 1530 1540 1550
NQDLGLAGSC LPVFSTLPFA YCNIHQVCHY AQRNDRSYWL ASAAPLPMMP
1560 1570 1580 1590 1600
LSEEAIRPYV SRCAVCEAPA QAVAVHSQDQ SIPPCPQTWR SLWIGYSFLM
1610 1620 1630 1640 1650
HTGAGDQGGG QALMSPGSCL EDFRAAPFLE CQGRQGTCHF FANKYSFWLT
1660 1670 1680
TVKADLQFSS APAPDTLKES QAQRQKISRC QVCVKYS
Length:1,687
Mass (Da):163,727
Last modified:October 3, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4EC47FAEED2B150A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CH471063 Genomic DNA Translation: EAW70845.1
CH471063 Genomic DNA Translation: EAW70846.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471063 Genomic DNA Translation: EAW70845.1
CH471063 Genomic DNA Translation: EAW70846.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Phylogenomic databases

eggNOGiKOG3544 Eukaryota
ENOG410YAVF LUCA

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
COL4A4 human

Family and domain databases

Gene3Di2.170.240.10, 1 hit
InterProiView protein in InterPro
IPR008160 Collagen
IPR001442 Collagen_IV_NC
IPR036954 Collagen_IV_NC_sf
IPR016187 CTDL_fold
PfamiView protein in Pfam
PF01413 C4, 2 hits
PF01391 Collagen, 15 hits
SMARTiView protein in SMART
SM00111 C4, 2 hits
SUPFAMiSSF56436 SSF56436, 2 hits
PROSITEiView protein in PROSITE
PS51403 NC1_IV, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiJ3KNM7_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: J3KNM7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: October 3, 2012
Last modified: February 26, 2020
This is version 54 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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