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UniProtKB - J3KN83 (J3KN83_HUMAN)
Protein
Submitted name:
CD44 antigen
Gene
CD44
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- hyaluronic acid binding Source: InterPro
GO - Biological processi
- cell adhesion Source: InterPro
Names & Taxonomyi
Protein namesi | Submitted name: CD44 antigenImported |
Gene namesi | Name:CD44Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1681, CD44 |
VEuPathDBi | HostDB:ENSG00000026508 |
Subcellular locationi
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 169 – 190 | HelicalSequence analysisAdd BLAST | 22 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSG00000026508, Expressed in parotid gland and 242 other tissues |
ExpressionAtlasi | J3KN83, baseline and differential |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 161 | DisorderedSequence analysisAdd BLAST | 161 | |
Regioni | 212 – 232 | DisorderedSequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 9 – 32 | Polar residuesSequence analysisAdd BLAST | 24 | |
Compositional biasi | 51 – 78 | Polar residuesSequence analysisAdd BLAST | 28 | |
Compositional biasi | 86 – 103 | Polar residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 118 – 139 | Polar residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 146 – 161 | Polar residuesSequence analysisAdd BLAST | 16 |
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
GeneTreei | ENSGT00530000063822 |
Family and domain databases
InterProi | View protein in InterPro IPR001231, CD44_antigen IPR043210, CD44_antigen-like |
PANTHERi | PTHR10225, PTHR10225, 1 hit PTHR10225:SF6, PTHR10225:SF6, 1 hit |
PRINTSi | PR00658, CD44 |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 20 potential isoforms that are computationally mapped.Show allAlign All
J3KN83-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
PEDIYPSNPT DDDVSSGSSS ERSSTSGGYI FYTFSTVHPI PDEDSPWITD
60 70 80 90 100
STDRIPATNM DSSHSITLQP TANPNTGLVE DLDRTGPLSM TTQQSNSQSF
110 120 130 140 150
STSHEGLEED KDHPTTSTLT SSRDQDTFHP SGGSHTTHGS ESDGHSHGSQ
160 170 180 190 200
EGGANTTSGP IRTPQIPEWL IILASLLALA LILAVCIAVN SRRRCGQKKK
210 220 230
LVINSGNGAV EDRKPSGLNG EASKSQEMVH LV
Computationally mapped potential isoform sequencesi
There are 20 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP16070 | CD44_HUMAN | CD44 antigen | CD44 LHR, MDU2, MDU3, MIC4 | 742 | Annotation score: | ||
H0Y5E4 | H0Y5E4_HUMAN | CD44 antigen | CD44 | 294 | Annotation score: | ||
H0YCV9 | H0YCV9_HUMAN | CD44 antigen | CD44 | 277 | Annotation score: | ||
H0Y2P0 | H0Y2P0_HUMAN | CD44 antigen | CD44 | 287 | Annotation score: | ||
H0YD13 | H0YD13_HUMAN | CD44 antigen | CD44 | 206 | Annotation score: | ||
H0YD17 | H0YD17_HUMAN | CD44 antigen | CD44 | 229 | Annotation score: | ||
H0YDX6 | H0YDX6_HUMAN | CD44 antigen | CD44 | 183 | Annotation score: | ||
H0YDW7 | H0YDW7_HUMAN | CD44 antigen | CD44 | 240 | Annotation score: | ||
E9PKC6 | E9PKC6_HUMAN | CD44 antigen | CD44 | 78 | Annotation score: | ||
Q86UZ1 | Q86UZ1_HUMAN | CD44 antigen | CD44 | 80 | Annotation score: | ||
There are more potential isoformsShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 | |
Non-terminal residuei | 232 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL133330 Genomic DNA No translation available. AL136989 Genomic DNA No translation available. AL356215 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000278385; ENSP00000278385; ENSG00000026508 |
UCSCi | uc058ajb.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL133330 Genomic DNA No translation available. AL136989 Genomic DNA No translation available. AL356215 Genomic DNA No translation available. |
3D structure databases
SMRi | J3KN83 |
ModBasei | Search... |
Proteomic databases
MaxQBi | J3KN83 |
PeptideAtlasi | J3KN83 |
PRIDEi | J3KN83 |
Protocols and materials databases
Antibodypediai | 804, 5420 antibodies from 58 providers |
Genome annotation databases
Ensembli | ENST00000278385; ENSP00000278385; ENSG00000026508 |
UCSCi | uc058ajb.1, human |
Organism-specific databases
HGNCi | HGNC:1681, CD44 |
OpenTargetsi | ENSG00000026508 |
VEuPathDBi | HostDB:ENSG00000026508 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00530000063822 |
Miscellaneous databases
ChiTaRSi | CD44, human |
Gene expression databases
Bgeei | ENSG00000026508, Expressed in parotid gland and 242 other tissues |
ExpressionAtlasi | J3KN83, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR001231, CD44_antigen IPR043210, CD44_antigen-like |
PANTHERi | PTHR10225, PTHR10225, 1 hit PTHR10225:SF6, PTHR10225:SF6, 1 hit |
PRINTSi | PR00658, CD44 |
MobiDBi | Search... |
Entry informationi
Entry namei | J3KN83_HUMAN | |
Accessioni | J3KN83Primary (citable) accession number: J3KN83 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 3, 2012 |
Last sequence update: | October 3, 2012 | |
Last modified: | January 19, 2022 | |
This is version 61 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |