UniProtKB - J3KN39 (J3KN39_HUMAN)
Protein
Submitted name:
NACHT, LRR and PYD domains-containing protein 2
Gene
NLRP2
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Submitted name: NACHT, LRR and PYD domains-containing protein 2Imported |
Gene namesi | Name:NLRP2Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:22948, NLRP2 |
VEuPathDBi | HostDB:ENSG00000022556.15 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Golgi apparatus
- Golgi apparatus Source: HPA
Other locations
- intracellular membrane-bounded organelle Source: HPA
Expressioni
Gene expression databases
Bgeei | ENSG00000022556, Expressed in secondary oocyte and 167 other tissues |
ExpressionAtlasi | J3KN39, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 94 | PyrinInterPro annotationAdd BLAST | 94 | |
Domaini | 204 – 402 | NACHTInterPro annotationAdd BLAST | 199 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 1010 – 1041 | Sequence analysisAdd BLAST | 32 |
Sequence similaritiesi
Belongs to the NLRP family.ARBA annotation
Keywords - Domaini
Coiled coilSequence analysis, Leucine-rich repeatARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000161714 |
Family and domain databases
Gene3Di | 3.80.10.10, 2 hits |
InterProi | View protein in InterPro IPR004020, DAPIN IPR011029, DEATH-like_dom_sf IPR001611, Leu-rich_rpt IPR032675, LRR_dom_sf IPR007111, NACHT_NTPase IPR041267, NLRP_HD2 IPR041075, NOD2_WH IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF13516, LRR_6, 4 hits PF05729, NACHT, 1 hit PF17776, NLRC4_HD2, 1 hit PF17779, NOD2_WH, 1 hit PF02758, PYRIN, 1 hit |
SMARTi | View protein in SMART SM01289, PYRIN, 1 hit |
SUPFAMi | SSF47986, SSF47986, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50824, DAPIN, 1 hit PS50837, NACHT, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 17 potential isoforms that are computationally mapped.Show allAlign All
J3KN39-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVSSAQMGFN LQALLEQLSQ DELSKFKYLI TTFSLAHELQ KIPHKEVDKA
60 70 80 90 100
DGKQLVEILT THCDSYWVEM ASLQVFEKMH RMDLSERAKD EVREAALKSF
110 120 130 140 150
NKRKPLSLGI TRKERPPLDV DEMLERFKTE AQETKGNVIC LGKEVFKGKK
160 170 180 190 200
PDKDNRCRYI LKTKFREMWK SWPGDSKEVQ VMAERYKMLI PFSNPRVLPG
210 220 230 240 250
PFSYTVVLYG PAGLGKTTLA QKLMLDWAED NLIHKFKYAF YLSCRELSRL
260 270 280 290 300
GPCSFAELVF RDWPELQDDI PHILAQARKI LFVIDGFDEL GAAPGALIED
310 320 330 340 350
ICGDWEKKKP VPVLLGSLLN RVMLPKAALL VTTRPRALRD LRILAEEPIY
360 370 380 390 400
IRVEGFLEED RRAYFLRHFG DEDQAMRAFE LMRSNAALFQ LGSAPAVCWI
410 420 430 440 450
VCTTLKLQME KGEDPVPTCL TRTGLFLRFL CSRFPQGAQL RGALRTLSLL
460 470 480 490 500
AAQGLWAQTS VLHREDLERL GVQESDLRLF LDGDILRQDR VSKGCYSFIH
510 520 530 540 550
LSFQQFLTAL FYTLEKEEEE DRDGHTWDIG DVQKLLSGVE RLRNPDLIQA
560 570 580 590 600
GYYSFGLANE KRAKELEATF GCRMSPDIKQ ELLRCDISCK GGHSTVTDLQ
610 620 630 640 650
ELLGCLYESQ EEELVKEVMA QFKEISLHLN AVDVVPSSFC VKHCRNLQKM
660 670 680 690 700
SLQVIKENLP ENVTASESDA EVERSQDDQH MLPFWTDLCS IFGSNKDLMG
710 720 730 740 750
LAINDSFLSA SLVRILCEQI ASDTCHLQRV VFKNISPADA HRNLCLALRG
760 770 780 790 800
HKTVTYLTLQ GNDQDDMFPA LCEVLRHPEC NLRYLGLVSC SATTQQWADL
810 820 830 840 850
SLALEVNQSL TCVNLSDNEL LDEGAKLLYT TLRHPKCFLQ RLSLENCHLT
860 870 880 890 900
EANCKDLAAV LVVSRELTHL CLAKNPIGNT GVKFLCEGLR YPECKLQTLV
910 920 930 940 950
LWNCDITSDG CCDLTKLLQE KSSLLCLDLG LNHIGVKGMK FLCEALRKPL
960 970 980 990 1000
CNLRCLWLWG CSIPPFSCED LCSALSCNQS LVTLDLGQNP LGSSGVKMLF
1010 1020 1030 1040 1050
ETLTCSSGTL RTLRLKIDDF NDELNKLLEE IEEKNPQLII DTEKHHPWAE
RPSSHDFMI
Computationally mapped potential isoform sequencesi
There are 17 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9NX02 | NALP2_HUMAN | NACHT, LRR and PYD domains-containi... | NLRP2 NALP2, NBS1, PAN1, PYPAF2 | 1,062 | Annotation score: | ||
K7EMK2 | K7EMK2_HUMAN | NACHT, LRR and PYD domains-containi... | NLRP2 | 197 | Annotation score: | ||
A0A0G2JLX3 | A0A0G2JLX3_HUMAN | NACHT, LRR and PYD domains-containi... | NLRP2 | 1,040 | Annotation score: | ||
A0A0G2JMG8 | A0A0G2JMG8_HUMAN | NACHT, LRR and PYD domains-containi... | NLRP2 | 1,039 | Annotation score: | ||
A0A0G2JPQ2 | A0A0G2JPQ2_HUMAN | NACHT, LRR and PYD domains-containi... | NLRP2 | 1,062 | Annotation score: | ||
F5H5B1 | F5H5B1_HUMAN | NACHT, LRR and PYD domains-containi... | NLRP2 | 154 | Annotation score: | ||
F5GYZ4 | F5GYZ4_HUMAN | NACHT, LRR and PYD domains-containi... | NLRP2 | 165 | Annotation score: | ||
F5H7Q5 | F5H7Q5_HUMAN | NACHT, LRR and PYD domains-containi... | NLRP2 | 109 | Annotation score: | ||
K7EJ90 | K7EJ90_HUMAN | NACHT, LRR and PYD domains-containi... | NLRP2 | 124 | Annotation score: | ||
K7ELX1 | K7ELX1_HUMAN | NACHT, LRR and PYD domains-containi... | NLRP2 | 140 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC011476 Genomic DNA No translation available. |
RefSeqi | NP_001334932.1, NM_001348003.1 |
Genome annotation databases
Ensembli | ENST00000263437; ENSP00000263437; ENSG00000022556 ENST00000612740; ENSP00000479677; ENSG00000273992 |
GeneIDi | 55655 |
UCSCi | uc010eso.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC011476 Genomic DNA No translation available. |
RefSeqi | NP_001334932.1, NM_001348003.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PRIDEi | J3KN39 |
Protocols and materials databases
Antibodypediai | 19479, 301 antibodies |
Genome annotation databases
Ensembli | ENST00000263437; ENSP00000263437; ENSG00000022556 ENST00000612740; ENSP00000479677; ENSG00000273992 |
GeneIDi | 55655 |
UCSCi | uc010eso.4, human |
Organism-specific databases
CTDi | 55655 |
HGNCi | HGNC:22948, NLRP2 |
OpenTargetsi | ENSG00000022556 |
VEuPathDBi | HostDB:ENSG00000022556.15 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000161714 |
Miscellaneous databases
BioGRID-ORCSi | 55655, 8 hits in 871 CRISPR screens |
ChiTaRSi | NLRP2, human |
GenomeRNAii | 55655 |
Gene expression databases
Bgeei | ENSG00000022556, Expressed in secondary oocyte and 167 other tissues |
ExpressionAtlasi | J3KN39, baseline and differential |
Family and domain databases
Gene3Di | 3.80.10.10, 2 hits |
InterProi | View protein in InterPro IPR004020, DAPIN IPR011029, DEATH-like_dom_sf IPR001611, Leu-rich_rpt IPR032675, LRR_dom_sf IPR007111, NACHT_NTPase IPR041267, NLRP_HD2 IPR041075, NOD2_WH IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF13516, LRR_6, 4 hits PF05729, NACHT, 1 hit PF17776, NLRC4_HD2, 1 hit PF17779, NOD2_WH, 1 hit PF02758, PYRIN, 1 hit |
SMARTi | View protein in SMART SM01289, PYRIN, 1 hit |
SUPFAMi | SSF47986, SSF47986, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50824, DAPIN, 1 hit PS50837, NACHT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | J3KN39_HUMAN | |
Accessioni | J3KN39Primary (citable) accession number: J3KN39 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 3, 2012 |
Last sequence update: | October 3, 2012 | |
Last modified: | February 10, 2021 | |
This is version 78 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |