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Entry version 71 (02 Dec 2020)
Sequence version 1 (03 Oct 2012)
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Protein
Submitted name:

Afadin

Gene

AFDN

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesionARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
AfadinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AFDNImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...
EuPathDBi
HostDB:ENSG00000130396.20

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7137, AFDN

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000130396

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
J3KN01

PeptideAtlas

More...
PeptideAtlasi
J3KN01

PRoteomics IDEntifications database

More...
PRIDEi
J3KN01

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000130396, Expressed in oviduct epithelium and 216 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
J3KN01, baseline and differential

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini39 – 133Ras-associatingInterPro annotationAdd BLAST95
Domaini246 – 348Ras-associatingInterPro annotationAdd BLAST103
Domaini668 – 915DiluteInterPro annotationAdd BLAST248
Domaini1014 – 1100PDZInterPro annotationAdd BLAST87

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni128 – 194DisorderedSequence analysisAdd BLAST67
Regioni349 – 378DisorderedSequence analysisAdd BLAST30
Regioni539 – 595DisorderedSequence analysisAdd BLAST57
Regioni1114 – 1230DisorderedSequence analysisAdd BLAST117
Regioni1242 – 1480DisorderedSequence analysisAdd BLAST239
Regioni1508 – 1535DisorderedSequence analysisAdd BLAST28
Regioni1576 – 1831DisorderedSequence analysisAdd BLAST256

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi143 – 194PolyampholyteSequence analysisAdd BLAST52
Compositional biasi349 – 369PolyampholyteSequence analysisAdd BLAST21
Compositional biasi544 – 568PolarSequence analysisAdd BLAST25
Compositional biasi1136 – 1152PolarSequence analysisAdd BLAST17
Compositional biasi1161 – 1176PolyampholyteSequence analysisAdd BLAST16
Compositional biasi1178 – 1216PolarSequence analysisAdd BLAST39
Compositional biasi1281 – 1307PolyampholyteSequence analysisAdd BLAST27
Compositional biasi1309 – 1347PolarSequence analysisAdd BLAST39
Compositional biasi1367 – 1382Pro-richSequence analysisAdd BLAST16
Compositional biasi1413 – 1449PolyampholyteSequence analysisAdd BLAST37
Compositional biasi1450 – 1480PolarSequence analysisAdd BLAST31
Compositional biasi1521 – 1535PolyampholyteSequence analysisAdd BLAST15
Compositional biasi1597 – 1683PolyampholyteSequence analysisAdd BLAST87
Compositional biasi1689 – 1718Pro-richSequence analysisAdd BLAST30
Compositional biasi1769 – 1783PolyampholyteSequence analysisAdd BLAST15
Compositional biasi1784 – 1815PolarSequence analysisAdd BLAST32
Compositional biasi1816 – 1831PolyampholyteSequence analysisAdd BLAST16

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155237

Database of Orthologous Groups

More...
OrthoDBi
23029at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00060, FHA, 1 hit
cd15471, Myo5p-like_CBD_afadin, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.42.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037977, CBD_Afadin
IPR002710, Dilute_dom
IPR000253, FHA_dom
IPR001478, PDZ
IPR036034, PDZ_sf
IPR000159, RA_dom
IPR008984, SMAD_FHA_dom_sf
IPR029071, Ubiquitin-like_domsf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01843, DIL, 1 hit
PF00498, FHA, 1 hit
PF00595, PDZ, 1 hit
PF00788, RA, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01132, DIL, 1 hit
SM00240, FHA, 1 hit
SM00228, PDZ, 1 hit
SM00314, RA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49879, SSF49879, 1 hit
SSF50156, SSF50156, 1 hit
SSF54236, SSF54236, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51126, DILUTE, 1 hit
PS50106, PDZ, 1 hit
PS50200, RA, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 11 potential isoforms that are computationally mapped.Show allAlign All

J3KN01-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAGGRDEER RKLADIIHHW NANRLDLFEI SQPTEDLEFH GVMRFYFQDK
60 70 80 90 100
AAGNFATKCI RVSSTATTQD VIETLAEKFR PDMRMLSSPK YSLYEVHVSG
110 120 130 140 150
ERRLDIDEKP LVVQLNWNKD DREGRFVLKN ENDAIPPKKA QSNGPEKQEK
160 170 180 190 200
EGVIQNFKRT LSKKEKKEKK KREKEALRQA SDKDDRPFQG EDVENSRLAA
210 220 230 240 250
EVYKDMPETS FTRTISNPEV VMKRRRQQKL EKRMQEFRSS DGRPDSGGTL
260 270 280 290 300
RIYADSLKPN IPYKTILLST TDPADFAVAE ALEKYGLEKE NPKDYCIARV
310 320 330 340 350
MLPPGAQHSD EKGAKEIILD DDECPLQIFR EWPSDKGILV FQLKRRPPDH
360 370 380 390 400
IPKKTKKHLE GKTPKGKERA DGSGYGSTLP PEKLPYLVEL SPGRRNHFAY
410 420 430 440 450
YNYHTYEDGS DSRDKPKLYR LQLSVTEVGT EKLDDNSIQL FGPGIQPHHC
460 470 480 490 500
DLTNMDGVVT VTPRSMDAET YVEGQRISET TMLQSGMKVQ FGASHVFKFV
510 520 530 540 550
DPSQDHALAK RSVDGGLMVK GPRHKPGIVQ ETTFDLGGDI HSGTALPTSK
560 570 580 590 600
STTRLDSDRV SSASSTAERG MVKPMIRVEQ QPDYRRQESR TQDASGPELI
610 620 630 640 650
LPASIEFRES SEDSFLSAII NYTNSSTVHF KLSPTYVLYM ACRYVLSNQY
660 670 680 690 700
RPDISPTERT HKVIAVVNKM VSMMEGVIQE VDQVDQKQKN IAGALAFWMA
710 720 730 740 750
NASELLNFIK QDRDLSRITL DAQDVLAHLV QMAFKYLVHC LQSELNNYMP
760 770 780 790 800
AFLDDPEENS LQRPKIDDVL HTLTGAMSLL RRCRVNAALT IQLFSQLFHF
810 820 830 840 850
INMWLFNRLV TDPDSGLCSH YWGAIIRQQL GHIEAWAEKQ GLELAADCHL
860 870 880 890 900
SRIVQATTLL TMDKYAPDDI PNINSTCFKL NSLQLQALLQ NYHCAPDEPF
910 920 930 940 950
IPTDLIENVV TVAENTADEL ARSDGREVQL EEDPDLQLPF LLPEDGYSCD
960 970 980 990 1000
VVRNIPNGLQ EFLDPLCQRG FCRLIPHTRS PGTWTIYFEG ADYESHLLRE
1010 1020 1030 1040 1050
NTELAQPLRK EPEIITVTLK KQNGMGLSIV AAKGAGQDKL GIYVKSVVKG
1060 1070 1080 1090 1100
GAADVDGRLA AGDQLLSVDG RSLVGLSQER AAELMTRTSS VVTLEVAKQG
1110 1120 1130 1140 1150
AIYHGLATLL NQPSPMMQRI SDRRGSGKPR PKSEGFELYN NSTQNGSPES
1160 1170 1180 1190 1200
PQLPWAEYSE PKKLPGDDRL MKNRADHRSS PNVANQPPSP GGKSAYASGT
1210 1220 1230 1240 1250
TAKITSVSTG NLCTEEQTPP PRPEAYPIPT QTYTREYFTF PASKSQDRMA
1260 1270 1280 1290 1300
PPQNQWPNYE EKPHMHTDSN HSSIAIQRVT RSQEELREDK AYQLERHRIE
1310 1320 1330 1340 1350
AAMDRKSDSD MWINQSSSLD SSTSSQEHLN HSSKSVTPAS TLTKSGPGRW
1360 1370 1380 1390 1400
KTPAAIPATP VAVSQPIRTD LPPPPPPPPV HYAGDFDGMS MDLPLPPPPS
1410 1420 1430 1440 1450
ANQIGLPSAQ VAAAERRKRE EHQRWYEKEK ARLEEERERK RREQERKLGQ
1460 1470 1480 1490 1500
MRTQSLNPAP FSPLTAQQMK PEKPSTLQRP QETVIRELQP QQQPRTIERR
1510 1520 1530 1540 1550
DLQYITVSKE ELSSGDSLSP DPWKRDAKEK LEKQQQMHIV DMLSKEIQEL
1560 1570 1580 1590 1600
QSKPDRSAEE SDRLRKLMLE WQFQKRLQES KQKDEDDEEE EDDDVDTMLI
1610 1620 1630 1640 1650
MQRLEAERRA RLQDEERRRQ QQLEEMRKRE AEDRARQEEE RRRQEEERTK
1660 1670 1680 1690 1700
RDAEEKRRQE EGYYSRLEAE RRRQHDEAAR RLLEPEAPGL CRPPLPRDYE
1710 1720 1730 1740 1750
PPSPSPAPGA PPPPPQRNAS YLKTQVLSPD SLFTAKFVAY NEEEEEEDCS
1760 1770 1780 1790 1800
LAGPNSYPGS TGAAVGAHDA CRDAKEKRSK SQDADSPGSS GAPENLTFKE
1810 1820 1830
RQRLFSQGQD VSNKVKASRK LTELENELNT K
Length:1,831
Mass (Da):207,618
Last modified:October 3, 2012 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5B92CEAED3037CFE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P55196AFAD_HUMAN
Afadin
AFDN AF6, MLLT4
1,824Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A8MQ02A8MQ02_HUMAN
Afadin
AFDN
1,781Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5TIG5Q5TIG5_HUMAN
Afadin
AFDN
1,665Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y7R8H0Y7R8_HUMAN
Afadin
AFDN
389Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PFY5E9PFY5_HUMAN
Afadin
AFDN
250Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W9I4F8W9I4_HUMAN
Afadin
AFDN
247Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YA98H0YA98_HUMAN
Afadin
AFDN
167Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y8L4H0Y8L4_HUMAN
Afadin
AFDN
313Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y8U8H0Y8U8_HUMAN
Afadin
AFDN
124Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y948H0Y948_HUMAN
Afadin
AFDN
191Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There is more potential isoformShow all

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL009178 Genomic DNA No translation available.
AL049698 Genomic DNA No translation available.
AL731868 Genomic DNA No translation available.
KF458344 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_016866368.1, XM_017010879.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000351017; ENSP00000252692; ENSG00000130396

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4301

UCSC genome browser

More...
UCSCi
uc063sxo.1, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL009178 Genomic DNA No translation available.
AL049698 Genomic DNA No translation available.
AL731868 Genomic DNA No translation available.
KF458344 Genomic DNA No translation available.
RefSeqiXP_016866368.1, XM_017010879.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

MaxQBiJ3KN01
PeptideAtlasiJ3KN01
PRIDEiJ3KN01

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
4608, 260 antibodies

Genome annotation databases

EnsembliENST00000351017; ENSP00000252692; ENSG00000130396
GeneIDi4301
UCSCiuc063sxo.1, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4301
EuPathDBiHostDB:ENSG00000130396.20
HGNCiHGNC:7137, AFDN
OpenTargetsiENSG00000130396

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00940000155237
OrthoDBi23029at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
4301, 22 hits in 851 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
AFDN, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
4301

Gene expression databases

BgeeiENSG00000130396, Expressed in oviduct epithelium and 216 other tissues
ExpressionAtlasiJ3KN01, baseline and differential

Family and domain databases

CDDicd00060, FHA, 1 hit
cd15471, Myo5p-like_CBD_afadin, 1 hit
Gene3Di2.30.42.10, 1 hit
InterProiView protein in InterPro
IPR037977, CBD_Afadin
IPR002710, Dilute_dom
IPR000253, FHA_dom
IPR001478, PDZ
IPR036034, PDZ_sf
IPR000159, RA_dom
IPR008984, SMAD_FHA_dom_sf
IPR029071, Ubiquitin-like_domsf
PfamiView protein in Pfam
PF01843, DIL, 1 hit
PF00498, FHA, 1 hit
PF00595, PDZ, 1 hit
PF00788, RA, 2 hits
SMARTiView protein in SMART
SM01132, DIL, 1 hit
SM00240, FHA, 1 hit
SM00228, PDZ, 1 hit
SM00314, RA, 2 hits
SUPFAMiSSF49879, SSF49879, 1 hit
SSF50156, SSF50156, 1 hit
SSF54236, SSF54236, 2 hits
PROSITEiView protein in PROSITE
PS51126, DILUTE, 1 hit
PS50106, PDZ, 1 hit
PS50200, RA, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiJ3KN01_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: J3KN01
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 3, 2012
Last sequence update: October 3, 2012
Last modified: December 2, 2020
This is version 71 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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